Results 221 to 230 of about 555,730 (303)

"OMICS" in Human Milk: Focus on Biological Effects on Bone Homeostasis. [PDF]

Nutrients
Farella I, D'Amato G, Orellana-Manzano A, Segura Y, Vitale R, Clodoveo ML, Corbo F, Faienza MF.   +7 more
europepmc   +1 more source

Bacterial Outer Membrane Vesicles in Potentiating Cancer Vaccines: Progress and Prospects

Advanced Science, EarlyView.
Bacterial outer membrane vesicles (OMVs) have emerged as versatile platforms for cancer vaccine development owing to their intrinsic immunostimulatory properties and high engineering flexibility. This review summarizes OMV biology, immune mechanisms, and engineering strategies that enhance vaccine efficacy, discusses key translational challenges, and ...
Jiabeini Zhang, Tianyu Shao, Fengjiang Qu, Caiyun Bai, Sijie Li, Pin Gao, Wenna Li, Keman Cheng, Xiao Zhao, Zhimin Fan   +9 more
wiley   +1 more source

Loss of the RNA Binding Protein HuR in Early Murine Limb Mesenchyme Does Not Affect Development but Leads to Impaired Bone Homeostasis in Adulthood. [PDF]

FASEB J
Fu S, Johnson KA, Winstanley-Zarach P, Ersoy U, Adlmanninger E, McDermott BT, Keenan C, Vasilaki A, Kanakis I, Milner PI, Van't Hof RJ, Kontoyiannis D, Bou-Gharios G, Turner DA, Tew SR.   +14 more
europepmc   +1 more source

mTOR signaling in skeletal development and disease [PDF]

, 2018
Chen, Jianquan, Long, Fanxin
core   +1 more source

ZMAT1 Promotes Osteoclastogenesis Through TRIM46 Mediated YAP1 Degradation and Inhibits Osteoblastogenesis

Advanced Science, EarlyView.
Zmat1 deficiency mitigates pathological bone loss by impairing osteoclastogenesis and promoting osteoblastogenesis. Mechanistically, in osteoclasts, Zmat1 loss relieves transcriptional repression of the E3 ligase TRIM46, promoting YAP1 degradation and inhibiting osteoclastogenic genes.
Xinyu Chang, Yijin Hou, Likun Cui, Huiqi Yu, Rong Liu, Junhao Sui, Zhong Zheng, Lu Liu, Jie Chen, Mengchen Chen, Chen Ding, Shuogui Xu, Sheng Xu, Hao Zhang   +13 more
wiley   +1 more source

The role of the unfolded protein response pathway in bone homeostasis and potential therapeutic target in cancer-associated bone disease. [PDF]

Bone Res
Muehlebach ME, Holstein SA.
europepmc   +1 more source

Beyond Extracellular Vesicle (EV) Hype: Practical Solutions and Remaining Hurdles in EV Research, Manufacturing, and Clinical Translation

Advanced Science, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are nanoscale mediators of intercellular communication with diverse molecular cargoes that reflect their cell of origin. Advances in isolation, detection, and single‐particle analytics have revealed increasing molecular and functional heterogeneity, while exposing limitations in how EV identity and activity are ...
David J. Lundy, Zoe L. Chau, Sheng‐You Chen, Nanami Fujisawa, John J. Hill, Barnett M. Hsu, Joanne K. Liu, Karol W. Mai, James J. Lai   +8 more
wiley   +1 more source

Bioactive Compounds from Propolis on Bone Homeostasis: A Narrative Review. [PDF]

Antioxidants (Basel)
Bertolucci V, Ninomiya AF, Longato GB, Kaneko LO, Nonose N, Scariot PPM, Messias LHD.   +6 more
europepmc   +1 more source

Lipoic Acid‐Intervened Decellularized Stem Cell Spheroid‐Based Injectable Granular Gel for Diabetic Tissue Regeneration

Advanced Science, EarlyView.
ABSTRACT Advancements in tissue engineering have revolutionized therapeutic paradigms for diabetic tissue defects; however, the lack of applicable scaffold containing various bioactive substance aggregates remained a critical bottleneck hindering satisfactory repair effect.
Tao Wang, Haowei Fang, Lili Qi, Song Myoungseop, Aawrish Khan, Lunli Gong, Guangdong Zhou, Kunxi Zhang, Haiyan Cui   +8 more
wiley   +1 more source

Endothelial-to-Osteoblast Conversion maintains bone homeostasis through Kindlin-2/Piezo1/TGFβ/Runx2 axis. [PDF]

Protein Cell
Ma G, Han Y, Tang W, Zhou B, Chen L, Ding Z, Cheng S, Chen D, Cao H.   +8 more
europepmc   +1 more source