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Bone-Targeted Nanoplatform Combining Zoledronate and Photothermal Therapy To Treat Breast Cancer Bone Metastasis

open access: yesACS Nano, 2019
Bone metastasis, a clinical complication of patients with advanced breast cancer, seriously reduces the quality of life. To avoid destruction of the bone matrix, current treatments focus on inhibiting the cancer cell growth and the osteoclast activity ...
Kun Ge, Yu Han, Haisong Zhang
exaly   +2 more sources
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Bone metastasis and rehabilitation

Cancer, 2001
Patients with cancer that has metastasized to bone will frequently develop functional problems that may respond to rehabilitative treatment. Many rehabilitation professionals, however, are concerned about the possibility of producing pathologic fracture with their treatment.
R W, Bunting, B, Shea
openaire   +2 more sources

MicroRNAs in Bone Metastasis

Current Osteoporosis Reports, 2019
This review provides an update on the recent literature describing the role of microRNAs (miRNAs) in cancer formation and bone metastasis. We confined our focus on osteosarcoma, breast cancer, prostate cancer, and epithelial-mesenchymal transition.In all areas covered, major discoveries on the role of miRNAs in tumorigenesis and metastasis have been ...
Eric, Hesse, Hanna, Taipaleenmäki
openaire   +2 more sources

Metastasis in the nasal bones

Journal of the Faculty of Radiologists, 1958
Summary A case of metastasis from mammary carcinoma in the nasal bones is described. There had been previous injury to the site. Photographs and radiographs are shown.
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Bone resorption and bone metastasis risk

Medical Hypotheses, 2018
Breast cancer tumors have a tendency to metastasize to the bone. After development of a bone metastasis, the median survival time is 40 months. Currently, little is known about the modifiable risk factors for developing bone metastases in women diagnosed with breast cancer. One possible modifiable risk factor is increased bone resorption.
Katlynn M, Mathis   +5 more
openaire   +2 more sources

Mechanisms of Tumor Metastasis to Bone

Critical Reviews in Eukaryotic Gene Expression, 2000
Bone metastases occur in approximately 80% of patients with advanced cancer. They are characterized by cancer cell growth and bone destruction that cause pain, fractures, anemia, and hypercalcemia. At diagnosis, bone metastases are usually incurable owing to their advanced development.
Weber, M.   +6 more
openaire   +3 more sources

Mechanisms of bone metastasis

Cancer, 1997
Solid cancers metastasize to bone by a multistep process that involves interactions between tumor cells and normal host cells. Some tumors, most notably breast and prostate carcinomas, grow avidly in bone because the bone microenvironment provides a favorable soil.
openaire   +2 more sources

Mechanisms of Bone Metastasis

New England Journal of Medicine, 2004
Extract: Cancer frequently spreads to bone, a process termed bone metastasis. Up to 70% of patients with breast cancer or prostate cancer, and 15 to 30% of patients with lung, colon, bladder or kidney cancer develop bone metastasis. Once tumors go to bone, such as in patients with breast cancer or prostate cancer, they are incurable, and only 20% of ...
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Activin A and bone metastasis

Journal of Cellular Physiology, 2010
AbstractActivin A, is a multifunctional cytokine of the transforming growth factor‐β superfamily of growth factors. This molecule has been shown to be implicated in the regulation of a broad range of important biological functions including bone remodelling.
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Hepatoma Metastasis to Bone

JAMA: The Journal of the American Medical Association, 1971
To the Editor.— Suffett et al ( 215 :120, 1971) in reference to an article by Reichbach et al 1 on osseous metastases of hepatoma reported a tumor that had metastasized to a rib. They suggest that osseous metastases from hepatomas are very uncommon. This is not really the case, as various authors 2-5 have reported an incidence ranging from 1.6% to 12%
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