Results 131 to 140 of about 183,117 (350)

Bone formation and resorption markers as diagnostic tools for bone metastases evaluation

The International Journal of Biological Markers, 2012
Bone metastases are a frequent complication of several types of cancers. Since bone metastases are difficult to diagnose with the current available approaches, there is a demand for new methods for assessing bone response.
Emanuela Galliera PhD, Alessandro Luzzati, Giuseppe Perrucchini, Fabio Gagliano, Ludovica Colloredo Mels, Giuseppe Banfi, Massimiliano Marco Corsi Romanelli, Lorenzo Drago   +7 more
doaj   +1 more source

Androgen Receptor‐Induced Lactoferrin Accelerates Prostate Tumorigenesis Through Modulating Ferroptosis

Advanced Science, EarlyView.
This study demonstrates that transcription factor androgen receptor (AR) directly binds the LF promoter, driving lactoferrin overexpression to promote ferritin (FTH1/FTL) upregulation and inhibit p53‐ALOX12‐mediated ferroptosis in prostate cancer. Lactoferrin could be a new potential therapeutic target in prostate cancer.
Can Liu, Qiu Peng, Xiaoyue Zhang, Zhengshuo Li, Yangge Wu, Yuqing Wen, Run Zheng, Shuanglong Wu, Chenfei Zhou, Zhengyu Hu, Lanjun Shu, Xinyi Ma, Qiuyang Li, Ya Ma, Chunlin Ou, Ming Zhao, Songqing Fan, Lingyu Wei, Jian Ma   +18 more
wiley   +1 more source

Solid tumours show osteotropism: Mechanisms of bone metastases

, 2013
Bone metastases are a dismal consequence of cancer, causing severe morbidity and reducing the quality of life of patients. Solid tumours such as breast, prostate, lung and kidney cancer showed a marked osteotropism dependent on the special ...
FERRACINI, RICCARDO, Roato, Ilaria
core   +1 more source

Supplementary Figure S6 from Targeted Therapy to β3 Integrin Reduces Chemoresistance in Breast Cancer Bone Metastases

, 2023
Gregory C. Fox, Xinming Su, Jennifer L. Davis, Yalin Xu, Kristin A. Kwakwa, Michael H. Ross, Francesca Fontana, Jingyu Xiang, Alison K. Esser, Elizabeth Cordell, Kristen Pagliai, Ha X. Dang, Jothilingam Sivapackiam, Sheila A. Stewart, Christopher A. Maher, Suzanne J. Bakewell, James A. J. Fitzpatrick, Vijay K. Sharma, Samuel Achilefu, Deborah J. Veis, Gregory M. Lanza, Katherine N. Weilbaecher   +21 more
openalex   +1 more source

TSPYL5 Promotes Triple‐Negative Breast Cancer Metastasis by Antagonizing USP10‐Mediated PTEN Stabilization to Unleash a ZEB1‐Dependent EMT Program

Advanced Science, EarlyView.
The hyperactivation of PI3K/AKT signaling in PTEN wild‐type triple‐negative breast cancer represents a clinical paradox. We delineate a novel post‐translational regulatory axis wherein the oncogene TSPYL5 competitively antagonizes the deubiquitinase USP10.
Jiaying Shi, Ming Yi, Shengyu Xie, Zhaokun Wang, Xinyue Zhang, Yangwei Zhang, Rui Tang, Yuan Yang, Yunqiang Liu   +8 more
wiley   +1 more source

Prognostic factors and real-life applicability of prognostic models for patients with bone metastases of carcinoma

Objective: This study aimed to investigate the factors affecting the survival of patients with bone carcinoma metastases and assess the clinical applicability of existing prognostic models.
Akif Mirioglu, Melih Bagir, Bugra Kundakci, Kaan Ali Dalkir, Mehmet Ali Deveci, Hilmi Serdar Ozbarlas   +5 more
core   +1 more source

Supplementary Data from A Phase I Study of Combination Olaparib and Radium-223 in Men with Metastatic Castration-Resistant Prostate Cancer (mCRPC) with Bone Metastases (COMRADE)

, 2023
Elizabeth Pan, Wanling Xie, Archana Ajmera, Arlene Araneta, Christina Jamieson, Edmund Folefac, Arif Hussain, Christos E. Kyriakopoulos, Adam C. Olson, Mamta Parikh, Rahul Atul Parikh, Biren Saraiya, S. Percy Ivy, Eliezer M. Van Allen, Neal I. Lindeman, Bose Kochupurakkal, Geoffrey I. Shapiro, Rana R. McKay   +17 more
openalex   +1 more source

Impact of different visceral metastatic sites on survival in metastatic prostate cancer patients.

PLoS ONE
IntroductionVisceral metastasis is an important predictor for poor outcomes in prostate cancer, however, the prognostic significance surrounding the specific sites of visceral metastasis remains unclear.
Gu-Shun Lai, Chuan-Shu Chen, Jason Chia-Hsien Cheng, Jian-Ri Li, Cheng-Kuang Yang, Chia-Yen Lin, Sheng-Chun Hung, Kun-Yuan Chiu, Shian-Shiang Wang   +8 more
doaj   +1 more source

Macrophage Extracellular Traps in Immunity and Cancer

Advanced Science, EarlyView.
As a macrophage‐mediated innate defense mechanism, the dysregulated release of METs drives chronic inflammation and influences tumor progression. Furthermore, METs exhibit a functional duality within the tumor microenvironment, capable of both promoting and suppressing tumor development.
Junyao Li, Eugenie Nepovimova, Adam Grundel, Lukas Peter, Qinghua Wu, Kamil Kuca   +5 more
wiley   +1 more source

Bone cancer : primary bone cancers and bone metastases /

"Elsevier science & technology books."Includes bibliographical references and index.Epidemiology of primary bone tumors and economical aspects of bone metastases -- Tumor: bone interactions: there is no place like bone -- Stem cell niches in the bone ...
Heymann, Dominique,editor.
core