Results 121 to 130 of about 183,117 (350)

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Bone-targeted agent treatment patterns and the impact of bone metastases on patients with advanced breast cancer in the United States

, 2019
Objective: Bone metastases are common among patients with advanced breast cancer, putting patients at increased risk of skeletal-related events (SREs).
Francesca Gatta (6086999), David Henry (27846), Yi Qian (466487), Alex Rider (6086993), Jean-Jacques Body (1883), Jonathan De Courcy (6086996), Roger von Moos (103705), Guy Hechmati (5616326), Debajyoti Bhowmik (5116094)   +8 more
core   +1 more source

AR Expression in Breast Cancer CTCs Associates with Bone Metastases [PDF]

, 2018
Nicola Aceto, Aditya Bardia, Ben S. Wittner, Maria Donaldson Collier, Ryan OʼKeefe, Amanda Engstrom, Francesca Bersani, Yu Zheng, Valentine Comaills, Kira Niederhoffer, Huili Zhu, Olivia Mackenzie, Toshi Shioda, Dennis C. Sgroi, Ravi Kapur, David T. Ting, Beverly Moy, Sridhar Ramaswamy, Mehmet Toner, Daniel A. Haber, Shyamala Maheswaran   +20 more
openalex   +1 more source

Review of: "Personalized (tailored) treatment with antiresorptive drugs (bisphosphonates, denosumab) in patients with bone metastases from solid tumors – A “Pico” document by Rete Oncologica Piemonte-Valle D’Aosta Bone Metastatic Disease Study Group" [PDF]

, 2023
Stefano Sganga
openalex   +1 more source

Incidence and radiotherapy treatment patterns of complicated bone metastases

Journal of Bone Oncology
Background: Despite the encouraging results of the SCORAD trial, single fraction radiotherapy (SFRT) remains underused for patients with complicated bone metastases with rates as low as 18–39%. We aimed to evaluate the incidence and treatment patterns of
Cedric Peters, Julie Vandewiele, Yolande Lievens, Marc van Eijkeren, Valérie Fonteyne, Tom Boterberg, Pieter Deseyne, Liv Veldeman, Wilfried De Neve, Chris Monten, Sabine Braems, Fréderic Duprez, Katrien Vandecasteele, Piet Ost   +13 more
doaj   +1 more source

Polymer Matrix‐Based 3D Culture Significantly Enhances the Differentiation and Immunomodulatory Functions of Human Adipose‐Derived Stem Cells

Advanced Science, EarlyView.
The 3D culture of human adipose‐derived stem cells (hADSCs) on a crosslinked cyclosiloxane‐based poly‐Z matrix platform enables the formation of spheroid structures enriched with extracellular matrix (ECM). These ECM‐enriched hADSC spheroids cultured on poly‐Z exhibit enhanced differentiation potential, immunomodulatory capacity, and in vivo ...
Changjin Seo, Dohyeon Kim, Junhyuk Song, Sun‐Young Kim, Youngju Son, Afia Tasnim Rahman, Sangyong Jon   +6 more
wiley   +1 more source

A multidisciplinary bone metastases clinic at Toronto Sunnybrook Regional Cancer Centre – A review of the experience from 1999 to 2005

, 2008
Kathy K Li, Emily Sinclair, Joan Pope, Macey Farhadian, Kristin Harris, Julie Napolskikh, Albert Yee, Lawrence Librach, Lesia Wynnychuk, Cyril Danjoux, Edward Chow.
Kathy K Li, Emily Sinclair, Joan Pope, Macey Farhadian, et al, Kristin Harris   +5 more
core  

Textbook of bone metastases

, 2005
The epidemiological and clinical importance of bone metastases has long been recognised. For example, the incidence of bone metastases in breast and prostate cancers is 70%, whereas it is only 30 to 40% in metastatic lung cancer.
Coleman, Robert E., Saillant, Gérard, Capanna, Rodolfo, Coia, Lawrence R., Jasmin, Claude   +4 more
core   +1 more source

Tetrastigma Hemsleyanum Polysaccharide Suppresses Triple‐Negative Breast Cancer by Disrupting the Hippo‐YAP/TEAD4‐PDIA4 Axis and Endoplasmic Reticulum Stress Adaptation

Advanced Science, EarlyView.
ABSTRACT Triple‐negative breast cancer (TNBC) exhibits addiction to chronic endoplasmic reticulum (ER) stress, which sustains an aggressive metastatic phenotype through activation of the unfolded protein response (UPR). Here, we identify a previously unrecognized “ER‐stress addiction” axis in which the Hippo pathway effector TEAD4 directly ...
Yini Shang, Wentao Si, Youxue Zhang, Jialin Liu, Huaixi Zhang, Yafei Li, Hongmeng Su, Wei Jiang, Zhishan Ding, Lihong Wang   +9 more
wiley   +1 more source

Surgical treatment for pelvic bone metastases.

, 2012
The pelvis is the second most common site of bone metastases after the spine. Pain, bone destruction causing mechanical instability and pathological fractures are the most common manifestations.
Bianchi G, Brunocilla E, Fabbri N, RUGGIERI, PIETRO, Mavrogenis AF, BRUNOCILLA, EUGENIO   +5 more
core   +1 more source