Results 31 to 40 of about 27,732,661 (195)

Use of recombinant human bone morphogenetic protein-2 in spine surgery

World Journal of Orthopaedics, 2017
Bone morphogenetic proteins are osteoinductive factors which have gained popularity in orthopaedic surgery and especially in spine surgery. The use of recombinant human bone morphogenetic protein-2 has been officially approved by the United States Food ...
M. Lykissas, I. Gkiatas
semanticscholar   +1 more source

Adsorption and release of BMP-2 on nanocrystalline apatite-coated and uncoated hydroxyapatite/b-tricalcium phosphate porous ceramics [PDF]

, 2009
The association of bone morphogenetic proteins (BMPs) with calcium phosphate bioceramics is known to confer them osteoinductive properties. The aim of this study was to evaluate the surface properties, especially regarding recombinant human BMP-2 (rhBMP-
Christèle Combes, Briand-Mésange, Fabienne, Fabienne Briand‐Mésange, Combes, Christèle, Gonçalvès, Stéphane, Drouet, Christophe, Stéphane Gonçalvès, Fourmy, Daniel, Swider, Pascal, Rey, Christian, Hélène Autefage, Christophe Drouet, Salles, Jean-Pierre, Sophie Cazalbou, Jean‐Pierre Salles, Cazalbou, Sophie, Pascal Swider, Christian Rey, Autefage, Hélène, Daniel Fourmy   +19 more
core   +1 more source

Sustained Release of Bone Morphogenetic Protein 2 via Coacervate

Foot & Ankle Orthopaedics, 2016
Category: Basic Sciences/Biologics Introduction/Purpose: Currently, there is no cure for osteoarthritis (OA) with treatment aimed at symptom relief and improved function.
MaCalus V. Hogan MD, Justin H. Hicks, Biomedical Engineering, Jorge L. Rocha BA, Hongshuai Li MD, PhD, Yadong Wang, Johnny Huard   +6 more
doaj   +1 more source

Kielin/chordin‐like protein enhances induction of osteoblast differentiation by Bone Morphogenetic Protein‐2

FEBS Open Bio, 2023
Bone morphogenetic proteins (BMPs) play a key role in embryonic differentiation for osteoblast and bone formation. Kielin/chordin‐like protein (Kcp) is known to enhance the effects of BMP signaling.
Kei Nagasaki, Atsushi Yamada, Kiyohito Sasa, Ryutaro Kamijo   +3 more
doaj   +1 more source

Recombinant human bone morphogenetic protein-2 stimulates osteoblastic maturation and inhibits myogenic differentiation in vitro

Journal of Cell Biology, 1991
The in vitro effect of recombinant human bone morphogenetic protein-2 (rhBMP-2) on osteogenic and myogenic differentiation was examined in two clonal cell lines of rat osteoblast-like cells at different differentiation stages, ROB-C26 (C26) and ROB-C20 ...
Akira Yamaguchi, T. Katagiri, T. Ikeda, J. Wozney, Vicki Rosen, Elizabeth A. Wang, A. Kahn, T. Suda, S. Yoshiki   +8 more
semanticscholar   +1 more source

The effect of bone morphogenetic protein-2 on osteosarcoma metastasis. [PDF]

PLoS ONE, 2017
PURPOSE:Bone Morphogenetic Protein-2 (BMP-2) may offer the potential to enhance allograft-host osseous union in limb-salvage surgery following osteosarcoma resection.
Jonathan Gill, Patrick Connolly, Michael Roth, So Hak Chung, Wendong Zhang, Sajida Piperdi, Bang Hoang, Rui Yang, Hillary Guzik, Jonathan Morris, Richard Gorlick, David S Geller   +11 more
doaj   +1 more source

BMP4 Induces Cardiomyocyte Hypertrophy Through the Activation of ERK 1/2 Signaling Pathway in H9c2 Cells [PDF]

Brazilian Archives of Biology and Technology
Bone morphogenetic protein-4 (BMP4) is a member of the bone morphogenetic protein family which plays an important role in bone formation, inflammation and cardiac hypertrophy.
Yu Yuan, Yezheng Tao, Yongzhi Deng, Qunhui Ye, Bin Lin, Lin Wu   +5 more
doaj   +2 more sources

Preparation of Recombinant Bone Morphogenetic Protein 2 at Laboratory Scale

Regeneration, Reconstruction & Restoration, 2016
Introduction: Millions cases of bone fracture are reported annually worldwide. The conventional methods for the repair often fail. The complications of using routine methods include stimulation of bone repair which should be performed without infection ...
Mahmoud Kazemi, Ali Hassani, Mojgan Bandehpour, Bahram Kazemi   +3 more
doaj   +1 more source

Combination of bone morphogenetic protein-2 plasmid DNA with chemokine [PDF]

European Cells & Materials, 2015
Bone morphogenetic protein-2 (BMP-2) gene delivery has shown to induce bone formation in vivo in cell-based tissue engineering. In addition, the chemoattractant stromal cell-derived factor-1α (SDF-1α, also known as CXCL12) is known to recruit multipotent
F Wegman, MT Poldervaart, YJ van der Helm, FC Oner, WJ Dhert, J Alblas   +5 more
doaj   +1 more source

Development, In-Vitro Characterization and In-Vivo Osteoinductive Efficacy of a Novel Biomimetically-Precipitated Nanocrystalline Calcium Phosphate With Internally-Incorporated Bone Morphogenetic Protein-2

Frontiers in Bioengineering and Biotechnology, 2022
The repair of large-volume bone defects (LVBDs) remains a great challenge in the fields of orthopedics and maxillofacial surgery. Most clinically available bone-defect-filling materials lack proper degradability and efficient osteoinductivity.
Gaoli Xu, Gaoli Xu, Chenxi Shen, Chenxi Shen, Haiyan Lin, Haiyan Lin, Jian Zhou, Ting Wang, Ben Wan, Ben Wan, Munerah Binshabaib, Tymour Forouzanfar, Guochao Xu, Nawal Alharbi, Gang Wu, Gang Wu   +15 more
doaj   +1 more source