Results 41 to 50 of about 374,545 (305)

Distinct Glucocorticoid Receptor Actions in Bone Homeostasis and Bone Diseases

Frontiers in Endocrinology, 2022
Glucocorticoids (GCs) are steroid hormones that respond to stress and the circadian rhythm. Pharmacological GCs are widely used to treat autoimmune and chronic inflammatory diseases despite their adverse effects on bone after long-term therapy. GCs regulate bone homeostasis in a cell-type specific manner, affecting osteoblasts, osteoclasts, and ...
Lee, Sooyeon, Krüger, Benjamin Thilo, Ignatius, Anita, Tuckermann, Jan   +3 more
openaire   +4 more sources

Oral microbiome, periodontal disease and systemic bone-related diseases in the era of homeostatic medicine

Journal of Advanced Research
Background: Homeostasis is a state of self-regulation and dynamic equilibrium, maintaining the good physiological functions of each system in living organisms.
Weiqi Hu, Shuoling Chen, Xianghui Zou, Yan Chen, Jiayu Luo, Peiliang Zhong, Dandan Ma   +6 more
doaj   +1 more source

l-Type amino acid transporter 1 in hypothalamic neurons in mice maintains energy and bone homeostasis

JCI Insight, 2023
Hypothalamic neurons regulate body homeostasis by sensing and integrating changes in the levels of key hormones and primary nutrients (amino acids, glucose, and lipids). However, the molecular mechanisms that enable hypothalamic neurons to detect primary
Gyujin Park, Kazuya Fukasawa, Tetsuhiro Horie, Yusuke Masuo, Yuka Inaba, Takanori Tatsuno, Takanori Yamada, Kazuya Tokumura, Sayuki Iwahashi, Takashi Iezaki, Katsuyuki Kaneda, Yukio Kato, Yasuhito Ishigaki, Michihiro Mieda, Tomohiro Tanaka, Kazuma Ogawa, Hiroki Ochi, Shingo Sato, Yun-Bo Shi, Hiroshi Inoue, Hojoon Lee, Eiichi Hinoi   +21 more
doaj   +1 more source

Experience with ospemifene in patients with vulvar and vaginal atrophy: case studies with bone marker profiles

Drugs in Context, 2020
Selective estrogen receptor modulators (SERMs) exhibit varying agonist/antagonist activities on estrogen receptors in tissues, although most SERMs, including ospemifene, have agonist effects on bone.
María del Carmen Pingarrón Santofimia, Silvia Pilar González Rodríguez, Mariella Lilue, Santiago Palacios   +3 more
doaj   +1 more source

Basolateral Amygdala Mediates Central Mechanosensory Feedback of Musculoskeletal System

Frontiers in Molecular Neuroscience, 2022
Musculoskeletal diseases, such as osteoporosis and sarcopenia, are tremendous and growing public health concerns. Considering the intimate functional relationship between muscle and bone throughout development, growth, and aging, muscle provides the ...
Nian Liu, Nian Liu, Botai Li, Botai Li, Lu Zhang, Dazhi Yang, Fan Yang   +6 more
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

RANKL inhibition reduces lesional cellularity and Gαs variant expression and enables osteogenic maturation in fibrous dysplasia

Bone Research
Fibrous dysplasia (FD) is a rare, disabling skeletal disease for which there are no established treatments. Growing evidence supports inhibiting the osteoclastogenic factor receptor activator of nuclear kappa-B ligand (RANKL) as a potential treatment ...
Luis F. de Castro, Jarred M. Whitlock, Zachary Michel, Kristen Pan, Jocelyn Taylor, Vivian Szymczuk, Brendan Boyce, Daniel Martin, Vardit Kram, Rebeca Galisteo, Kamran Melikov, Leonid V. Chernomordik, Michael T. Collins, Alison M. Boyce   +13 more
doaj   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Aromatase Activity and Bone Homeostasis in Men [PDF]

The Journal of Clinical Endocrinology & Metabolism, 2004
It is known that sex steroid hormones play an important role in the maintenance of bone mass in males as well as in females. Even though androgens are the major sex steroids in men, their primacy in regulating male skeletal remodeling has been increasingly questioned as direct and indirect evidence emerged suggesting that estrogens may also play a ...
GENNARI, LUIGI, NUTI, RANUCCIO, Bilezikian J.P.   +2 more
openaire   +4 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source