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The Lymphopoietic Microenvironment in Bone Marrow
1990Publisher Summary Various components of the lymphopoietic microenvironment can be grown in culture, where they can be dissected, characterized, and independently manipulated. Dexter cultures favor survival of multipotential stem cells and active production of granulocytes and macrophages.
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Targeting the bone marrow microenvironment in hematologic malignancies
Seminars in Hematology, 2004Unicellular drug-resistant models have been critical in elucidating intrinsic drug-resistant mechanisms; however, these models do not consider resistance mechanisms that may be elicited by extrinsic influences such as the tumor microenvironment. We propose that specific niches within the tumor microenvironment may provide a sanctuary for subpopulations
William S, Dalton +4 more
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The bone marrow microenvironment in health and disease at a glance
Journal of Cell Science, 2018ABSTRACT The bone marrow microenvironment (BMM) is the ‘domicile’ of hematopoietic stem cells, as well as of malignant processes that can develop there. Multiple and complex interactions with the BMM influence hematopoietic stem cell (HSC) physiology, but also the pathophysiology of hematological malignancies. Reciprocally, hematological
Rahul Kumar +2 more
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Targeting the bone marrow microenvironment in multiple myeloma
Immunological Reviews, 2014SummaryMultiple myeloma (MM) is characterized by clonal expansion of malignant plasma cells in the bone marrow (BM). Despite the significant advances in treatment, MM is still a fatal malignancy. This is mainly due to the supportive role of the BM microenvironment in differentiation, migration, proliferation, survival, and drug resistance of the ...
Yawara, Kawano +7 more
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Androgen, Estrogen, and the Bone Marrow Microenvironment
2006Abstract : In this project we plan to analyze androgen- and estrogen-responsive gene expression in the bone marrow. We plan to work to: determine if castration-induced gene expression changes in mouse bone marrow are caused by the deficiency of testosterone or estrogen; analyze androgen and estrogen-sensitive cytokine and gene expression changes in ...
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Simulation of the bone marrow microenvironment
2013HSPC maintenance, phenotype, viability and functionality in this system were Hematopoietic stem and progenitor cells (HSPCs) are of immense significance, not only due to their use in traditional allogenic transplantation therapy, but also as a paradigm for adult stem cells capable of self-renewal as well as multi-potent differentiation.
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Leukemia and bone marrow microenvironment
STEM CELLS, 1994S C, Gulati, B, Nath
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Blood–Bone Axis and Bone Marrow Microenvironment
2009The function of the bone marrow is to coordinate hematopoiesis, i.e., the continuous production of mature blood cells throughout life. Hematopoiesis often is envisioned as a pyramidal/hierarchical process with the least differentiated cells, i.e., those of greatest maturation potential at the top, hierarchically speaking, and cells that have undergone ...
Aaron M. Havens +2 more
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The Bone Marrow Microenvironment for Hematopoietic Stem Cells
2017The main function of the microenvironment in the bone marrow (BM) is to provide signals that regulate and support the production of the billions of blood cells necessary to maintain homeostasis. The best characterized BM microenvironment is the niche that regulates hematopoietic stem cells.
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Bone marrow microenvironment in prostate cancer
Nature Reviews Urology, 2021openaire +2 more sources