Results 111 to 120 of about 399,329 (296)

Macrophage-Derived Extracellular Vesicles as Carriers of Alarmins and Their Potential Involvement in Bone Homeostasis

Frontiers in Immunology, 2019
Extracellular vesicles are a heterogeneous group of cell-derived membranous structures, which facilitate intercellular communication. Recent studies have highlighted the importance of extracellular vesicles in bone homeostasis, as mediators of crosstalk ...
Bartijn C. H. Pieters, Alfredo Cappariello, Martijn H. J. van den Bosch, Peter L. E. M. van Lent, Anna Teti, Fons A. J. van de Loo   +5 more
doaj   +1 more source

Macrophage Membrane‐Camouflaged Nanozyme Microneedles Restore Immunovascular Homeostasis Through SPP1‐ApoE Signaling in Diabetic Wounds

Advanced Healthcare Materials, EarlyView.
Macrophage membrane‐coated Cu/Zn‐MOF nanozyme microneedles (MNs) reprogram the diabetic wound microenvironment through localized, minimally invasive delivery. By suppressing M1‐like macrophage activation while promoting extracellular matrix deposition and angiogenesis, this biomimetic platform accelerates diabetic wound repair.
Qipeng Wu, Yuan Xiong, Li Lu, Han Wang, Hui Hu, Mohammad‐Ali Shahbazi, Guohui Liu, Bobin Mi   +7 more
wiley   +1 more source

Urokinase plasminogen activator receptor affects bone homeostasis by regulating osteoblast and osteoclast function [PDF]

, 2007
The uPAR and its ligand uPA are expressed by both osteoblasts and osteoclasts. Their function in bone remodeling is unknown. We report that uPAR-lacking mice display increased BMD, increased osteogenic potential of osteoblasts, decreased osteoclasts ...
P. Verde, F. Furlan, F. Talotta, Rubinacci, Alessandro, Furlan, Federico, N. R. Jorgensen, Galbiati, Clara, Jørgensen, Niklas R, Verde, Pasquale, E. Mrak, F. Blasi, A. Rubinacci, Mrak, Emanuela, Blasi, Francesco, Talotta, Francesco, J. E. Jensen, Jensen, Jens-Erik B, C. Galbiati   +17 more
core   +1 more source

Encoded Cell‐Material Interactions to Reroute Cytokine Signaling for Regenerative Medicine

Advanced Healthcare Materials, EarlyView.
We present native MATRIX (Material Activated To Regulate Inducible gene eXpression), a co‐engineered material‐cell platform. Surfaces functionalized with antibodies for endogenous soluble ligands (e.g., IL‐1β or IL‐6) capture and immobilize ligands for presentation to a cognate, engineered synthetic Notch receptor, releasing a transcription factor (TF)
Zachary M. Eidman, Jhanvi Sharma, Joanne C. Lee, Nicholas F. Schulze, Hannah J. Brien, Kevin C. Corn, Marjan Rafat, Jonathan M. Brunger   +7 more
wiley   +1 more source

Kinases in bone homeostasis: Studies on the roles of AMPKalpha2 and PI3Kgamma in bone homeostasis [PDF]

, 2010
AMPKα2 is a catalytic subunit of AMPK, which is a key regulator for cellular and whole body energy homeostasis. Bone is a dynamic organ and susceptible to metabolic changes. To assess the physiological role of AMPKα2 in bone homeostasis, we characterized
Kang, Heeseog
core  

Role and mechanism of action of Sclerostin in bone [PDF]

, 2017
After discovering that lack of Sost/sclerostin expression is the cause of the high bone mass human syndromes Van Buchem disease and sclerosteosis, extensive animal experimentation and clinical studies demonstrated that sclerostin plays a critical role in
Sato, Amy Y., Bellido, Teresita, Delgado-Calle, Jesus   +2 more
core   +1 more source

Kelvin Probe Force Microscopy in Bionanotechnology: Current Advances and Future Perspectives

Advanced Materials, EarlyView.
Kelvin probe force microscopy (KPFM) enables the nanoscale mapping of electrostatic surface potentials. While widely applied in materials science, its use in biological systems remains emerging. This review presents recent advances in KPFM applied to biological samples and provides a critical perspective on current limitations and future directions for
Ehsan Rahimi, Mario Palacios‐Corella, Arjan Mol, Salvador Pané, Josep Puigmartí‐Luis   +4 more
wiley   +1 more source

Mechanism‐Driven Nanoformulations for Cognitive Impairment Induced by Intermittent Hypoxia and Periodontitis

Advanced Materials, EarlyView.
Clinically, intermittent hypoxia (IH) is often accompanied by periodontitis, which accelerates cognitive impairment induced by IH. Novel Janus mesoporous gold‐silica nanoformulations (RVG‐Au&mSiO2‐TPP‐VB) enable intranasal delivery, achieve hierarchical targeting to neuronal mitochondria, effectively scavenge reactive oxygen species, inhibit the HIF‐1α/
Kai‐Run Zhang, Tianbao Zhu, An‐Qi Liu, Jia‐Jia Deng, Ya‐Li Han, Sheng‐Cai Qi, Xue Liu, Tian‐Yi Jiang, Ming‐Rui Zhai, Yu‐Ying He, Xiu‐Juan Li, Hong‐Ting Da, Rui Xu, Xiaomin Li, Jun Gao, Yue‐Hua Liu   +15 more
wiley   +1 more source

A wheat germ-rich diet preserves bone homeostasis by regulating gut microbiota and plasma metabolites in aged rats

Food Science and Human Wellness
Bone loss caused by ageing has become one of the leading health risk factors worldwide. Wheat germ (WG) is consists of high amounts of bioactive peptides, polyunsaturated fatty acids, and dietary fibre.
Luanfeng Wang, Zebin Weng, Tong Chen, Yu Li, Ling Xiong, Haizhao Song, Fang Wang, Xiaozhi Tang, Bo Ren, Xuebo Liu, Xinchun Shen   +10 more
doaj   +1 more source

Foxp3+ Regulatory T Cells in Bone and Hematopoietic Homeostasis

Frontiers in Endocrinology, 2019
The bone represents surprisingly dynamic structures that are subject to constant remodeling by the concerted action of bone-forming osteoblasts and bone-resorbing osteoclasts - two cell subsets of distinct developmental origin that are key in maintaining
Luise Fischer, Luise Fischer, Caroline Herkner, Reni Kitte, Sebastian Dohnke, Sebastian Dohnke, Julia Riewaldt, Karsten Kretschmer, Annette I. Garbe   +8 more
doaj   +1 more source