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Metabolic regulation of the bone marrow microenvironment in leukemia
Blood Reviews, 2021Most leukemia patients experience little benefit from immunotherapy, in part due to the immunosuppressive bone marrow microenvironment. Various metabolic mechanisms orchestrate the behaviors of immune cells and leukemia cells in the bone marrow microenvironment. Furthermore, leukemia cells regulate the bone marrow microenvironment through metabolism to
Yuhua Li, Rong Hu, Yirong Jiang
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The Bone Marrow Microenvironment in B-Cell Development and Malignancy
Cancers, 2022 SIMPLE SUMMARY: B cells are an essential component of the immune system and develop in the bone marrow microenvironment. B-cell development is tightly regulated by the stromal cells, fat cells and bone cells in this microenvironment. However, when B-cell
Laurence C Cheung +2 more
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Targeting the bone marrow microenvironment in acute leukemia
Leukemia and Lymphoma, 2018Despite individual differences between certain leukemias, the overall survival rate in acute leukemia remains low at approximately 40%. Novel therapeutics, including targeted therapies like tyrosine kinase inhibitors, have been incorporated into treatment regimens, but most have failed at eradicating leukemic stem cells (LSCs).
Daniela S Krause
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The Bone Marrow Microenvironment in Waldenström Macroglobulinemia
Hematology/Oncology Clinics of North America, 2018Waldenström macroglobulinemia (WM) is an indolent B-cell lymphoma defined predominantly by infiltration of lymphoplasmacytic cells into the bone marrow (BM) and increased production of monoclonal immunoglobulin M (IgM) by lymphoplasmacytic cells, and the secretion of IgM is enhanced by cytokines in the bone marrow microenvironment.
Shahrzad, Jalali, Stephen M, Ansell
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Bone marrow microenvironment in Waldenstrom's Macroglobulinemia
Best Practice & Research Clinical Haematology, 2016Waldenstrom Macroglobulinemia (WM) is a low-grade B-cell lymphoma defined firstly by infiltration of lymphoplasmacytic cells into the bone marrow (BM), the milieu where the cells acquire signals that promote malignant growth and proliferation. A second characteristic associated with WM is the increased synthesis of monoclonal immunoglobulin M (IgM) by ...
Shahrzad, Jalali, Stephen M, Ansell
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Bone marrow microenvironment of MPN cells
2021In this chapter, we will discuss the current knowledge concerning the alterations of the cellular components in the bone marrow niche in Myeloproliferative Neoplasms (MPNs), highlighting the central role of the megakaryocytes in MPN progression, and the extracellular matrix components characterizing the fibrotic bone marrow.
Malara A. +3 more
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Targeting the Bone Marrow Microenvironment
2016Unprecedented advances in multiple myeloma (MM) therapy during the last 15 years are predominantly based on our increasing understanding of the pathophysiologic role of the bone marrow (BM) microenvironment. Indeed, new treatment paradigms, which incorporate thalidomide, immunomodulatory drugs (IMiDs), and proteasome inhibitors, target the tumor cell ...
Michele, Moschetta +2 more
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Metastasis in the Bone Marrow Microenvironment
2004Although metastatic growth of non-skeletal cancer in bone as an organ is commonly referred to as bone metastasis, any metastasis to bone is in fact a metastasis to the bone marrow. The extensive changes induced by cancer metastasis in bone (either lytic, or more rarely, sclerotic) represent secondary changes induced to fulfill the need of cancer cells ...
BIANCO, Paolo +2 more
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Bone Marrow Microenvironment and the Progression of Multiple Myeloma
Leukemia & Lymphoma, 1992The BM microenvironment in MM, in terms of adhesive features, is well organized to entrap circulating precursors with BM-seeking properties and is able to produce cytokines that offer them the optimal conditions for local growth and final differentiation.
Caligaris Cappio F +6 more
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Exosomes in the Healthy and Malignant Bone Marrow Microenvironment
2021The bone marrow (BM) is a complex organ that sustains hematopoiesis via mechanisms involving the microenvironment. The microenvironment includes several cell types, neurotransmitters from innervated fibers, growth factors, extracellular matrix proteins, and extracellular vesicles.
Caitlyn A, Moore +5 more
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