Cell-permeable bone morphogenetic protein 2 facilitates bone regeneration by promoting osteogenesis
Materials Today BioThe use of the FDA-approved osteoinductive growth factor BMP2 is widespread for bone regeneration. However, its clinical application has been hindered by limitations in cell permeability and a short half-life in circulation.
Mingu Kang +7 more
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Accelerators of Osteogenesis by Recombinant Human Bone Morphogenetic Protein-2
Drug Target Insights, 2007 Bone morphogenetic protein (BMP) appears to be one of the most promising cytokine and for clinical use in reconstructive surgery for bony defects and augmentation.
Yasunori Okubo +2 more
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Identification of a bone morphogenetic protein type 2 receptor neutralizing antibody
BMC Research Notes, 2019 Objective The bone morphogenetic protein (BMP) signaling pathway comprises the largest subdivision of the transforming growth factor (TGFβ) superfamily.
Ruthann E. Gorrell +7 more
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Journal of Applied Oral Science, 2012 Bone morphogenetic protein type 2 (BMP-2) is a potent local factor, which promotes bone formation and has been used as an osteogenic supplement for mesenchymal stem cells.
Ariadne Cristiane Cabral Cruz +3 more
doaj
, 2023 Nohe, AnjaBones are complex systems that are necessary for the protection of internal organs, structure of the human skeleton, and locomotion. There are different types of bones comprised of multiple layers.
Halloran, Daniel R.
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Regulation of scleral fibroblast differentiation by bone morphogenetic protein-2
International Journal of Ophthalmology, 2014 Bone morphogenesis proteins (BMPs) are multi-functional growth factors. They are expressed in retina, retinal pigment epithelium (RPE) and sclera and serve as a regulator in the growth and development of the eye.
Hong-Hui Li +4 more
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Turning Bone Morphogenetic Protein 2 (BMP2) On and Off in Mesenchymal Cells
Journal of Cellular Biochemistry, 2015 The concentration, location, and timing of bone morphogenetic protein 2 (BMP2, HGNC:1069, GeneID: 650) gene expression must be precisely regulated.
M. Rogers, T. Shah, Nadia N. Shaikh
semanticscholar +1 more source
RGMa and RGMb expression pattern during chicken development suggest unexpected roles for these repulsive guidance molecules in notochord formation, somitogenesis, and myogenesis [PDF]
, 2012 Background: Repulsive guidance molecules (RGM) are high-affinity ligands for the Netrin receptor Neogenin, and they are crucial for nervous system development including neural tube closure; neuronal and neural crest cell differentiation and axon guidance.
Coutinho, L. +9 more
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Gremlin1 preferentially binds to bone morphogenetic protein-2 (BMP-2) and BMP-4 over BMP-7.
Biochemical Journal, 2015 Gremlin (Grem1) is a member of the DAN family of secreted bone morphogenetic protein (BMP) antagonists. Bone morphogenetic protein-7 (BMP-7) mediates protective effects during renal fibrosis associated with diabetes and other renal diseases.
Rachel H. Church +12 more
semanticscholar +1 more source
A STUDY OF THE BONE MORPHOGENETIC PROTEIN DERIVED FROM BOVINE DEMINERALIZED DENTIN MATRIX [PDF]
, 1996 1996-03-29We tried to extract and purify bone morphogenetic protein (BMP) from bovine demineralized dentin matrix (DDM). Crude dentin BMP (d-BMP) was extracted from DDM in 3 sequential steps.
MIZUTANI, HIDEKI +3 more
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