Results 31 to 40 of about 374,545 (305)

Benincasa hispida Extract Prevents Ovariectomy-Induced Osteoporosis in Female ICR Mice

Applied Sciences, 2023
With the increase in bone metabolic diseases owing to the aging of the global population, interest in functional food ingredients for improving bone health is increasing.
Sun-Il Choi, Xionggao Han, Xiao Men, Se-Jeong Lee, Geon Oh, Ye-Eun Choi, Jung-Mo Yang, Ju-Hyun Cho, Ok-Hwan Lee   +8 more
doaj   +1 more source

RANKL in bone homeostasis [PDF]

Science, 2018
Physiology![Figure][1] Osteoporosis reduces bone density because of imbalances in signaling feedbacks. PHOTO: ALAN BOYDE/VISUALS UNLIMITED, INC. Synthesis and breakdown of bone are tightly coupled to preserve skeletal function. Ikebuchi et al. show that signaling via a transmembrane receptor protein called receptor activator of nuclear factor–kappa
openaire   +1 more source

Adverse Impact of Heavy Metals on Bone Cells and Bone Metabolism Dependently and Independently through Anemia

Advanced Science, 2020
Mounting evidence is revealing that heavy metals can incur disordered bone homeostasis, leading to the development of degenerative bone diseases, including osteoporosis, osteoarthritis, degenerative disk disease, and osteomalacia.
Shuping Zhang, Li Sun, Jie Zhang, Sijin Liu, Jinxiang Han, Yajun Liu   +5 more
doaj   +1 more source

The Programmed Death-1 Pathway Counter-Regulates Inflammation-Induced Osteoclast Activity in Clinical and Experimental Settings

Frontiers in Immunology, 2022
ObjectiveThe programmed death-1 (PD-1) pathway is essential for maintaining self-tolerance and plays an important role in autoimmunity, including rheumatoid arthritis (RA).
Stinne R. Greisen, Stinne R. Greisen, Tue W. Kragstrup, Tue W. Kragstrup, Jesper Skovhus Thomsen, Kim Hørslev-Pedersen, Merete Lund Hetland, Merete Lund Hetland, Kristian Stengaard-Pedersen, Mikkel Østergaard, Mikkel Østergaard, Lykke Ørnbjerg, Peter Junker, Arlene H. Sharpe, Gordon J. Freeman, Malene Hvid, Malene Hvid, Søren K. Moestrup, Ellen Margrethe Hauge, Ellen Margrethe Hauge, Bent Deleuran, Bent Deleuran   +21 more
doaj   +1 more source

RANKL-Induced Btn2a2 – A T Cell Immunomodulatory Molecule – During Osteoclast Differentiation Fine-Tunes Bone Resorption

Frontiers in Endocrinology, 2021
Butyrophilins, which are members of the extended B7 family of immunoregulators structurally related to the B7 family, have diverse functions on immune cells as co-stimulatory and co-inhibitory molecules.
Michael Frech, Michael Frech, Gregor Schuster, Gregor Schuster, Fabian T. Andes, Fabian T. Andes, Georg Schett, Georg Schett, Mario M. Zaiss, Mario M. Zaiss, Kerstin Sarter, Kerstin Sarter   +11 more
doaj   +1 more source

Bone morphogenic proteins in iron homeostasis

Bone, 2020
The bone morphogenetic protein (BMP)-SMAD signaling pathway plays a central role in regulating hepcidin, which is the master hormone governing systemic iron homeostasis. Hepcidin is produced by the liver and acts on the iron exporter ferroportin to control iron absorption from the diet and iron release from body stores, thereby providing adequate iron ...
Xia, Xiao, Víctor M, Alfaro-Magallanes, Jodie L, Babitt   +2 more
openaire   +3 more sources

Fibroblast Activation Protein Is Expressed by Altered Osteoprogenitors and Associated to Disease Burden in Fibrous Dysplasia

Cells
Fibrous dysplasia (FD) is a mosaic skeletal disorder involving the development of benign, expansile fibro-osseous lesions during childhood that cause deformity, fractures, pain, and disability. There are no well-established treatments for FD.
Layne N. Raborn, Zachary Michel, Michael T. Collins, Alison M. Boyce, Luis F. de Castro   +4 more
doaj   +1 more source

Hypoxia-Inducible Factors Regulate Osteoclasts in Health and Disease

Frontiers in Cell and Developmental Biology, 2021
Hypoxia-inducible factors (HIFs) have become key transcriptional regulators of metabolism, angiogenesis, erythropoiesis, proliferation, inflammation and metastases. HIFs are tightly regulated by the tissue microenvironment.
Xianyi Meng, Ben Wielockx, Martina Rauner, Aline Bozec   +3 more
doaj   +1 more source

In Search of a Role for Extracellular Purine Enzymes in Bone Function

Biomolecules, 2021
Bone is one of the major tissues that undergoes continuous remodeling throughout life, thus ensuring both organic body growth during development and protection of internal organs as well as repair of trauma during adulthood.
Mariachiara Zuccarini, Patricia Giuliani, Francesco Caciagli, Renata Ciccarelli, Patrizia Di Iorio   +4 more
doaj   +1 more source

MicroRNAs as regulators of bone homeostasis and bone metastasis [PDF]

bonekey Reports, 2014
MicroRNAs (miRNAs) are short, endogenous RNAs that have essential roles in regulating gene expression through the disruption of target genes. The miRNA-induced suppression can occur through Argonaute-mediated cleavage of target mRNAs or by translational inhibition.
Brian, Ell, Yibin, Kang
openaire   +2 more sources