Results 151 to 160 of about 183,117 (350)

Sclerotic bone metastases

, 2015
Varun Babu
openalex   +1 more source

Extracellular Vesicle‐Transferred ATP‐Citrate Lyase Induces Monocyte Differentiation Toward Tumor‐Associated Macrophages and Fuels Hepatocellular Carcinoma Progression

Advanced Science, EarlyView.
Hepatocellular carcinoma (HCC)‐derived extracellular vesicles (EVs) enrich the metabolic enzyme ATP‐citrate lyase (ACLY). EV‐transferred ACLY enhances palmitate biosynthesis, increases the S‐palmitoylation and stability of multiple immune checkpoint proteins, augments the cellular immunosuppressive activity, and ultimately accelerates the malignant ...
Zhijun Liu, Haihong Lai, Qing Yang, Chaoyue Zhang, Bin Jia, Qiyi Chen, Yuling Deng, Fen Cao, Yuyu You, Zhe Li, Dongming Kuang, Bo Li   +11 more
wiley   +1 more source

Association of genotype with bone metabolism, skeletal adaptation and stress fracture injury occurrence

, 2014
Positive changes in bone metabolism, structural characteristics, size and mass are commonly associated with weight-bearing exercise. Despite this, negative effects of exercise on bone phenotypes, such as stress fracture injuries have been reported ...
Varley, I
core  

Loss of inhibition over master pathways of bone mass regulation results in osteosclerotic bone metastases in prostate cancer [PDF]

, 2009
Prostate cancer is the most common cancer among men in industrialised countries. Most patients with prostate cancer, however, will not die of it. As a result, many of them will experience symptomatic metastasis during the course of the disease.
Cecchini, Marco Giovanni, Rentsch, Cyrill Achim, Thalmann, George   +2 more
core  

Measurement of growth rate of lung metastases in 21 patients with bone or soft-tissue sarcoma [PDF]

, 1993
Carl Blomqvist, Tom Wiklund, Maija Tarkkanen, Inkeri Elomaa, Martti Virolainen   +4 more
openalex   +1 more source

Single‐Cell Dissection of Tumor‐Infiltrating Lymphocytes Reveals Cellular Architecture Predictive of Therapeutic Efficacy in Acral Melanoma

Advanced Science, EarlyView.
Autologous tumor‐infiltrating lymphocyte (TIL) therapy shows promising efficacy in acral melanoma, yet determinants of durable response remain unclear. By integrating single‐cell transcriptomics and TCR sequencing, this study reveals that TIL products enriched for T follicular helper and intermediate exhausted T cells establish persistent clonal ...
Chao Zhang, Wanyi Xiao, Hongru Shen, Fenge Li, Ting Li, Weihong Zhang, Haotian Liu, Ziwei Gao, Hongyu Wang, Xiubao Ren, Kexin Chen, Xiangchun Li, Jilong Yang   +12 more
wiley   +1 more source

The cntribution of nuclear medicine in the diagnosis of bone metastases

, 2009
Nuclear medicine plays a relevant role in the diagnosis and therapy of bone metastases. Imaging of the bone has been one of the first nuclear medicine techniques applied in humans and still is one of the major requests from physicians.
SIGNORE, Alberto, RAJO Dierckx, Dierckx, Rudi, Alberto Signore, Marnix Lam, Glaudemans, Andor W.J.M., Niels Veltman, Lam, Marnix G. E. H., Rudi Dierckx, MGEH Lam, NC Veltman, AWJM Glaudemans, Veltman, Niels C., Glaudemans, Andor W.J.M.; id_orcid, Andor Glaudemans   +14 more
core   +1 more source

Tumor‐Derived Exosomes Deliver Membrane‐Bound Fgl2 to Activate FcγRIIB‐Mediated Immunosuppression in Myeloid‐Derived Suppressor Cells

Advanced Science, EarlyView.
This study reveals that the Fgl2‐FcγRIIB signaling axis is a key mechanism by which MDSCs mediate tumor immune evasion. Tumor‐derived exosomes systemically activate MDSCs via this pathway, positioning this axis as a promising broad‐spectrum target for cancer immunotherapy.
Fenglin Lin, Dingqin Cai, Chunli Jian, Yaxian Qi, Linpeng Zheng, Qiao Yang, Longyao Zhang, Diangang Chen, Lingchen Li, Ping Cai, Lingyou Sun, Luping Zhang, Jianguo Sun   +12 more
wiley   +1 more source

Detection of Bone Metastases and Evaluation of Therapy Response in Prostate Cancer Patients by Radiolabelled Choline PET/CT

, 2016
Bone is the most common site for metastases in human prostate cancer patients. Skeletal metastases are a significant cause of morbidity and mortality and overall greatly affect the quality of life of patients.
Mapelli P., Incerti E., Picchio M., Paola Mapelli, Elena Incerti, Maria Picchio   +5 more
core   +1 more source

Aptamer‐Engineered Liposomal Platform Enables in Situ cDC1 Vaccination to Potentiate Immunotherapy in Prostate Cancer

Advanced Science, EarlyView.
Prostate cancer is immunologically ‘cold’, with scarce, dysfunctional type 1 conventional dendritic cells (cDC1s) that limit T cell priming. We introduce an aptamer‐targeted liposomedelivering FMS‐like tyrosine kinase 3 ligand (Flt3L) and chlorin e6 (Ce6). Ultrasound induces antigen release and cDC1s recruitment, creating an in situ cDC1 vaccine.
Jiayi Wang, Xuan Wang, Xinfeng Dai, Linxin Tian, Wencheng Shen, Xueliang Liu, Wei Xue, Jiahua Pan, Yu Yang   +8 more
wiley   +1 more source