Results 161 to 170 of about 241,339 (286)

Microenvironmental and Molecular Pathways Driving Dormancy Escape in Bone Metastases. [PDF]

Int J Mol Sci
Bakir M, Dabaliz A, Dawalibi A, Mohammad KS.   +3 more
europepmc   +1 more source

Macrophage Extracellular Traps in Immunity and Cancer

Advanced Science, EarlyView.
As a macrophage‐mediated innate defense mechanism, the dysregulated release of METs drives chronic inflammation and influences tumor progression. Furthermore, METs exhibit a functional duality within the tumor microenvironment, capable of both promoting and suppressing tumor development.
Junyao Li, Eugenie Nepovimova, Adam Grundel, Lukas Peter, Qinghua Wu, Kamil Kuca   +5 more
wiley   +1 more source

Bone metastases from endocrine cancer: advances in diagnosis, treatment, and prevention. [PDF]

Front Endocrinol (Lausanne)
Huang S, Shen Y, Li H, Geng T, Yan J, Wang L, Sui L.   +6 more
europepmc   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Prospective Evaluation of Stereotactic Body Radiation Therapy for Reirradiation of Bone Metastases. [PDF]

Adv Radiat Oncol
Hammoudeh L, Shin KY, Hertan L, Krishnan M, Spektor A, Huynh MA, Fisher C, Balboni T.   +7 more
europepmc   +1 more source

An Implantable Scaffold Sequentially Releasing STING Agonist and B7‐H3 Antibody for Bone Metastasis Immunotherapy

Advanced Science, EarlyView.
We developed an implantable dual‐drug depot using GelMA for bone metastasis treatment, co‐delivering MSA‐2 and αB7‐H3‐loaded CaCO3 microparticles. Sustained release from GelMA scaffold enables MSA‐2 to activate STING signaling and enhance T‐cell infiltration and activation, while sequentially released αB7‐H3 blocks MSA‐2‐induced B7‐H3 upregulation ...
Qijun Lin, Hong Xiao, Shuai Fan, Kaimin Cai, Yanteng Xu, Xinwen Wang, Guanhong Chen, Chuandong Lang, Xinsheng Peng, Mingqiang Li, Yuhu Dai   +10 more
wiley   +1 more source

Denosumab Plus Immune Checkpoint Inhibitors in Bone Metastases From Solid Tumors. [PDF]

Cancer Control
Wang N, Song F, Li X, Chen H.
europepmc   +1 more source

Combined ablation and radiation therapy of spinal metastases: A novel multimodality treatment approach [PDF]

, 2015
Friedman, Michael V, Greenwood, Taylor J, Hillen, Travis J, Jennings, Jack W, Robinson, Clifford G, Wallace, Adam   +5 more
core   +1 more source

The ITGB2‐COPS3‐SOX2 Axis and SOX2 Liquid‐Liquid Phase Separation: Dual Mechanisms Governing Osteosarcoma Stemness

Advanced Science, EarlyView.
Osteosarcoma stemness is driven by the ITGB2‐COPS3‐SOX2 signaling axis. This study reveals that nuclear COPS3 stabilizes SOX2, which in turn undergoes liquid‐liquid phase separation to promote stemness. Based on this mechanism, a novel COPS3 inhibitor, Z‐5891, was developed, effectively suppressing tumor growth and stemness in vivo, offering a ...
Lei Guo, Zhiqing Zhao, Wei Wang, Jianfang Niu, Bing Wang, Yunfei Lin, Wei Guo, Taiqiang Yan   +7 more
wiley   +1 more source

Influence of concomitant distant lymph node metastases in metastatic hormone-sensitive prostate cancer patients with bone metastases. [PDF]

World J Urol
Wenzel M, Lauer B, Mühlthaler VG, Filzmayer M, Siech C, Le C, Humke C, Kosiba M, Kriegmair M, Steuber T, Chun FKH, Mandel P.   +11 more
europepmc   +1 more source