Results 231 to 240 of about 183,822 (327)

Extracellular matrix and proteolysis: mechanisms driving irreversible changes and shaping cell behavior

The FEBS Journal, EarlyView.
Irreversible ECM proteolysis by remodeling enzymes shapes development, homeostasis, and disease. ECM‐degrading proteases display cell specificity and are governed by shared mechanisms, exhibiting functional redundancy in generating matrikines, growth factors, and cytokines.
Inna Solomonov, Orit Kollet, Irit Sagi
wiley   +1 more source

Bone morphogenetic protein 4 expressed in esophagitis induces a columnar phenotype in esophageal squamous cells.

Gastroenterology, 2007
F. Milano, J. V. van Baal, N. Buttar, A. Rygiel, F. D. de Kort, C. Demars, W. Rosmolen, J. Bergman, J. van Marle, Kenneth K Wang, M. Peppelenbosch, K. Krishnadath   +11 more
semanticscholar   +1 more source

Interactions between small leucine‐rich proteoglycans and proteases: implications for tissue homeostasis and pathology

The FEBS Journal, EarlyView.
Small leucine‐rich proteoglycans (SLRPs) are key modulators of extracellular matrix structure and signaling. Their proteolytic processing by MMPs (Matrix Metalloproteinases), ADAMTS (disintegrin and metalloprotease with thrombospondin motifs), and serine proteases generates bioactive fragments that regulate collagen remodeling, inflammation, and ...
Maria Konstantaraki, Lydia‐Nefeli Thrapsanioti, Aikaterini Berdiaki, Ioanna Spyridaki, Dragana Nikitovic   +4 more
wiley   +1 more source

Stimulation of Epithelial Sodium Channels in Endothelial Cells by Bone Morphogenetic Protein-4 Contributes to Salt-Sensitive Hypertension in Rats. [PDF]

Oxid Med Cell Longev, 2020
Yang X, Niu N, Liang C, Wu MM, Tang LL, Wang QS, Lou J, Song BL, Zheng WW, Ma HP, Zhang ZR.   +10 more
europepmc   +1 more source

An update on the landscape of collagen bioactive fragments

The FEBS Journal, EarlyView.
The remodeling of the extracellular matrix releases collagen bioactive fragments, which exert molecular functions and regulate numerous biological processes via several signaling pathways. Here, we summarize the latest findings describing the roles of major bioactive fragments from collagens I, IV, VI, and XVIII in various physiological and ...
Sylvie Ricard‐Blum, Julie Fradette
wiley   +1 more source

Correction to "CD34dim Cells Identified as Pluripotent Stem Cell-Derived Definitive Hemogenic Endothelium Purified Using Bone Morphogenetic Protein 4". [PDF]

Cell Prolif
europepmc   +1 more source

Beyond the chaos: How architecture structures tumour biology

The FEBS Journal, EarlyView.
Tissue architecture shapes tumour initiation and progression through multiple interconnected layers continuously remodelled over time. This review outlines how physical forces, biochemical cues, cellular niches and systemic influences contribute to tumour evolution.
Lea Dörner, Catrin Lutz, Stefan Prekovic, Hendrik A. Messal   +3 more
wiley   +1 more source

Impact of long-lasting spontaneous physical activity on bone morphogenetic protein 4 in the heart and tibia in murine model of heart failure. [PDF]

Physiol Rep, 2020
Majerczak J, Filipowska J, Tylko G, Guzik M, Karasinski J, Piechowicz E, Pyza E, Chlopicki S, Zoladz JA.   +8 more
europepmc   +1 more source

Proteolysis at the extracellular matrix interface: Molecular architects and regulators in health and disease

The FEBS Journal, EarlyView.
The extracellular matrix (ECM) is a dynamic scaffold that orchestrates tissue architecture and cellular communication. A critical but underexplored interplay between proteases and cluster of differentiation molecules (CD) governs ECM turnover and directs cell fate.
David Jurnečka, Matija Hrovatin, Bor Bokalj, Boris Turk   +3 more
wiley   +1 more source

Modifications of hyaluronan influence the interaction with human bone morphogenetic protein-4 (hBMP-4).

Biomacromolecules, 2009
V. Hintze, S. Moeller, M. Schnabelrauch, S. Bierbaum, M. Viola, H. Worch, D. Scharnweber   +6 more
semanticscholar   +1 more source