Results 81 to 90 of about 1,552,377 (310)
6'-Methoxy Raloxifene-analog enhances mouse bone properties with reduced estrogen receptor binding [PDF]
, 2020 Raloxifene (RAL) is an FDA-approved drug used to treat osteoporosis in postmenopausal women. RAL suppresses bone loss primarily through its role as a selective estrogen receptor modulator (SERM).
Allen, Matthew R. +9 more
core +1 more source
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
The CD163/TWEAK/Fn14 axis: A potential therapeutic target for alleviating inflammatory bone loss
Journal of Orthopaedic TranslationObjective: Osteoclast (OC) over-activation is an important cause of bone loss that is strongly correlated with inflammation. Although the CD163/TWEAK/Fn14 axis has been implicated in several inflammatory pathologies, its contributions to inflammatory ...
Ji-kun Qian +19 more
doaj +1 more source
Frontiers in Pharmacology, 2018 The Yi Shen Juan Bi Pill (YSJB), a traditional Chinese compound herbal drug, has been used as an anti-rheumatic drug in clinical practice. Cartilage and bone destruction of inflamed joints is the hallmark of rheumatoid arthritis (RA).
Hongyan Zhao +9 more
doaj +1 more source
Different Loading Times for Dental Implants: No Clinically Important Differences? [PDF]
, 2013 Data sources The Cochrane Oral Health Group\u27s Trials Register, the Cochrane Central Register of Controlled Trials (CENTRAL), Medline, and Embase databases were searched.
Stafford, Gary L
core +1 more source
Bone Loss and Inhaled Glucocorticoids
New England Journal of Medicine, 2002 Comparisons between patients with mild asthma and those with persistent asthma who are receiving high doses of inhaled glucocorticoids must include a careful evaluation of base-line characteristics.2 Table 2 of the article shows that the 28 women who did not use inhaled glucocorticoids weighed less than the 42 women who required more than eight puffs ...
van Staa, Tjeerd-Pieter +2 more
openaire +3 more sources
Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer
Aging and Cancer, EarlyView.Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss +12 more
wiley +1 more source
Marginal bone loss around implants placed in maxillary native bone or grafted sinuses: a retrospective cohort study [PDF]
, 2013 Objectives To assess differences in marginal bone loss around implants placed in maxillary pristine bone and implants placed following maxillary sinus augmentation over a period of 3 years after functional loading.
Avila‐ortiz, G. +5 more
core +1 more source
Aging and Cancer, EarlyView.This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel +4 more
wiley +1 more source
Bone & Joint OpenAims: Revision hip arthroplasty for femoral stem loosening remains challenging due to significant bone loss and deformities requiring specialized revision stems. The aim of this study was to evaluate the clinical and radiological outcomes, and survival,
Antonino G. Battaglia +5 more
doaj +1 more source