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Bone Morphogenetic Protein-2 in Development and Bone Homeostasis [PDF]
Journal of Developmental Biology, 2020 Bone morphogenetic proteins (BMPs) are multi-functional growth factors belonging to the Transforming Growth Factor-Beta (TGF-β) superfamily. These proteins are essential to many developmental processes, including cardiogenesis, neurogenesis, and ...
Daniel Halloran +2 more
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Potentiating effect of AMD3100 on bone morphogenetic protein-2 induced bone regeneration [PDF]
Maxillofacial Plastic and Reconstructive SurgeryBackground AMD3100, a CXCR4 antagonist, is currently prescribed for activating the mobilization of hematopoietic stem cells. Recently, AMD3100 was shown to potentiate bone morphogenetic protein-2 (BMP-2)-induced bone formation by stimulating the ...
Gyu-Jo Shim +4 more
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Cell-permeable bone morphogenetic protein 2 facilitates bone regeneration by promoting osteogenesis [PDF]
Materials Today BioThe use of the FDA-approved osteoinductive growth factor BMP2 is widespread for bone regeneration. However, its clinical application has been hindered by limitations in cell permeability and a short half-life in circulation.
Mingu Kang +7 more
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Ectopic Laryngeal Ossification after Bone Morphogenetic Protein-2 [PDF]
Surgeries, 2021 We report two cases of ectopic bone formation in the head and neck following treatment with recombinant human bone morphogenetic protein-2 (rhBMP-2). Surgical pathologic data, laryngoscopy imaging, CT imaging, and patient medical history were obtained ...
Kirsten Wong +2 more
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Bone morphogenetic protein 2: heterologous expression and potential in bone regeneration
Actualidades Biológicas, 2021 Currently, bone morphogenetic protein 2 (BMP-2) is one of the two osteoinductive growth factors used in medical devices to promote bone formation. Typically, this protein is bought from commercial houses at high rates and in small quantities that are not
Andrea Mesa-Restrepo +2 more
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Bone morphogenetic protein-2-derived osteogenic peptide promotes bone regeneration via osteoblastogenesis [PDF]
Regenerative TherapyIntroduction: Bone morphogenetic protein (BMP)-2 plays a critical role in stimulating human mesenchymal stromal cells (hMSCs) differentiation, a key process in bone regeneration.
Jong-Bin Lee +6 more
doaj +2 more sources
Focused Ultrasound-Mediated Release of Bone Morphogenetic Protein 2 from Hydrogels for Bone Regeneration [PDF]
GelsAn ultrasound-responsive hydrogel system was developed that provides on-demand release when stimulated by focused ultrasound (fUS). Diels–Alder cycloadducts crosslinked polyethylene glycol (PEG) hydrogels and underwent a retrograde Diels–Alder reaction ...
Tyus J. Yeingst +6 more
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Delivery of bone morphogenetic protein-2 and substance P using graphene oxide for bone regeneration
International Journal of Nanomedicine, 2014 Wan-Geun La,1 Min Jin,1 Saibom Park,1,2 Hee-Hun Yoon,1 Gun-Jae Jeong,1 Suk Ho Bhang,1 Hoyoung Park,1,2 Kookheon Char,1,2 Byung-Soo Kim1,31School of Chemical and Biological Engineering, Seoul National University, Seoul, Republic of Korea; 2The National ...
La WG +8 more
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Journal of the Formosan Medical Association, 2021 Background/Purpose: A synthetic bone morphogenetic protein (BMP)-2-derived peptide has been discovered to promote bone regeneration. The present study investigated the potential of the BMP-2 peptide combined with hydroxyapatite (HAp)/β-tricalcium ...
Yueh-Ling Chao +3 more
doaj +1 more source
Science Advances, 2021 The safety and efficacy of bone morphogenetic protein-2 is improved by the addition of a bridge protein in InFUSE Bone Graft. The revolutionizing efficacy of recombinant human bone morphogenetic protein (rhBMP-2) for clinical spinal fusion is hindered by
P. Briquez +3 more
semanticscholar +1 more source