Results 161 to 170 of about 2,076,755 (337)

Bone density and pain response following intensity-modulated radiotherapy versus three-dimensional conformal radiotherapy for vertebral metastases - secondary results of a randomized trial [PDF]

, 2018
Tanja Sprave, Vivek Verma, Robert Förster, Ingmar Schlampp, Katharina Hees, Thomas Brückner, Tilman Bostel, Rami A. El Shafie, Thomas Welzel, Nils H. Nicolay, Jürgen Debus, Harald Rief   +11 more
openalex   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Samarium-153-ethylene diamine tetramethylene phosphonate, a beta-emitting bone-targeted radiopharmaceutical, useful for patients with osteoblastic bone metastases

Cancer Management and Research, 2013
John Longo,1 Stephen Lutz,2 Candice Johnstone1 1Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI, USA; 2Department of Radiation Oncology, Blanchard Valley Regional Cancer Center, Findlay, OH, USA Abstract: Bone metastases are
Longo J, Lutz S, Johnstone C
doaj  

Alkaline Phosphatase‐Activated NIR‐II AIEgens Nanosystem for Surgical and Postoperative Closed‐Loop Therapy of Advanced Osteosarcoma

Advanced Science, EarlyView.
This study designed a tumor microenvironment‐responsive AIEgen nanoparticle for near‐infrared photoimmunotherapy, which inhibits primary tumors and metastasis by promoting pyroptosis and suppressing aerobic glycolysis. ABSTRACT In advanced osteosarcoma, tumor invasion often prevents complete resection, and immunotherapy is limited by the tumor's ...
Kaiyuan Liu, Ruotong Li, Li Zhang, Hengli Lu, Binhui Yang, Qian Hu, Yining Tao, Haoran Mu, Jing Han, Pengfei Zan, Jiakang Shen, Dongqing Zuo, Hongsheng Wang, Wei Sun, Xingjun Zhu   +14 more
wiley   +1 more source

Core Fucosylation Represses SMURF1‐Dependent Degradation of CD47 to Promote Tumor Immune Evasion

Advanced Science, EarlyView.
FUT8‐mediated core fucosylation of CD47 at N111 blocks SMURF1 binding and reduces CD47 ubiquitination and degradation. Blocking N111 glycosylation reduces CD47 expression and promotes macrophage phagocytosis of tumor cells. Furthermore, ablating CD47 core fucosylation boosts CD103+ dendritic cells (DCs) infiltration, increases natural killer (NK) cell ...
Yuting Cao, Siyuan Chai, Mingyang Li, Xiaoming Chen, Jiating Hu, Bingyi Lin, Liming Wu, Wen Yi, Qiang Zhu   +8 more
wiley   +1 more source

Cancer Response Criteria and Bone Metastases: RECIST 1.1, MDA and PERCIST

Journal of Cancer, 2010
Response criteria represent the standard by which the efficacy of therapeutic agents is determined in cancer trials. The most widely used criteria are based on the anatomic measurement of solid tumors.
Colleen M. Costelloe, Hubert H. Chuang, John E. Madewell, Naoto T. Ueno
doaj  

Pain response of patients treated with radiotherapy for painful bone metastases between 2013 and 2024 – An analysis of the prospective real-world PRESENT cohort [PDF]

Renée Hovenier, Eline H. Huele, Bas J. J. Bindels, Anouk van Oss, R. H. Kuijten, Jorrit‐Jan Verlaan, N. Kasperts, Wietse S.C. Eppinga, Yvette M. van der Linden, H.M. Verkooijen, Roxanne Gal, Joanne M. van der Velden   +11 more
openalex   +1 more source

Electrochemotherapy Is Effective in the Treatment of Bone Metastases [PDF]

, 2022
L Campanacci, Luca Cevolani, Francesca de Terlizzi, Laura Sáenz, Nikolin Alì, Giuseppe Bianchi, Davide María Donati   +6 more
openalex   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Bone Metastases in Neuroendocrine Neoplasms: From Pathogenesis to Clinical Management [PDF]

, 2019
Barbara Altieri, Carla Di Dato, Chiara Martini, Concetta Sciammarella, Antonella Di Sarno, Annamaria Colao, Antongiulio Faggiano   +6 more
openalex   +1 more source