Results 11 to 20 of about 27,732,661 (195)
Delivery of bone morphogenetic protein-2 and substance P using graphene oxide for bone regeneration
International Journal of Nanomedicine, 2014 In this study, we demonstrate that graphene oxide (GO) can be used for the delivery of bone morphogenetic protein-2 (BMP-2) and substance P (SP), and that this delivery promotes bone formation on titanium (Ti) implants that are coated with GO. GO coating
Wan‐Geun La +8 more
semanticscholar +2 more sources
Recombinant human bone morphogenetic protein-2 in the treatment of bone fractures
Biologics: Targets & Therapy, 2008 Neil Ghodadra, Kern SinghDepartment of Orthopedic Surgery, Rush University Medical Center, Chicago, Illinois, USAAbstract: Over one million fractures occur per year in the US and are associated with impaired healing increasing patient morbidity, stress ...
Neil Ghodadra, Kern Singh
doaj +1 more source
Limitations of bone formation in oral implantology: inhibition of osteoblast functions by gingival tissues [PDF]
, 2010 PhDClinical observation suggest that bone formation is influenced by the environmental niche where it takes place and specifically that soft connective tissues may inhibit the bone healing process.
Al-Masri, Maher
core +4 more sources
Science Advances, 2020 Heparin-based microparticles improve spatial localization of BMP-2 delivery, decreasing bone formation outside of the injury site. Supraphysiologic doses of bone morphogenetic protein-2 (BMP-2) are used clinically to promote bone formation in fracture ...
M. H. Hettiaratchi +5 more
semanticscholar +1 more source
Biomolecules, 2023 Despite the plethora of research that exists on recombinant human bone morphogenetic protein-2 and -7 (rhBMP-2 and rhBMP-7) and has been clinically approved, there is still a need to gain information that would allow for their more rational use in bone ...
Magdalena Wytrwal +6 more
doaj +1 more source
Novel fluorescent probes for analysis of protein interactions under truly physiological conditions with real medical devices [PDF]
, 2012 PhDProtein adsorption under physiological conditions was recognised to be the key step in the modulation of biological responses between materials and an osseous environment.
Mafina, Marc-Krystelle
core +4 more sources
Heterodimeric BMP-2/7 antagonizes the inhibition of all-trans retinoic acid and promotes the osteoblastogenesis. [PDF]
PLoS ONE, 2013 OBJECTIVES: Hypervitaminosis A and alcoholism can result in a low mineral density and compromised regenerative capacity of bone, thus delaying implant osteointegration.
Wenjuan Bi +5 more
doaj +1 more source
Recombinant Human Bone Morphogenetic Protein 2
Definitions, 2020 periodontal tissues In order to clarify whether bone morphogenetic protein (BMP) was effective and useful in periodontal regenerative therapy, three experiments were performed.
G. Mandelaris, D. Spagnoli, A. Rosenfeld
semanticscholar +1 more source
Acta Biomedica Scientifica, 2016 Modern therapeutic strategies for intervertebral disc repair mainly focus on targeting molecular pathways of extracellular matrix degeneration. Anabolic strategies for regeneration are aimed to increase production of major extracellular molecules ...
L. A. Bardonova +2 more
doaj +1 more source
USP15 targets ALK3/BMPR1A for deubiquitylation to enhance bone morphogenetic protein signalling [PDF]
, 2014 Protein kinase ALK3/BMPR1A mediates bone morphogenetic protein (BMP) signalling through phosphorylation and activation of SMADs 1/5/8. SMAD6, a transcriptional target of BMP, negatively regulates the BMP pathway by recruiting E3 ubiquitin ligases and ...
Bruce, David +11 more
core +1 more source