Results 11 to 20 of about 205,288 (347)

Recombinant Human Bone Morphogenetic Protein 2 [PDF]

Definitions, 2020
periodontal tissues In order to clarify whether bone morphogenetic protein (BMP) was effective and useful in periodontal regenerative therapy, three experiments were performed.
G. Mandelaris, Daniel B. Spagnoli, A. Rosenfeld   +2 more
semanticscholar   +2 more sources

Interleukin 17 enhances bone morphogenetic protein-2-induced ectopic bone formation [PDF]

Scientific Reports, 2018
Interleukin 17 (IL-17) stimulates the osteogenic differentiation of progenitor cells in vitro through a synergy with bone morphogenetic protein (BMP)-2. This study investigates whether the diverse responses mediated by IL-17 in vivo also lead to enhanced
M. Croes, M. C. Kruyt, W. M. Groen, K. M. A. van Dorenmalen, W. J. A. Dhert, F. C. Öner, J. Alblas   +6 more
doaj   +4 more sources

Recombinant Human Bone Morphogenetic Protein-2 and Collagen for Bone Regeneration

Journal of Biomedical Materials Research, 1998
The study reported describes a combination of recombinant human bone morphogenetic protein-2 (rhBMP-2) and collagen (C) to regenerate bone. Unilateral critical-sized defects (CSDs) were prepared in radii of 32 skeletally mature New Zealand white rabbits.
Buck, David C, Hollinger, Jeffrey O, Joh, Seong-Pil, Schmitt, John M, Shannon, Robert, Wozney, John, Zegzula, H Daniel   +6 more
core   +4 more sources

Bone morphogenetic protein‐2 and bone therapy: successes and pitfalls [PDF]

Journal of Pharmacy and Pharmacology, 2016
Abstract Objectives Bone morphogenetic proteins (BMPs), more specifically BMP-2, are being increasingly used in orthopaedic surgery due to advanced research into osteoinductive factors that may enhance and improve bone therapy.
Bonnie Poon, Tram Kha, Sally Tran, C. Dass   +3 more
semanticscholar   +4 more sources

Bone Morphogenetic Protein-2 Stimulates Runx2 Acetylation [PDF]

Journal of Biological Chemistry, 2006
Runx2/Cbfa1/Pebp2aA is a global regulator of osteogenesis and is crucial for regulating the expression of bone-specific genes. Runx2 is a major target of the bone morphogenetic protein (BMP) pathway. Genetic analysis has revealed that Runx2 is degraded through a Smurf-mediated ubiquitination pathway, and its activity is inhibited by HDAC4.
Eun-Joo, Jeon, Kwang-Youl, Lee, Nam-Sook, Choi, Mi-Hye, Lee, Hyun-Nam, Kim, Yun-Hye, Jin, Hyun-Mo, Ryoo, Je-Yong, Choi, Minoru, Yoshida, Norikazu, Nishino, Byung-Chul, Oh, Kyeong-Sook, Lee, Yong Hee, Lee, Suk-Chul, Bae   +13 more
openaire   +2 more sources

Heparin-mediated delivery of bone morphogenetic protein-2 improves spatial localization of bone regeneration

Science Advances, 2020
Heparin-based microparticles improve spatial localization of BMP-2 delivery, decreasing bone formation outside of the injury site. Supraphysiologic doses of bone morphogenetic protein-2 (BMP-2) are used clinically to promote bone formation in fracture ...
Marian H. Hettiaratchi, Laxminarayanan Krishnan, T. Rouse, Catherine Chou, T. McDevitt, R. Guldberg   +5 more
semanticscholar   +1 more source

Cellular Response to Bone Morphogenetic Proteins-2 and -7 Covalently Bound to Photocrosslinked Heparin–Diazoresin Multilayer

Biomolecules, 2023
Despite the plethora of research that exists on recombinant human bone morphogenetic protein-2 and -7 (rhBMP-2 and rhBMP-7) and has been clinically approved, there is still a need to gain information that would allow for their more rational use in bone ...
Magdalena Wytrwal, Małgorzata Sekuła-Stryjewska, Agata Pomorska, Ewa Oclon, Ewa Zuba-Surma, Szczepan Zapotoczny, Krzysztof Szczubiałka   +6 more
doaj   +1 more source

Heterodimeric BMP-2/7 antagonizes the inhibition of all-trans retinoic acid and promotes the osteoblastogenesis. [PDF]

PLoS ONE, 2013
OBJECTIVES: Hypervitaminosis A and alcoholism can result in a low mineral density and compromised regenerative capacity of bone, thus delaying implant osteointegration.
Wenjuan Bi, Zhiyuan Gu, Yuanna Zheng, Xiao Zhang, Jing Guo, Gang Wu   +5 more
doaj   +1 more source

Bone Morphogenetic Protein-2 Induces Proinflammatory Endothelial Phenotype [PDF]

The American Journal of Pathology, 2006
The transforming growth factor-beta superfamily member bone morphogenetic protein-2 (BMP-2) is up-regulated in atherosclerotic arteries; however, its effects on the endothelium are not well characterized. Using microdissected coronary arterial endothelial cells (CAECs) and cultured primary CAECs, we demonstrated endothelial mRNA expression of BMP-2 and
Anna, Csiszar, Mansoor, Ahmad, Kira E, Smith, Nazar, Labinskyy, Qun, Gao, Gabor, Kaley, John G, Edwards, Michael S, Wolin, Zoltan, Ungvari   +8 more
openaire   +2 more sources

Bone morphogenetic protein-2 influence on metabolic activity and proteoglycan synthesis by intervertebral disc cells

Acta Biomedica Scientifica, 2016
Modern therapeutic strategies for intervertebral disc repair mainly focus on targeting molecular pathways of extracellular matrix degeneration. Anabolic strategies for regeneration are aimed to increase production of major extracellular molecules ...
L. A. Bardonova, E. G. Belykh, V. A. Byvaltsev   +2 more
doaj   +1 more source