Results 71 to 80 of about 699,964 (265)
Molecular Oncology, EarlyView.Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant +11 more
wiley +1 more source
Bone & Joint ResearchAims: Nonunion is a challenging condition marked by impaired bone healing and vascularization. While magnesium-based biomaterials show osteogenic and angiogenic potential, their role in nonunion remains controversial. Controlled modification of magnesium-
Alina Marie Schmitz +9 more
doaj +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Bone & Joint ResearchAims: Recombinant human bone morphogenetic protein-2 (rhBMP-2) is used clinically for bone regeneration. The Food and Drug Administration-approved clinical product (Infuse) is Chinese hamster ovary (CHO)-derived, but Escherichia coli (EC)-derived rhBMP-2
Charles Matthews +3 more
doaj +1 more source
Molecular Oncology, EarlyView.The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant +7 more
wiley +1 more source
Research progress on the role of NLRP3 inflammasome in bone homeostasis regulation
Shiyong laonian yixueNucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome is a crucial effector complex of the innate immune system and has recently been recognized as playing a key role in regulating bone homeostasis.
LIU Yanling, ZHOU Ping
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Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs
FEBS Open Bio, EarlyView.Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner +7 more
wiley +1 more source
Long-term Consequences of Traumatic Brain Injury in Bone Metabolism
Frontiers in Neurology, 2018 Traumatic brain injury (TBI) leads to long-term cognitive, behavioral, affective deficits, and increase neurodegenerative diseases. It is only in recent years that there is growing awareness that TBI even in its milder form poses long-term health ...
Nikita M. Bajwa +5 more
doaj +1 more source
FEBS Open Bio, EarlyView.Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin +3 more
wiley +1 more source
Statin: A boon in periodontal therapy
SRM Journal of Research in Dental Sciences, 2015 Periodontitis is an inflammatory process causing gradual destruction of the periodontal tissues and alveolar bone loss. Various periodontal therapies have been introduced to lower the destruction, statin being one among them.
Sahana Purushotham +2 more
doaj +1 more source