Results 41 to 50 of about 699,964 (265)

The hepcidin regulator erythroferrone is a new member of the erythropoiesis-iron-bone circuitry

eLife, 2021
Background: Erythroblast erythroferrone (ERFE) secretion inhibits hepcidin expression by sequestering several bone morphogenetic protein (BMP) family members to increase iron availability for erythropoiesis.
Melanie Castro-Mollo, Sakshi Gera, Marc Ruiz-Martinez, Maria Feola, Anisa Gumerova, Marina Planoutene, Cara Clementelli, Veena Sangkhae, Carla Casu, Se-Min Kim, Vaughn Ostland, Huiling Han, Elizabeta Nemeth, Robert Fleming, Stefano Rivella, Daria Lizneva, Tony Yuen, Mone Zaidi, Yelena Ginzburg   +18 more
doaj   +1 more source

Clinical, Histopathological, and Molecular Characterization of Pediatric MN1::ZNF341‐Associated Cancer

Pediatric Blood &Cancer, EarlyView.
ABSTRACT A lethal round‐cell malignancy with an MN1::ZNF341 fusion has recently been reported in three infants. Here, we describe four further tumors, three in newborns (including monozygotic twins), and one in an adolescent. Detailed clinical, radiological, and histopathological data differentiate these tumors from their main mimics, neuroblastoma and
Thomas R. W. Oliver, Dyanne Rampling, Barbara Walkowiak, Nathaniel D. Anderson, Manas Dave, Henry Lee‐Six, Sadie Baskind, Pooja Balasubramanian, Glenn Anderson, Conor Parks, Toochi Ogbonnah, Emilia R. Robertson, Simon Hannam, Rohan Verma, John C. Achermann, Liina Palm, Neil Sebire, Thomas Jacques, Tom Watson, Carryl Dryden, Karin Straathof, Mette Jorgensen, Olga Slater, Sam Behjati, Sarita Depani, J. Ciaran Hutchinson   +25 more
wiley   +1 more source

Effective Oral Delivery of Teriparatide Using Organoclay—Polymethacrylate Nanocomposites for Osteoporosis Therapy

Pharmaceutics
Background: Although teriparatide is efficacious, its once-daily subcutaneous injections cause local adverse events, inconvenience, and higher cost, limiting long-term adherence.
Gyu Lin Kim, Yeon Ju Kang, Soo Hwa Seo, Jiwoon Jeon, Hyo-Kyung Han   +4 more
doaj   +1 more source

Impact of Metastatic Patterns on Survival and Response to Therapy in Neuroblastoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background While the presence of metastases in neuroblastoma (NB) is a well‐established prognostic factor, the clinical significance of dissemination patterns and tumour burden and their impact on response and survival remains poorly understood.
Mariona Morell‐Daniel, Santiago Pérez‐Hoyos, Aroa Soriano, Ana Coma, Amalia Varo, Raquel Hladun, Gabriela Guillén, Soraya Mico, Marta Garrido, Lourdes Rubio, Alba Rubio‐San‐Simón, Ana Minguez, Ricardo López‐Almaraz, Laura Illade, Miguel F. Segura, Lucas Moreno   +15 more
wiley   +1 more source

On Hierarchical Composite Endpoints in Pediatric Cancer Supportive Care: Illustrative Examples From Two Multi‐Center Phase‐III Randomized Clinical Trials

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric supportive care clinical trials often involve multiple clinically important outcomes, complicating trial interpretation. Hierarchical composite endpoints (HCEs) provide a framework to integrate key outcomes according to clinical importance.
Willem H. Collier, Mark Zobeck, Adam J. Esbenshade, Christopher C. Dvorak, Lillian Sung, David Freyer, Sarah Alexander, Etan Orgel, Nicole J. Ullrich, Zach Prudowsky, Brian Fisher, Caitlin W. Elgarten   +11 more
wiley   +1 more source

Could CH₃-M6P Be a Potential Dual-Functioning Candidate for Bone Regeneration?

Biomedicines
Background: CI-RM6P has different binding sites with affinities for both M6P and IGF2, plays a role in the regulation of the TGF-β and IGF pathways that is important for controlling cell growth and differentiation.
Fidan Huseynova, Cătălina Ionescu, Frederic Cuisinier, Irada Huseynova, Alamdar Mammadov, Véronique Barragan-Montero   +5 more
doaj   +1 more source

A mechanistic review of chinese medicine polyphenols on bone formation and resorption

Frontiers in Pharmacology, 2022
Bone reconstruction includes a steady state system of bone formation and bone absorption. This tight coupling requires subtle coordination between osteoblasts and osteoclasts.
Yan Li, Lingyu Li, Lingyu Li, Lingyu Li, Xiaoyun Li, Bingjie Luo, Qianyun Ye, Haoyu Wang, Li Yang, Li Yang, Xiaofeng Zhu, Xiaofeng Zhu, Li Han, Li Han, Ronghua Zhang, Ronghua Zhang, Ronghua Zhang, Huaqin Tian, Panpan Wang, Panpan Wang, Panpan Wang   +20 more
doaj   +1 more source

FORMATION OF THE FLAT BONES. [PDF]

The Lancet
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openaire   +1 more source

The Role of Chemotherapy in Pediatric Myoepithelial Carcinoma: A Systematic Review of the Literature

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Myoepithelial carcinoma (MEC) in pediatric patients is a rare and aggressive malignancy characterized by heterogeneous morphology and variable molecular features. The optimal role of chemotherapy remains unclear. We conducted a systematic review according to PRISMA 2020 guidelines to evaluate chemotherapy in pediatric and young‐adult patients ...
Marco Salvi, Maria Carmen Affinita, Giulia Fichera, Luisa Santoro, Angela Scagnellato, Calogero Virgone, Elena Poli, Gianni Bisogno   +7 more
wiley   +1 more source

Green Tea Extract Containing Epigallocatechin-3-Gallate Facilitates Bone Formation and Mineralization by Alleviating Iron-Overload-Induced Oxidative Stress in Human Osteoblast-like (MG-63) Cells

Antioxidants
Secondary iron overload exacerbates osteoporosis by elevating reactive oxygen species (ROS), which suppress osteoblast function and enhance osteoclast activity, disrupting bone remodeling.
Honghong Xu, Orawan Khantamat, Woranontee Korsieporn, Narisara Paradee, Jin Li, Yanping Zhong, Somdet Srichairatanakool, Pimpisid Koonyosying   +7 more
doaj   +1 more source