Results 271 to 280 of about 178,667 (323)

A review of xenobiotic membrane transporter expression within the human placenta: Lessons gained from primary tissue and in vitro methodologies

The Journal of Physiology, EarlyView.
Abstract figure legend A summary of the current knowledge around membrane transporter expression in the most widely used in vitro models of human trophoblasts, including primary placental tissue, cancer cell lines and trophoblast stem cells, as well as the techniques to attempt to mimic the human placenta in vivo.
Rhiannon Pass, Kathryn Wolton, Amanda N. Sferruzzi‐Perri   +2 more
wiley   +1 more source

The role of vitamin D receptor signaling in hair follicle health and alopecia: Current understanding and therapeutic implications

Journal of Cell Communication and Signaling, Volume 20, Issue 1, March 2026.
The vitamin D receptor (VDR) regulates hair follicle biology through ligand‐dependent and ligand‐independent mechanisms by heterodimerizing with retinoid X receptor, recruiting coactivator complexes, and activating target genes including Wnt inhibitors, hair keratins, and cell cycle regulators.
Liancheng Guan, Fan Yang, Meijuan Li, Yujia Chen, Zexin Zhao, Hongxia Li, Deping Luo, Qian Li, Yunzhi Chen   +8 more
wiley   +1 more source

Effects of 17α‐Ethinylestradiol on Development and Gonadal Differentiation in the Estuarine Mummichog, Fundulus heteroclitus

Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, Volume 345, Issue 2, Page 148-161, March 2026.
ABSTRACT In fish, sex determination and gonadal development are controlled by various genetic and environmental factors. In this study, experiments were conducted on the estuarine mummichog (Fundulus heteroclitus) to investigate gonadal differentiation following exposure to the synthetic estrogen, 17α‐ethinylestradiol (EE2).
Ibrahim Chehade, Carly Sing‐Judge, Emily Corrigan, Andrea Lister, Glen Van Der Kraak, Deborah MacLatchy   +5 more
wiley   +1 more source

Targeting Delivery of Cyanidin‐Loaded With Ti3C2 Nanosheets for Alleviating Vascular Calcification in Chronic Kidney Disease

MedComm – Biomaterials and Applications, Volume 5, Issue 1, March 2026.
Vascular calcification significantly elevates cardiovascular risk in CKD patients, yet no effective therapies exist to halt its progression. We developed a dual targeting nanoplatform Ti3C2/RANKL/OCN/Cyanidin (TROC) for the targeted delivery of cyanidin against vascular calcification.
Li Yin, Xiaoge Zhang, Huanji Zhang, Changming Xie, Zhengzhipeng Zhang, Dong Wang, Yuning Liu, Bing Dong, Leilei Shi, Jie Liu, Hui Huang   +10 more
wiley   +1 more source

Roles of bone morphogenetic protein 4 in liver fibrogenesis

, 2007
openaire   +1 more source

Anti-inflammatory properties of bone morphogenetic protein 4 in human adipocytes [PDF]

International Journal of Obesity, 2016
Obesity is characterized by increased adipocyte number and size as well as white adipose tissue (WAT) inflammation, which is fundamental for the development of insulin resistance and type-2 diabetes. These processes, regulated by various endocrine, paracrine and autocrine factors, are extensively studied with the hope to interfere and to inhibit weight
Elena Baraban, Trian Chavakis, Bradford S. Hamilton, Susanne Sales, Susanne Sales, Martin Wabitsch, Stefan R. Bornstein, M. Ehrhart‐Bornstein   +7 more
semanticscholar   +3 more sources

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Bone morphogenetic protein 4 alleviates pulmonary fibrosis by regulating macrophages

International Immunopharmacology, 2023
Fibrosis is a pathological change mainly characterized by an increase of fibrous connective tissue and decrease of parenchymal cells. Its continuous progress may lead to the destruction of organ structure and function decline. An excess of alternatively activated M2 macrophages have been considered crucial candidates in the progression of fibrosis ...
Yiyang Jiang, Yingyi Chen, Jingfei Fu, Rui Zhao, Junji Xu, Yi Liu   +5 more
openaire   +2 more sources

Bone morphogenetic protein-4

The International Journal of Biochemistry & Cell Biology, 1996
Bone morphogenic protein-4 (BMP-4) is one of nine structurally related BMPs belonging to the transforming growth factor-beta (TGF-beta) superfamily of secreted proteins. Mature BMP-4 is a dimer that binds to a multimeric transmembrane receptor with serine/threonine kinase activity.
L M, Leong, P M, Brickell
openaire   +2 more sources

Bone Morphogenetic Protein‐2 Antagonizes Bone Morphogenetic Protein‐4 Induced Cardiomyocyte Hypertrophy and Apoptosis

Journal of Cellular Physiology, 2014
Our previous work showed that the expression of bone morphogenetic protein‐4 (BMP4) was up‐regulated in pathological cardiac hypertrophy models and BMP4 induced cardiomyocyte hypertrophy and apoptosis. Bone morphogenetic protein‐2 (BMP2) and BMP4 share greater than 80% amino acid homology and there exists an interaction between BMP2 and BMP4, so the ...
Jing, Lu, Bo, Sun, Rong, Huo, Yu-Chun, Wang, Di, Yang, Yue, Xing, Xiao-Lin, Xiao, Xin, Xie, De-Li, Dong   +8 more
openaire   +2 more sources