Results 21 to 30 of about 1,355,503 (353)
Differential involvement of Wnt signaling in Bmp regulation of cancellous versus periosteal bone growth [PDF]
, 2017 Bone morphogenetic proteins (Bmp) are well-known to induce bone formation following chondrogenesis, but the direct role of Bmp signaling in the osteoblast lineage is not completely understood.
Bellido, Teresita +5 more
core +3 more sources
Frontiers in Pharmacology, 2021 Postmenopausal osteoporosis is a disease of bone mass reduction and structural changes due to estrogen deficiency, which can eventually lead to increased pain and fracture risk. Chronic inflammatory microenvironment leading to the decreased activation of
Gaoran Ge +10 more
doaj +1 more source
The Role of Intestinal Flora in the Regulation of Bone Homeostasis
Frontiers in Cellular and Infection Microbiology, 2021 Intestinal flora located within the intestinal tract comprises a large number of cells, which are referred to as the second gene pool of the human body and form a complex symbiotic relationship with the host.
Chengxiang Li, Guofu Pi, Feng Li
doaj +1 more source
Frontiers in Endocrinology, 2020 Immobilization results in a substantial bone loss and increased fracture risk. Powerful bone anabolic therapies are necessary to counteract the bone loss and reduce fracture risk during periods with immobilization.
Mikkel Bo Brent +2 more
doaj +1 more source
Effects of erythropoietin on osteoblast in the tooth extraction socket in mice periodontitis model
Frontiers in Physiology, 2022 Periodontitis is an excessive inflammatory event in tooth-supporting tissues and can cause tooth loss. We used erythropoietin (EPO), which has been reported to play an important role in bone healing and modulation of angiogenesis, as a therapeutic agent ...
Ju-Eun Bae +13 more
doaj +1 more source
Genetic basis for skeletal new bone formation [PDF]
Exploration of Musculoskeletal Diseases, 2023 Bone formation is a complex process that occurs throughout life, and is normally limited to the skeletal system. In bone formation, osteoprogenitor cells follow several developmental stages, including differentiation in osteoblasts, proliferation, matrix
Bruna Parreira +3 more
doaj +1 more source
Sclerostin inhibition alleviates breast cancer-induced bone metastases and muscle weakness [PDF]
, 2019 Breast cancer bone metastases often cause a debilitating non-curable condition with osteolytic lesions, muscle weakness and a high mortality. Current treatment comprises chemotherapy, irradiation, surgery and anti-resorptive drugs that restrict but do ...
Brandt, Diana +5 more
core +1 more source
The hepcidin regulator erythroferrone is a new member of the erythropoiesis-iron-bone circuitry
eLife, 2021 Background: Erythroblast erythroferrone (ERFE) secretion inhibits hepcidin expression by sequestering several bone morphogenetic protein (BMP) family members to increase iron availability for erythropoiesis.
Melanie Castro-Mollo +18 more
doaj +1 more source
Factors stimulating bone formation [PDF]
European Spine Journal, 2001 The aim of this review is to describe major approaches for stimulating bone healing and to review other factors affecting bone healing. Spinal bone fusion after surgery is a demanding process requiring optimal conditions for clinical success. Bone formation and healing can be enhanced through various methods. Experimental studies have revealed an array
Lind, Martin, Bünger, Cody
openaire +3 more sources
Analysis of Nkx3.1:Cre-driven Erk5 deletion reveals a profound spinal deformity which is linked to increased osteoclast activity [PDF]
, 2017 Extracellular signal-regulated protein kinase 5 (ERK5) has been implicated during development and carcinogenesis. Nkx3.1-mediated Cre expression is a useful strategy to genetically manipulate the mouse prostate. While grossly normal at birth, we observed
Ahmad, Imran +15 more
core +2 more sources