Results 81 to 90 of about 4,190,471 (295)

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

The CD163/TWEAK/Fn14 axis: A potential therapeutic target for alleviating inflammatory bone loss

Journal of Orthopaedic Translation
Objective: Osteoclast (OC) over-activation is an important cause of bone loss that is strongly correlated with inflammation. Although the CD163/TWEAK/Fn14 axis has been implicated in several inflammatory pathologies, its contributions to inflammatory ...
Ji-kun Qian, Yuan Ma, Xuan Huang, Xiao-ran Li, Ya-fei Xu, Zi-ying Liu, Yuan Gu, Ke Shen, Liang-jie Tian, Yu-tian Wang, Ning-ning Cheng, Bing-sheng Yang, Kui-yuan Huang, Yu Chai, Guan-qiao Liu, Nai-qian Cui, Song-yun Deng, Nan Jiang, Dao-rong Xu, Bin Yu   +19 more
doaj   +1 more source

Yi Shen Juan Bi Pill Ameliorates Bone Loss and Destruction Induced by Arthritis Through Modulating the Balance of Cytokines Released by Different Subpopulations of T Cells

Frontiers in Pharmacology, 2018
The Yi Shen Juan Bi Pill (YSJB), a traditional Chinese compound herbal drug, has been used as an anti-rheumatic drug in clinical practice. Cartilage and bone destruction of inflamed joints is the hallmark of rheumatoid arthritis (RA).
Hongyan Zhao, Hongyan Zhao, Huihui Xu, Zhengyun Zuo, Gui Wang, Gui Wang, Meijie Liu, Minghui Guo, Minghui Guo, Cheng Xiao   +9 more
doaj   +1 more source

Modeling Normal Aging Bone Loss, with Consideration of Bone Loss in Osteoporosis [PDF]

Toxicological Sciences, 2000
A physiologically based model of normal bone loss in human aging is presented. The model is a modification of an existing physiologically based model of body and bone growth from birth to maturity. To account for loss of bone after peak bone mass is reached between ages 25 and 30 years, a slow first-order loss of bone is incorporated into the existing ...
openaire   +2 more sources

Bone fractures after menopause [PDF]

, 2010
Every year 30% of individuals above age 65 fall, and falls are the principal cause of bone fractures. To reduce fracture incidence requires both prevention of falls and maintenance of bone strength.PubMed searches were performed, for studies of the ...
Ralston, Stuart H., J. L. Evers, Baird, D. T., A. Volpe, Ralston, S.H., Brandi, M.L., G. Benagiano, Brandi, Maria Luisa, S. H. Ralston, P.G. Crosignani, P. Bouchard, Rizzoli, R., ESHRE Capri Workshop Grp, Barlow, David H., La Vecchia, C., Negri, E., M. L. Brandi, P. G. Crosignani, Rizzoli, Rene, Benagiano, G., S. E. Papapoulos, Evers, J.L.H., D. H. Barlow, J. Collins, C. La Vecchia, Baird, D.T., Negri, Eva, Crosignani, P. G., Papapoulos, Socrates E., Glasier, A., R. Rizzoli, Barlow, D.H., A. Glasier, Vecchia, C. la, Collins, J., D. T. Baird, Volpe, A., Bouchard, P., Crosignani, P.G., Bouchard, Philippe, ?, ?, Papapoulos, S.E., E. Negri, Evers, J. L. H.   +43 more
core   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

The Zweymüller primary stem is a reliable, effective, and less invasive implant in revision hip arthroplasty for Paprosky type I and II defects

Bone & Joint Open
Aims: Revision hip arthroplasty for femoral stem loosening remains challenging due to significant bone loss and deformities requiring specialized revision stems. The aim of this study was to evaluate the clinical and radiological outcomes, and survival,
Antonino G. Battaglia, Rocco D'Apolito, Benjamin T. K. Ding, Stefano Tonolini, Joil Ramazzotti, Luigi Zagra   +5 more
doaj   +1 more source

Muscle loss and bone loss: Master and slave? [PDF]

Bone, 2010
Among the ever-growing list of benefits associated with physical activity, bone and muscle health remain near the top. Exercise improves muscle strength, and simultaneously enhances bone architecture and fracture resistance. The strong association between these two parameters has been explored in greater detail in recent years, to begin to understand ...
openaire   +2 more sources

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

FEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta, Sebastian GB Furness, Tahereh Gharbi, Ric De Paoli‐Iseppi, Shweta S. Joshi, Michael Clark, David L. Hare, Peter Wookey   +7 more
wiley   +1 more source