Results 91 to 100 of about 1,147,375 (265)

Efficacy of Bone Marrow Aspirate Concentrate Versus Platelet-rich Plasma in Knee Osteoarthritis: A Systematic Review and Meta-analysis

Indian Journal of Pain
In knee osteoarthritis (KOA), intra-articular bone marrow aspirate concentrate (IA-BMAC) and platelet-rich plasma (IA-PRP) are widely studied orthobiologic therapies, yet comparative evidence regarding their efficacy remains inconsistent.
Sushpa Das, Gautam Das, Gaurav Sharma, S. Amatya, S. Hota, A. Milton, Prajna Jayaram, Shalina Chandran, Hari Poudel, Vikas Sharma   +9 more
semanticscholar   +1 more source

Targeting β2‐Adrenergic Receptor Stability With Lycorine Reveals a Host‐Directed Pathway for Antiviral Defense Against Poxviruses

Advanced Science, EarlyView.
Chronic stress drives autophagy‐mediated β2‐AR degradation, impairing antiviral immunity and promoting poxvirus lethality. Lycorine directly stabilizes β2‐AR to restore host defense, suppress excessive inflammation and improve survival. ABSTRACT Psychological stress is a pervasive yet poorly understood modulator of infectious disease outcomes. Here, we
Xin Zhang, Shuqin Xu, Zixuan Zhang, Chenwen Wan, Xiaoqin Wang, Peihua Wang, Huini Yang, Tianxiao Huang, Yijia Yuan, Faiza Atique, Rui Yang, Yingli He, Zhijun Liu   +12 more
wiley   +1 more source

Use of bone marrow aspirate concentrate in the treatment of early stages of osteonecrosis of the femoral head

N.N. Priorov Journal of Traumatology and Orthopedics
Background: The use of bone marrow aspirate concentrate for aseptic bone necrosis can improve patient treatment outcomes, as well as delay or avoid joint replacement.
A. Torgashin, A. Baikova, S. Rodionov, S. Rodionova   +3 more
semanticscholar   +1 more source

Macrophage PABPC4‐SPP1 Axis Orchestrates Immunosuppression in Colorectal Cancer

Advanced Science, EarlyView.
In the CRC microenvironment, macrophage PABPC4 binds to the 3′UTR of SPP1 mRNA to stabilize its expression, thereby sustaining M2‐like immunosuppressive macrophage polarization. Concurrently, this axis suppresses CD8+ T cell effector functions via CD44 signaling, collectively fostering an immunosuppressive niche that drives tumor progression.
Meng Wang, Fang Yang, Yuan Gao, Liuli Li, Yulan Huang, Hui Yao, Sijie Zhao, Kun Zhao, Tianying Zhang, Hui Heng, Jiaxin Xu, Yuancai Xiang, Weidong Xiao, Shaofan Hu, Hongming Miao   +14 more
wiley   +1 more source

Hyper‐Intense Tumor Peripheral Accumulation of Antibody‐Conjugated Iron Oxide Nanoparticles can Enable Breast Cancer Detection by Magnetic Particle Imaging

Advanced Science, EarlyView.
Tumor‐associated inflammation retains antibody‐targeted or non‐specific antibody conjugated nanoparticles within the tumor microenvironment. Magnetic Particle Imaging (MPI) enables non‐invasive detection and differentiation of tumors from other organs, owing to higher nanoparticle retention by inflammatory cells in the tumor periphery.
Preethi Korangath, Hayden Carlton, Theresa Wong, Sean Healy, Toby Sanders, Mason Song, Patrick W. Goodwill, Cordula Grüttner, Kathleen Gabrielson, Robert Ivkov   +9 more
wiley   +1 more source

Efficacy and safety of bone marrow aspirate and bone marrow aspirate concentrate in orthopedic conditions: a systematic review of randomized controlled trials

Frontiers in Surgery
IntroductionBone marrow aspirate (BMA) and bone marrow aspirate concentrate (BMAC) have emerged as autologous orthobiologic strategies aimed at modulating inflammation and promoting tissue repair in orthopedic conditions.
Joelington Dias Batista, Ludimila Dias Silva, Jobson Dias Batista, Gabrielly Santos Pereira, Marcelo Lourenço da Silva   +4 more
doaj   +1 more source

Reversing Macrophage Immunometabolic Dysfunction in Prolonged Infections Via a Glutaminolysis‐Fueled Restoration‐Based Hierarchically Selective Therapeutic System

Advanced Science, EarlyView.
A hierarchically selective immunotherapeutic nanoplatform, mGls@HEV‐MTP, selectively restores macrophage immunocompetence through GLS1‐mediated restoration of glutaminolysis‐fueled anaplerosis. Concurrently, it renders Staphylococcus aureus (S. aureus) more readily recognizable to the metabolically reprogrammed macrophages, thereby facilitating ...
Weinan Yang, Zihao An, Honglu Cai, Congsun Li, Jiaxuan Zou, Wushi Cui, Wentao Chen, Tao Zhang, Shicheng Wang, Zizhan Su, Jian Xiao, Tao Sun, Bin Hu, Min Cheng, Zhongru Gou, Jianbin Xu, An Liu, Haobo Wu   +17 more
wiley   +1 more source

Innovative Approaches in Knee Osteoarthritis Treatment: A Comprehensive Review of Bone Marrow-Derived Products

Biomedicines
Knee osteoarthritis (OA) is a chronic articular disease characterized by the progressive degeneration of cartilage and bone tissue, leading to the appearance of subchondral cysts, osteophyte formation, and synovial inflammation.
José Fábio Lana, Joseph Purita, Madhan Jeyaraman, Bianca Freitas de Souza, Bruno Lima Rodrigues, Stephany Cares Huber, Carolina Caliari, Gabriel Silva Santos, Lucas Furtado da Fonseca, Ignacio Dallo, Annu Navani, Marco Antônio Percope De Andrade, Peter Albert Everts   +12 more
doaj   +1 more source

Biopsy needle advancement during bone marrow aspiration increases mesenchymal stem cell concentration

Frontiers in Veterinary Science, 2016
Point-of-care kits to concentrate bone marrow (BM) derived mesenchymal stem cells (MSCs) are used clinically in horses. A maximal number of MSCs per ml of marrow aspirated might be desired prior to use of a point-of-care system to concentrate MSCs.
Anne E Peters, Ashlee E Watts
doaj   +1 more source

Multifunctional Nanovaccine‐Radiotherapy Synergy Drives Anti‐Tumor Immunity via Multi‐Cascade Cell Death for Pancreatic Cancer Therapy

Advanced Science, EarlyView.
Machine‐learning‐driven transcriptomic analysis identifies FSTL3 as a key tumor‐microenvironment regulator in desmoplastic pancreatic adenocarcinoma. A cRGD‐modified liposome co‐loading gemcitabine and siFSTL3 serves as an irradiation‐triggered in situ nanovaccine. It synergizes with radiotherapy to induce ferroptosis and immunogenic cell death through
Chengyi Huang, Yushu Han, Xiang Liu, Chuanhao Wang, Xiaofei Zhu, Di Chen, Yangyang Gong, Liang Chen, Wenjuan Chen, Zhenyuan Miao, Bufu Tang, Huojun Zhang   +11 more
wiley   +1 more source