Results 61 to 70 of about 7,909,245 (408)

Mechanically induced Ca2+ oscillations in osteocytes release extracellular vesicles and enhance bone formation

Bone Research, 2018
The vast osteocytic network is believed to orchestrate bone metabolic activity in response to mechanical stimuli through production of sclerostin, RANKL, and osteoprotegerin (OPG).
Andrea E. Morrell, Genevieve N. Brown, Samuel T. Robinson, R. L. Sattler, A. Baik, G. Zhen, Xu Cao, Lynda F. Bonewald, Weiyang Jin, Lance C. Kam, X. E. Guo   +10 more
semanticscholar   +1 more source

Heterogeneity in the Global Practice of Central Nervous System Staging in Pediatric Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) involvement in childhood acute lymphoblastic leukemia (ALL) is assessed by cell counting and cytomorphology from cerebrospinal fluid (CSF) and is used for treatment stratification worldwide. The ratio of “CNS2” patients in clinical trials ranges from 3% to 40%, with unclear prognostic significance ...
Laura Almási, Bernadett Borbála Huszti, Gábor Barna, Marko Kavcic, Janez Jazbec, Lennart Lenk, Vera Münch, Sophia Polychronopoulou, Ágnes Márk, Maria Thastrup, Lüder H. Meyer, Kjeld Schmiegelow, Cornelia Eckert, Christina Halsey, Dániel J. Erdélyi   +14 more
wiley   +1 more source

The short-chain fatty acid receptors Gpr41/43 regulate bone mass by promoting adipogenic differentiation of mesenchymal stem cells

Frontiers in Endocrinology
Bone is a dynamic tissue that is constantly remodeled throughout adult life. Recently, it has been shown that bone turnover decreases shortly after food consumption. This process has been linked to the fermentation of non-digestible food ingredients such
Friederike Behler-Janbeck, Anke Baranowsky, Timur A. Yorgan, Michelle Y. Jaeckstein, Anna Worthmann, Marceline M. Fuh, Karthikeyan Gunasekaran, Gisa Tiegs, Michael Amling, Thorsten Schinke, Joerg Heeren   +10 more
doaj   +1 more source

Periosteal Bone Formation on Medullary Evacuation: A Bone Formation Model

Upsala Journal of Medical Sciences, 1972
AbstractA periosteal bone formation model based on the collateral reaction of the periosteum to evacuation of the medullary cavity has been developed. With this experimental model and on the basis of the values obtained and the precise statistical findings made in this study, further investigations on the influence of pharmacological and hormonal ...
G, Danckwardt-Lillieström, S, Grevsten, H, Johansson, S, Olerud   +3 more
openaire   +2 more sources

Implantation of silicon dioxide-based nanocrystalline hydroxyapatite and pure phase beta-tricalciumphosphate bone substitute granules in caprine muscle tissue does not induce new bone formation

, 2013
Background: Osteoinductive bone substitutes are defined by their ability to induce new bone formation even at heterotopic implantation sites. The present study was designed to analyze the potential osteoinductivity of two different bone substitute ...
Künzel, Oliver, Shahram Ghanaati, Ines Willershausen, Ghanaati, Shahram Michael, Samuel E. Udeabor, Robert A. Sader, Oliver Kuenzel, Sader, Robert Alexander, Udeabor, Samuel Ebele, Kirkpatrick, Charles James, C. James Kirkpatrick, Willershausen, Ines Bettina Anne, Mike Barbeck, Barbeck, Mike   +13 more
core   +1 more source

Overexpression of MiR-335-5p Promotes Bone Formation and Regeneration in Mice

Journal of Bone and Mineral Research, 2017
MicroRNAs (miRNAs) and the Wnt signaling pathway play critical roles in regulating bone development and homeostasis. Our previous study revealed high expression of miR‐335‐5p in osteoblasts and hypertrophic chondrocytes in mouse embryos and the ability ...
Lan Zhang, Y. Tang, Xiaofang Zhu, Tianchi Tu, Lei Sui, Qianqian Han, Liming Yu, S. Meng, Leilei Zheng, Paloma Valverde, Jean Tang, D. Murray, Xuedong Zhou, H. Drissi, M. Dard, Q. Tu, J. Chen   +16 more
semanticscholar   +1 more source

Increased Risk of Sarcomas in Children With Congenital Anomalies: Findings From the Genetic Overlap Between Anomalies and Cancer in Kids (GOBACK) Registry Linkage Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Pediatric sarcomas are a heterogeneous group of tumors that contribute disproportionately to cancer mortality in children. Although congenital anomalies are among the strongest known risk factors for childhood cancer, the risk of specific sarcoma subtypes among affected individuals has not yet been thoroughly evaluated. Procedure We
Russ Wolters, Ji Yun Tark, Tiffany M. Chambers, Tania A. Desrosiers, Michael E. Scheurer, Charles Shumate, Wendy N. Nembhard, Mahsa M. Yazdy, Eirini Nestoridi, Amanda E. Janitz, Jean Paul Tanner, Russell S. Kirby, Jason L. Salemi, Yao Yu, Chad D. Huff, Sharon E. Plon, Philip J. Lupo, Jeremy M. Schraw   +17 more
wiley   +1 more source

A mechanistic review of chinese medicine polyphenols on bone formation and resorption

Frontiers in Pharmacology, 2022
Bone reconstruction includes a steady state system of bone formation and bone absorption. This tight coupling requires subtle coordination between osteoblasts and osteoclasts.
Yan Li, Lingyu Li, Lingyu Li, Lingyu Li, Xiaoyun Li, Bingjie Luo, Qianyun Ye, Haoyu Wang, Li Yang, Li Yang, Xiaofeng Zhu, Xiaofeng Zhu, Li Han, Li Han, Ronghua Zhang, Ronghua Zhang, Ronghua Zhang, Huaqin Tian, Panpan Wang, Panpan Wang, Panpan Wang   +20 more
doaj   +1 more source

Osteoclast-derived exosomal miR-214-3p inhibits osteoblastic bone formation

Nature Communications, 2016
Emerging evidence indicates that osteoclasts direct osteoblastic bone formation. MicroRNAs (miRNAs) have a crucial role in regulating osteoclast and osteoblast function.
Defang Li, Jin Liu, B. Guo, C. Liang, L. Dang, Cheng Lu, Xiaojuan He, H. Y. Cheung, Liang Xu, Changwei Lu, Bing He, Biao Liu, A. Shaikh, Fangfei Li, Luyao Wang, Zhijun Yang, D. Au, S. Peng, Zongkang Zhang, Bao-Ting Zhang, Xiao-hua Pan, A. Qian, P. Shang, Lianbo Xiao, B. Jiang, C. Wong, Jiake Xu, Zhaoxiang Bian, Zicai Liang, D. Guo, Hailong Zhu, W. Tan, Aiping Lu, Ge Zhang   +33 more
semanticscholar   +1 more source

Osteocyte-Related Cytokines Regulate Osteoclast Formation and Bone Resorption

International Journal of Molecular Sciences, 2020
The process of bone remodeling is the result of the regulated balance between bone cell populations, namely bone-forming osteoblasts, bone-resorbing osteoclasts, and the osteocyte, the mechanosensory cell type.
H. Kitaura, Aseel Marahleh, Fumitoshi Ohori, Takahiro Noguchi, Wei-Ren Shen, Jiawei Qi, Yasuhiko Nara, Adya Pramusita, Ria Kinjo, I. Mizoguchi   +9 more
semanticscholar   +1 more source