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Growth Factors, 2003
Bone morphogenetic proteins (BMPs) are multi-functional growth factors that belong to the transforming growth factor beta (TGFbeta) superfamily. The roles of BMPs in embryonic development and cellular functions in postnatal and adult animals have been extensively studied in recent years. Signal transduction studies have revealed that Smad1, 5 and 8 are
Di, Chen, Ming, Zhao, Gregory R, Mundy
+7 more sources
Bone morphogenetic proteins (BMPs) are multi-functional growth factors that belong to the transforming growth factor beta (TGFbeta) superfamily. The roles of BMPs in embryonic development and cellular functions in postnatal and adult animals have been extensively studied in recent years. Signal transduction studies have revealed that Smad1, 5 and 8 are
Di, Chen, Ming, Zhao, Gregory R, Mundy
+7 more sources
Genes and Function, 1997
The concept that there is a substance in bone that can induce new-bone formation has been discussed for many years. However, the credit for the discovery of bone morphogenetic protein goes to Marshall R. Urist, who, in 1965, demonstrated the formation of bone by a process that he called autoinduction.
N, Ueno, M, Moos
+5 more sources
The concept that there is a substance in bone that can induce new-bone formation has been discussed for many years. However, the credit for the discovery of bone morphogenetic protein goes to Marshall R. Urist, who, in 1965, demonstrated the formation of bone by a process that he called autoinduction.
N, Ueno, M, Moos
+5 more sources
Biochemical and Biophysical Research Communications, 2007
Bone morphogenetic proteins (BMPs) are multi-functional growth factors belonging to the transforming growth factor-beta superfamily. It has been demonstrated that BMPs had been involved in the regulation of cell proliferation, survival, differentiation and apoptosis.
Yong-Tao, Xiao +2 more
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Bone morphogenetic proteins (BMPs) are multi-functional growth factors belonging to the transforming growth factor-beta superfamily. It has been demonstrated that BMPs had been involved in the regulation of cell proliferation, survival, differentiation and apoptosis.
Yong-Tao, Xiao +2 more
openaire +2 more sources
Journal of neurosurgery. Spine, 2009
Although the authors used the same interbody spacers and even higher dose of rhBMP-2 (than the dose of rhBMP-2 was used in another report in which incidence of the resorptions after interbody fusions assisted with rhBMP-2 was 100%) there was no resorptions in their study. We asked for the authors' clarification of the strange phenomenon.
Smoljanović, Tomislav +2 more
openaire +4 more sources
Although the authors used the same interbody spacers and even higher dose of rhBMP-2 (than the dose of rhBMP-2 was used in another report in which incidence of the resorptions after interbody fusions assisted with rhBMP-2 was 100%) there was no resorptions in their study. We asked for the authors' clarification of the strange phenomenon.
Smoljanović, Tomislav +2 more
openaire +4 more sources
Journal of Dental Research, 1971
Bone morphogenetic protein (BMP) made by the process comprising the steps of demineralizing bone tissue; treating the demineralized bone tissue under aqueous conditions with a water soluble neutral salt and a solubilizing agent for the BMP, the agent being selected from the group consisting of urea and guanidine, and thereby transforming the bone ...
M R, Urist, B S, Strates
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Bone morphogenetic protein (BMP) made by the process comprising the steps of demineralizing bone tissue; treating the demineralized bone tissue under aqueous conditions with a water soluble neutral salt and a solubilizing agent for the BMP, the agent being selected from the group consisting of urea and guanidine, and thereby transforming the bone ...
M R, Urist, B S, Strates
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Bone morphogenetic proteins in bone tumors
Journal of Orthopaedic Science, 2004Bone morphogenetic proteins (BMPs), inducers of ectopic bone formation in vivo, are present in a number of osteosarcomas. BMPs are responsible for reactive bone formation, including periosteal reactions by normal osteoblasts, rather than production of tumorous osteoid by tumor cells.
Hideki, Yoshikawa +3 more
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Progress in Growth Factor Research, 1989
Bone Morphogenetic Protein (BMP) refers to an activity derived from bone that induces the formation of cartilage and bone in vivo. This activity leads to a series of developmental processes including chemotaxis, proliferation, and differentiation, which result in the transient formation of cartilage and the production of living bone tissue, complete ...
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Bone Morphogenetic Protein (BMP) refers to an activity derived from bone that induces the formation of cartilage and bone in vivo. This activity leads to a series of developmental processes including chemotaxis, proliferation, and differentiation, which result in the transient formation of cartilage and the production of living bone tissue, complete ...
openaire +2 more sources
Bone Morphogenetic Protein Gene Therapy
Spine, 2002A retrospective analysis of previous BMP gene therapy and general gene therapy publications.To present the potential role of BMP gene therapy for the induction of osteogenesis and spinal fusion.A variety of viral and non-viral techniques have been utilized to insert foreign transgenes into cells, both in vivo and in vitro.
Tord D, Alden +4 more
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