Results 61 to 70 of about 53,845 (250)

Lesion Site‐Targeted Microspheres Modulate Nav1.7‐Related Signaling for Osteoarthritis Treatment

Advanced Science, EarlyView.
Cartilage‐targeted carbamazepine‐loaded WYRGRL‐modified composite microspheres (CBZ/WCOM) anchor to exposed type II collagen in osteoarthritic lesions and release carbamazepine under acidic conditions. This bind‐then‐release platform modulates Nav1.7‐related sodium signaling, Na⁺/Ca²⁺ exchanger‐associated Ca2+ dynamics, and heat shock protein 70 ...
Cheng Chen, Jiaying Li, Jinjin Ma, Xiaonan Yuan, Yao Xiao, Yang Zhang, Yuan Chen, Hao Jiang, Hui He, Jie Hu, Qianglong Chen, Jinniu Zhang, Bin Li, Yun Zhou, Fengxuan Han, Yong Wang   +15 more
wiley   +1 more source

Biodegradable Zn‐Based Implants: Progress, Challenges, and Pathways toward Clinical Translation

Advanced Science, EarlyView.
Exploring biodegradable Zn‐based implants offers a promising pathway to next‐generation biomedical devices with balanced degradation and biocompatibility. A comprehensive overview of biodegradable Zn‐based implants, covering their biological significance, material design principles, and advanced engineering strategies is provided.
Panfeng Zhao, Zhengquan Wang, Hui Yang, Xiyuan Zhang, Hanyuan Liu, Xiaotong Lu, Xiaocheng Li, Yanyan Liu, Xi Zhao, Wenhao Zhou, Yufeng Zheng   +10 more
wiley   +1 more source

Bone mineral density (BMD) in rats in a model of metabolic syndrome (metS)

Journal of Nutrition & Intermediary Metabolism, 2014
Background/Aims: Studies assessing association between MetS and bone status have yielded inconsistent results; subjects with MetS had lower bone mineral density (BMD) but also lower fracture risk. We investigated BMD in an animal model of MetS and the effects of feeding a variety of different nutraceuticals.
L.C. Ward, S.K. Panchal, M. Bhaswant, W.-Y. Wong, H. Poudyal, L. Brown   +5 more
openaire   +2 more sources

Genetic prediction of blood cell reactivity and its potential causal influence on bone continuity and density disorders

Animal Models and Experimental Medicine, EarlyView.
We applied Mendelian randomization to explore causal links between blood cell traits and skeletal disorders. Using genetic instruments from large‐scale summary statistics, we assessed effects on bone continuity, density, and structural integrity. Sensitivity and reverse analyses confirmed robust associations, highlighting potential shared biological ...
Zhiqin Deng, Zhe Zhao, Wenting Jiang, Xiaoqiang Chen, Jianquan Liu, Xu Tao, Zhengyang Lin, Zhenhan Deng, Wencui Li   +8 more
wiley   +1 more source

The Relationship Between Knee Osteoarthritis and Osteoporosis in Postmenopausal Women

Türk Osteoporoz Dergisi, 2002
In this study the bone density of the upper femur and radius were compared accoding to the severity of knee osteoarthritis (OA), bone mineral index (BMI) and age.
S. Karakaşlı, H. Uğurlu, O. Tüfekçi, F. Levendoğlu   +3 more
doaj  

Anti‐inflammatory and osteogenic effects of transcutaneous electrical nerve stimulation in knee osteoarthritis rats via the regulation of the intestinal microbiota

Animal Models and Experimental Medicine, EarlyView.
Transcutaneous electrical nerve stimulation (TENS) improved knee osteoarthritis (KOA) in rats by regulating interleukin‐1β (IL‐1β), IL‐6, and IL‐8 expressions and the bone morphogenetic protein 2 (BMP‐2)/transforming growth factor β (TGF‐β) signaling pathway.
Yan Sun, Tong Ma, Ran Chen, Lan Shen, Xun Tang, Zhiqiang Shen, Hongbin Zhao   +6 more
wiley   +1 more source

Bone Mineral Density in Chronic Liver Disease Patients: High Prevalence of Osteopenia and Osteoporosis in Patients of Advanced Cirrhosis

APIK Journal of Internal Medicine
Background: Hepatic osteodystrophy is a well-known metabolic bone complication in individuals with chronic liver disease (CLD). The pathophysiology is unknown, and evidence of increased risk of osteoporosis and osteopenia in CLD is inconsistent ...
Rakesh Kumar Koul, Anees Ahmad Nengroo, Nisar Ahmad Shah, Shagufta Parveen, Sabhiya Majeed, Qudsia Fatima   +5 more
doaj   +1 more source

The influence of lifestyle, menstrual function and oral contraceptive use on bone mass and size in female military cadets

Nutrition & Metabolism, 2007
Purpose To determine the influence of menstrual irregularity, oral contraceptive use and other factors on bone mineral density (BMD) and bone size at different skeletal sites in 135 college-aged fit women.
Tendy Susan, Zion Marsha, Nieves Jeri W, Ruffing Jamie A, Garrett Patricia, Lindsay Robert, Cosman Felicia   +6 more
doaj   +1 more source

UHPLC–MS based metabolomics study of the ErZhi formula on skeletal muscle against osteosarcopenia focusing on energy metabolism

Animal Models and Experimental Medicine, EarlyView.
ErZhi formula (EZF) is composed of Ligustri Lucidi Fructus (LLF) and Ecliptae herba (EH). Ovariectomized (OVX) and sham rats received 12‐week intragastric treatment with EZF, alendronate, and vehicle saline. Gastrocnemius tissues were harvested to systematically evaluate pharmacodynamic changes in skeletal muscle morphology, mitochondrial ...
Yuqing Pang, Ningning Li, Yujie Ding, Shuzhen Hou, Jing Liu, Xiuxue Liu, Erwei Liu, Xiaopeng Chen   +7 more
wiley   +1 more source

Determinants of bone mass and bone size in a large cohort of physically active young adult men

Nutrition & Metabolism, 2006
The determinants of bone mineral density (BMD) at multiple sites were examined in a fit college population. Subjects were 755 males (mean age = 18.7 years) entering the United States Military Academy. A questionnaire assessed exercise frequency and milk,
Garrett P, Tendy Susan, Zion M, Cosman F, Ruffing JA, Lindsay R, Nieves JW   +6 more
doaj   +1 more source