Results 61 to 70 of about 4,065,576 (293)

TNAP and PHOSPHO1 Function Synergistically to Afford Critical Control Over the Mineralization of the Postnatal Murine Skeleton

Advanced Science, EarlyView.
Biomineralization underpins skeletal development, yet its molecular control remains incompletely understood. Using a novel murine knockout model, this study reveals the essential and complementary roles of PHOSPHO1 and TNAP in postnatal skeletal development.
Lucie E. Bourne, Aikta Sharma, Scott Dillon, Jacob Keen, Soher N. Jayash, Natalie Crump, Lucinda A.E. Evans, Maya Karmali, Worachet Promruk, Claire E. Clarkin, Sonoko Narisawa, Louise Stephen, Brian L. Foster, José Luis Millán, Colin Farquharson, Katherine A. Staines   +15 more
wiley   +1 more source

Studies on lumbar endplate thickness, strength and bone mineral density (BMD).

, 2021
Studies on lumbar endplate thickness, strength and bone mineral density (BMD).
Alejandro A. Espinoza Orías (8677053), Hiroe Miyamoto (5562340), Howard S. An (6671918), Nozomu Inoue (689171), Koji Kanzaki (8555910), Kazuyuki Segami (5558363)   +5 more
core   +1 more source

Towards a Compositional Framework for Describing Human Phenotypes

Advanced Science, EarlyView.
The Phenotype Assembly Method (PhenoAM) decomposes phenotype variables into measurable Features and typed Qualifiers, enabling standardized, machine‐readable Phenome Data Elements (PhenoDEs) that preserve measurement context. Applied in the International Human Phenome Project (IHPP), the framework yields 58 371 PhenoDEs and supports component‐level ...
Wanting Hu, Yunchao Ling, Xinyue Hu, Wei Chen, Rong Zhou, Xinhao Zhuang, Yanfeng Jiang, Jialu Zhao, Xingdong Chen, Jingchun Luo, Li Jin, Guoqing Zhang   +11 more
wiley   +1 more source

Chloroform associated with bone mineral density and bone mineral content in adults: A population-based cross-sectional research.

PLoS ONE
BackgroundBone mineral density is an important indicator of osteoporosis, and its variation with volatile organic compounds exposure has rarely been studied. However, the relationship between chloroform (an essential volatile organic compounds component)
Lin Li, Xuekui Liu, Xia Zhang, Yan Zhang, Qing Li, Houfa Geng, Li Shi, Ben Wang, Qinqin Qiu, Tianpei Yu, Yiquan Sang, Lyying Wang, Wei Xu, Jun Liang   +13 more
doaj   +1 more source

Puerarin‑Loaded pH‑Responsive ZIF‑90 Nanoparticles Ameliorate Osteoporosis via Enhancing H3K18 Lactylation and Suppressing Aberrant Osteoclast Activation

Advanced Science, EarlyView.
Schematic illustration of the mechanism by which ZIF‐90@PU alleviates osteoporosis via H3K18la‐mediated NFATc1 pathway suppression. ABSTRACT Osteoporosis is characterized by dysregulated osteoclast activity, leading to excessive bone resorption and structural damage.
Jiajia Lu, Yue Xi, Sheng Wang, Ye Chen, Jiajie Yang, Xiaojian Shi   +5 more
wiley   +1 more source

BONE MINERAL DENSITY (BMD) OF THE CLACANEUS BONE IN 72 DIALYSIS PATIENTS MEASURED BY ULTRASONIC BONE ABSORPTIOMETRY

The Japanese Journal of Urology, 1998
To determine what factors contribute to and change BMD in dialysis patients.Bone parameters, namely, osteosono-assessment index (calculated by speed of sound and transmission index) were measured at calcaneus bone by ultrasonic bone absorptiometry with an Aloka Acoustic Osteoscreener (Model AOS-100). Seventy two patients were 62.
Tokuda, Noriaki, Uozumi, Jiro, Kumazawa, Joichi, Yamasaki, Takenari, Kano, Motonori   +4 more
openaire   +3 more sources

Bone mineral density (BMD), trabecular bone score (TBS), body composition, strength, and performance in patients and controls.

, 2023
Bone mineral density (BMD), trabecular bone score (TBS), body composition, strength, and performance in patients and controls.
Luana Bassan Gusmon (17334327), Cesar Luiz Boguszewski (10353391), Andre Luiz Canteri (17334324), Victoria Zeghbi Cochenski Borba (4658884)   +3 more
core   +1 more source

An Injectable and Self‐Reinforced Piezoelectric Hydrogel for Irregular Bone Defects Regeneration: Dynamic Epigenetic Regulation Approach

Advanced Science, EarlyView.
An injectable and self‐reinforcing RSF‐based piezoelectric hydrogel conforms to irregular bone defects and progressively strengthens in situ, overcoming the trade‐off between injectability and mechanical stability. Mechanical loading generates bioelectrical cues that promote P300‐mediated H3K9 acetylation and upregulate PTH1R expression, thereby ...
Yu‐Kai Huang, Juan Li, Miao‐Miao Yang, Chao Jia, Quan‐Xin Gong, Guang‐Cheng Yuan, Dong Zhou, Wen‐Hui Shen, Zeng‐Gan Chen, Zhi‐Rui Dong, Jin‐Wang Huang, Jie Peng, Di‐Han Su, Ming‐Dong Zhao, Jian Dong, Li‐Bo Jiang   +15 more
wiley   +1 more source

Age‐Related Lamin B1 Deficiency Activates SLC7A11‐Dependent Disulfidptosis to Impair Osteogenesis via Intercepting Mitochondrial Fission

Advanced Science, EarlyView.
This study reveals that age‐related LMNB1 deficiency in mesenchymal stem cells epigenetically upregulates SLC7A11, triggering actin disulfidptosis and mitochondrial dysfunction. This cascade impairs bone formation in senile osteoporosis. Furthermore, researchers identified the FDA‐approved drug naldemedine as a targeted SLC7A11 inhibitor to reverse ...
Wenhui Yu, Qibo Li, Weihao Zhang, Guan Zheng, Junhua Chen, Yipeng Zeng, Zipeng Xiao, Zibin Chen, Ziqian Liu, Yangfeng Lin, Jiajie Lin, Zepeng Su, Zhongyu Xie   +12 more
wiley   +1 more source

Laboratory data and bone mineral density (BMD) at baseline.

, 2018
Laboratory data and bone mineral density (BMD) at baseline.
Masayuki Iyoda (425962), Daisuke Sanada (4006802), Makoto Watanabe (486986), Shohei Tachibana (3161523), Kei Matsumoto (425965), Ken Iseri (659386), Takashi Inoue (178378), Takanori Shibata (425963)   +7 more
core   +1 more source