The Use of Recombinant Human Bone Morphogenetic Protein 2 (rhBMP-2) to Promote Spinal Fusion in a Nonhuman Primate Anterior Interbody Fusion Model [PDF]
, 1999 Study Design. A study on the efficacy of recombinant human bone morphogenetic protein 2 (rhBMP-2) in a nonhuman primate anterior interbody fusion model. Objectives.
Fischgrund, Jeffrey S. +5 more
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Novel signaling pathways in pulmonary arterial hypertension (2015 Grover Conference Series) [PDF]
, 2016 The proliferative endothelial and smooth muscle cell phenotype, inflammation, and pulmonary vascular remodeling are prominent features of pulmonary arterial hypertension (PAH).
Awad, Keytam S. +3 more
core +1 more source
Neonatal exposure to xenoestrogens impairs the ovarian response to gonadotropin treatment in lambs [PDF]
, 2015 Bisphenol A (BPA) and diethylstilbestrol (DES) are xenoestrogens which have been associated with altered effects on reproduction. We hypothesized that neonatal xenoestrogen exposure affects the ovarian functionality in lambs.
Belmonte, Norberto Miguel +8 more
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Gremlin1 preferentially binds to bone morphogenetic protein-2 (BMP-2) and BMP-4 over BMP-7.
Biochemical Journal, 2015 Gremlin (Grem1) is a member of the DAN family of secreted bone morphogenetic protein (BMP) antagonists. Bone morphogenetic protein-7 (BMP-7) mediates protective effects during renal fibrosis associated with diabetes and other renal diseases.
Rachel H. Church +12 more
semanticscholar +1 more source
Efficacy of copolymer scaffolds delivering human demineralised dentine matrix for bone regeneration
Journal of Tissue Engineering, 2019 Poly(L-lactide-co-ε-caprolactone) scaffolds were functionalised by 10 or 20 µg/mL of human demineralised dentine matrix. Release kinetics up to 21 days and their osteogenic potential on human bone marrow stromal cells after 7 and 21 days were studied.
Arooj Munir +10 more
doaj +1 more source
Bone growth following demineralized bone matrix implantation requires angiogenesis [PDF]
, 2016 Angiogenesis is required for endochondral ossification during development and fracture healing; however the exact mechanisms and temporal relationship between the two processes remains unclear.
Lam, Stephanie
core
Endogenous musculoskeletal tissue engineering - a focused perspective [PDF]
, 2012 Two major difficulties facing widespread clinical implementation of existing Tissue Engineering (TE) strategies for the treatment of musculoskeletal disorders are (1) the cost, space and time required for ex vivo culture of a patient’s autologous cells ...
Adam, Clayton
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Role of bone morphogenetic protein-2 in osteogenic differentiation of mesenchymal stem cells
Molecular Medicine Reports, 2015 Bone mesenchymal stem cells (BMSCs) have been an area of interest in biomedical research and tissue engineering due to their diverse differentiation abilities.
Jian Sun, Jie Li, Chichi Li, Youcheng Yu
semanticscholar +1 more source
Erythropoietin Modulates the Structure of Bone Morphogenetic Protein 2–Engineered Cranial Bone [PDF]
Tissue Engineering Part A, 2012 The ideally engineered bone should have similar structural and functional properties to the native tissue. Although structural integrity is critical for functional bone regeneration, we know less about modulating the structural properties of the engineered bone elicited by bone morphogenetic protein (BMP) than efficacy and safety. Erythropoietin (Epo),
Sun, Hongli +4 more
openaire +3 more sources
Current Issues in Molecular BiologyOsteolforte, a compound with potential bone-regenerative properties, was investigated for its effects on human bone marrow stromal cells (hBMSCs). This study aimed to evaluate its impact on cell viability, osteogenic differentiation, and both gene and ...
Da-Sol Kim +4 more
doaj +1 more source