Results 41 to 50 of about 213,459 (247)

Recombinant human bone morphogenetic protein-2 stimulates osteoblastic maturation and inhibits myogenic differentiation in vitro

Journal of Cell Biology, 1991
The in vitro effect of recombinant human bone morphogenetic protein-2 (rhBMP-2) on osteogenic and myogenic differentiation was examined in two clonal cell lines of rat osteoblast-like cells at different differentiation stages, ROB-C26 (C26) and ROB-C20 ...
Akira Yamaguchi, T. Katagiri, T. Ikeda, J. Wozney, Vicki Rosen, Elizabeth A. Wang, A. Kahn, T. Suda, S. Yoshiki   +8 more
semanticscholar   +1 more source

BMP4 Induces Cardiomyocyte Hypertrophy Through the Activation of ERK 1/2 Signaling Pathway in H9c2 Cells [PDF]

Brazilian Archives of Biology and Technology
Bone morphogenetic protein-4 (BMP4) is a member of the bone morphogenetic protein family which plays an important role in bone formation, inflammation and cardiac hypertrophy.
Yu Yuan, Yezheng Tao, Yongzhi Deng, Qunhui Ye, Bin Lin, Lin Wu   +5 more
doaj   +2 more sources

Development, In-Vitro Characterization and In-Vivo Osteoinductive Efficacy of a Novel Biomimetically-Precipitated Nanocrystalline Calcium Phosphate With Internally-Incorporated Bone Morphogenetic Protein-2

Frontiers in Bioengineering and Biotechnology, 2022
The repair of large-volume bone defects (LVBDs) remains a great challenge in the fields of orthopedics and maxillofacial surgery. Most clinically available bone-defect-filling materials lack proper degradability and efficient osteoinductivity.
Gaoli Xu, Gaoli Xu, Chenxi Shen, Chenxi Shen, Haiyan Lin, Haiyan Lin, Jian Zhou, Ting Wang, Ben Wan, Ben Wan, Munerah Binshabaib, Tymour Forouzanfar, Guochao Xu, Nawal Alharbi, Gang Wu, Gang Wu   +15 more
doaj   +1 more source

The Use of Bone Morphogenetic Protein in the Intervertebral Disk Space in Minimally Invasive Transforaminal Lumbar Interbody Fusion [PDF]

, 2019
Study Design: Retrospective Cohort. Objective: The objective of this study was to characterize one surgeon’s experience over a 10-year period using rhBMP-2 in the disk space for minimally invasive transforaminal lumbar interbody fusion (MIS TLIF ...
Anderson, Annis, Cahill, Carragee, Chen, Crandall, Djurasovic, Fan, Foley, Fu, Funao, Gianaris, Gu, Haid, Hoffmann, Hu, Kelly, Khan, Khan, Kim, McGirt, Phan, Phan, Rihn, Rihn, Sawchuk, Singh, Spitz, Wang   +28 more
core   +1 more source

Preparation of Recombinant Bone Morphogenetic Protein 2 at Laboratory Scale

Regeneration, Reconstruction & Restoration, 2016
Introduction: Millions cases of bone fracture are reported annually worldwide. The conventional methods for the repair often fail. The complications of using routine methods include stimulation of bone repair which should be performed without infection ...
Mahmoud Kazemi, Ali Hassani, Mojgan Bandehpour, Bahram Kazemi   +3 more
doaj   +1 more source

Combination of bone morphogenetic protein-2 plasmid DNA with chemokine [PDF]

European Cells & Materials, 2015
Bone morphogenetic protein-2 (BMP-2) gene delivery has shown to induce bone formation in vivo in cell-based tissue engineering. In addition, the chemoattractant stromal cell-derived factor-1α (SDF-1α, also known as CXCL12) is known to recruit multipotent
F Wegman, MT Poldervaart, YJ van der Helm, FC Oner, WJ Dhert, J Alblas   +5 more
doaj   +1 more source

Role of the bone morphogenic protein pathway in developmental haemopoiesis and leukaemogenesis [PDF]

, 2016
Myeloid leukaemias share the common characteristics of being stem cell-derived clonal diseases, characterised by excessive proliferation of one or more myeloid lineage.
Toofan, Parto, Wheadon, Helen
core   +1 more source

Effective Doses of Recombinant Human Bone Morphogenetic Protein-2 in Experimental Spinal Fusion [PDF]

, 1996
Study Design Nineteen dogs underwent L4-L5 intertransverse process fusions with either 58 μg, 115 μg, 230 μg, 460 μg, or 920 μg of recombinant human bone morphogenetic protein-2 carried by a polylactic acid polymer.
Dawson, Edgar G., Delamarter, Rick B., Kabo, J. Michael, Kanim, Linda E.A., Liu, David, Sandhu, Harvinder, Toth, Jeffrey M., Zeegen, Erik N.   +7 more
core   +1 more source

USP15 targets ALK3/BMPR1A for deubiquitylation to enhance bone morphogenetic protein signalling [PDF]

, 2014
Protein kinase ALK3/BMPR1A mediates bone morphogenetic protein (BMP) signalling through phosphorylation and activation of SMADs 1/5/8. SMAD6, a transcriptional target of BMP, negatively regulates the BMP pathway by recruiting E3 ubiquitin ligases and ...
Al-Salihi, Mazin A., Bruce, David, Cummins, Timothy D., Dingwell, Kevin S., Ewan, Richard, Herhaus, Lina, Macartney, Thomas, Sapkota, Gopal P., Smith, James C., Vogt, Janis, Wasmus, Lise, Weidlich, Simone   +11 more
core   +3 more sources

Bone Generation Following Repeated Administration of Recombinant Bone Morphogenetic Protein 2

Tissue Engineering and Regenerative Medicine, 2020
The delivery of recombinant human bone morphogenetic protein 2 (rhBMP2) by using various carriers has been used to successfully induce bone formation in many animal models. However, the effect of multiple administration of rhBMP2 on bone formation and BMP2 antibody production has not been determined.
Hye-Ju Son, Mi Nam Lee, Yuri Kim, Hyuck Choi, Byung-Chul Jeong, Sin-Hye Oh, Jung-Woo Kim, Seung-Hee Kwon, Sun-Hun Kim, Soo-Chang Song, Shee Eun Lee, Jeong-Tae Koh   +11 more
openaire   +3 more sources