Results 91 to 100 of about 137,665 (299)

The Osteoblastic Microenvironment Determines the Fate of Breast Cancer Cells Disseminated in the Bone Marrow

Advanced Science, EarlyView.
This study revealed how the osteoblastic microenvironment determines the fate of cancer cells disseminated in bone, with a focus on whether they colonize, reside in quiescence, or reactivate from dormancy. Targeting integrin signaling may offer promising strategies for preventing quiescent cancer cells reactivation and bone colonization.
Hong‐Li Wang, Rui Zhang, Xiao‐Min Yue, Jie Zhou, Yu‐Fan Huang, Rong Meng, Yu‐Li Wang, Xiao‐Qing Li   +7 more
wiley   +1 more source

A clinically relevant model of osteoinduction: a process requiring calcium phosphate and BMP/Wnt signalling [PDF]

, 2010
In this study, we investigated a clinically relevant model of in vivo ectopic bone formation utilizing human periosteum derived cells (HPDCs) seeded in a Collagraft carrier and explored the mechanisms by which this process is driven.
Eyckmans, Jeroen, Luyten, F. P., Roberts, S. J., Schrooten, J.   +3 more
core   +1 more source

Genomics Insights Into High‐Latitude Adaptation of Tibetan Macaques

Advanced Science, EarlyView.
Tibetan macaques exhibit unique adaptations to cold, high‐latitude environments, including shortened tails and enhanced fat storage. Genomic analyses reveal a species‐specific TBX6 mutation linked to tail reduction and selection on lipid metabolism genes.
Rusong Zhang, Ying Hu, Yang Teng, Jiwei Qi, Yangzhen Ciren, Lin Zhang, Qiao Du, Wencai Xu, Liang Zhou, Zhenxin Fan, Jinchuan Xing, Ming Li, Jing Li   +12 more
wiley   +1 more source

Differences in the pattern and regulation of mineral deposition in human cell lines of osteogenic and non-osteogenic origin [PDF]

, 2011
Bone marrow-derived mesenchymal stem cells (MSCs) are widely used as a cellular model of bone formation, and can mineralize in vitro in response to osteogenic medium (OM).
Alexander J. Blake, Amatschek S., Andrews P.W., Andrews P.W., Beresford J.N., Blumberg P., Boland G.M., Bonewald L.F., Boskey A.L., Boskey A.L., Boylan M.O., Briggs T., Bruder S.P., Buttery L.D., Cancedda R., Chadalavada R.S., Cheng S.L., Clover J., Cristina Tufarelli, Declercq H.A., Draper J.S., Duran C., Eijken M., Gang E.J., Gentleman E., Gey G.O., Graham F.L., Gregory C.A., Halleux C., Hassan Rashidi, Hui M., Iba K., Ilse G., Izbicka E., Jackson L., Jaiswal N., Jaiswal R.K., Jorgensen N.R., Kasten P., Khosla S., Khouja H.I., Kimelman N., Kniss D.A., Kochanowska I.E., Kochanowska I.E., Koeneman K.S., Leigh Jackson, Lin D.L., Liu F., Louise France, Maeda S., Mareschi K., Marie P.J., Markovic M., McCulloch C.A., Morgan M.P., Okamoto T., Ostrowski K., Pal R., Palmieri A., Park K.W., Pautke C., Pera M.F., Peter S.J., Pittenger M.F., Poliard A., Rago R., Rodríguez J.P., Russell R.G., Seib F.P., Shukunami C., Simoes P.D., Song I.H., Sottile V., Sottile V., Spandan Kalra, Spiropoulos A., Stephanie Strohbuecker, Tang N., Tataria M., Tenenbaum H.C., Thomas P., Tremoleda J.L., Virginie Sottile, Yu P.B., Zayzafoon M., zur Nieden N.I.   +86 more
core   +1 more source

Navigating the Ethereal Tightrope: The Nanogenerator Manipulates Neurons for Immune Equilibrium

Advanced Science, EarlyView.
This review explores how nanogenerators modulate neuroimmune responses, offering innovative strategies for treating neurological disorders. By interfacing with neural pathways, they enable precise control of immune activity, especially via vagus nerve stimulation.
Jia Du, Rui Deng, Ya Wu, Hong‐Xia Ren, Zong‐Hong Lin, Yang‐Bao Miao   +5 more
wiley   +1 more source

Efficacy of copolymer scaffolds delivering human demineralised dentine matrix for bone regeneration

Journal of Tissue Engineering, 2019
Poly(L-lactide-co-ε-caprolactone) scaffolds were functionalised by 10 or 20 µg/mL of human demineralised dentine matrix. Release kinetics up to 21 days and their osteogenic potential on human bone marrow stromal cells after 7 and 21 days were studied.
Arooj Munir, Anne Døskeland, Steven J Avery, Tiziana Fuoco, Samih Mohamed-Ahmed, Henning Lygre, Anna Finne-Wistrand, Alastair J Sloan, Rachel J Waddington, Kamal Mustafa, Salwa Suliman   +10 more
doaj   +1 more source

Controlled spatial and conformational display of immobilised bone morphogenetic protein-2 and osteopontin signalling motifs regulates osteoblast adhesion and differentiation in vitro

BMC Biology, 2010
Background The interfacial molecular mechanisms that regulate mammalian cell growth and differentiation have important implications for biotechnology (production of cells and cell products) and medicine (tissue engineering, prosthetic implants, cancer ...
McCaskie Andrew W, Chaffey Benjamin T, Mitchell Elizabeth A, Lakey Jeremy H, Birch Mark A   +4 more
doaj   +1 more source

Activating the Osteoblastic USP26 Pathway Alleviates Multi‐Organ Fibrosis by Decreasing Insulin Resistance

Advanced Science, EarlyView.
The loss of Ubiquitin Specific Peptidase 26 (USP26) in osteoblasts results in decreased bone formation, as well as multi‐organ fibrosis associated with insulin resistance (IR). Mechanistically, the absence of USP26 reduces glycolysis and lactate accumulation, leading to decreased histone H3 lysine 18 lactylation (H3K18LA) in the promoter region of KH ...
Jiyuan Tang, Wenkai Ye, Liang He, Zhou Dan, Leilei Chang, Zijie You, Yuanyue Jiang, Guoqing Tang, Lianfu Deng, Changwei Li   +9 more
wiley   +1 more source

The TGFβ type I receptor TGFβRI functions as an inhibitor of BMP signaling in cartilage. [PDF]

, 2019
The type I TGFβ receptor TGFβRI (encoded by Tgfbr1) was ablated in cartilage. The resulting Tgfbr1 Col2 mice exhibited lethal chondrodysplasia. Similar defects were not seen in mice lacking the type II TGFβ receptor or SMADs 2 and 3, the intracellular ...
Baek, Jongseung, Chun, Hyelim, Lopez, Noah, Lyons, Karen M, Razavi, Peyman, Sadik, Joshua Elyahu, Shirazyan, Anna, Wang, Weiguang   +7 more
core  

Regulation of Phosphatase Homologue of Tensin Protein Expression by Bone Morphogenetic Proteins in Prostate Epithelial Cells [PDF]

, 2010
Phosphatase homologue of tensin (PTEN) is the key endogenous inhibitor of phosphoinositide signaling and is the most commonly mutated gene in human prostate cancer.
Dan Theodorescu, Travis Jerde, Wade Bushman, Zhong Wu   +3 more
core   +2 more sources