Results 71 to 80 of about 727,396 (265)
Bone & Joint ResearchAims: Nonunion is a challenging condition marked by impaired bone healing and vascularization. While magnesium-based biomaterials show osteogenic and angiogenic potential, their role in nonunion remains controversial. Controlled modification of magnesium-
Alina Marie Schmitz +9 more
doaj +1 more source
Osteoblasts and bone formation.
Acta reumatologica portuguesa, 2007 © 2007 Sociedade Portuguesa de ...
Caetano-Lopes, Joana +2 more
openaire +2 more sources
FEBS Open Bio, EarlyView.The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti +5 more
wiley +1 more source
Bone & Joint ResearchAims: Recombinant human bone morphogenetic protein-2 (rhBMP-2) is used clinically for bone regeneration. The Food and Drug Administration-approved clinical product (Infuse) is Chinese hamster ovary (CHO)-derived, but Escherichia coli (EC)-derived rhBMP-2
Charles Matthews +3 more
doaj +1 more source
GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma
FEBS Open Bio, EarlyView.GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain +11 more
wiley +1 more source
Research progress on the role of NLRP3 inflammasome in bone homeostasis regulation
Shiyong laonian yixueNucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome is a crucial effector complex of the innate immune system and has recently been recognized as playing a key role in regulating bone homeostasis.
LIU Yanling, ZHOU Ping
doaj +1 more source
Cell surface CD11c as a neutrophil aging marker molecule
FEBS Open Bio, EarlyView.Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki +5 more
wiley +1 more source
Long-term Consequences of Traumatic Brain Injury in Bone Metabolism
Frontiers in Neurology, 2018 Traumatic brain injury (TBI) leads to long-term cognitive, behavioral, affective deficits, and increase neurodegenerative diseases. It is only in recent years that there is growing awareness that TBI even in its milder form poses long-term health ...
Nikita M. Bajwa +5 more
doaj +1 more source
IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo
FEBS Open Bio, EarlyView.To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley +1 more source
Statin: A boon in periodontal therapy
SRM Journal of Research in Dental Sciences, 2015 Periodontitis is an inflammatory process causing gradual destruction of the periodontal tissues and alveolar bone loss. Various periodontal therapies have been introduced to lower the destruction, statin being one among them.
Sahana Purushotham +2 more
doaj +1 more source