Results 271 to 280 of about 183,822 (327)

Geleophysic Dysplasia Associated With FBN1 Mutation: Clinical Course, Valvular Heart Disease, and Response to Recombinant Human Growth Hormone Therapy

Clinical Case Reports, Volume 14, Issue 4, April 2026.
ABSTRACT Geleophysic dysplasia (GD) is a rare genetic condition caused by pathogenic variants in either the ADAMTSL2 or FBN1 gene. We present a patient that combined clinical features consistent with GD, including short stature, delayed bone age, progressive congenital heart disease, and a happy, round face.
Ray Thomas Katbe, Laure Boutsen, Philippe A. Lysy   +2 more
wiley   +1 more source

Adventitial Niches, Complement and Inflammation in Pulmonary Vascular Disease: Current Status and Future Directions

Comprehensive Physiology, Volume 16, Issue 2, April 2026.
Local complement production by pulmonary artery adventitial fibroblasts, activated intracellularly by CFD and CFB and extracellularly by GZMK+ CD8 T cells, and its secretion in soluble form and within EVs promotes macrophage and T cell chemotaxis and activation.
Hui Zhang, Ram Raj Prasad, Sushil Kumar, Min Li, Dallas Jones, Cheng‐Jun Hu, Claudia Mickael, Yen‐Rei Yu, Rubin M. Tuder, Kurt R. Stenmark   +9 more
wiley   +1 more source

The Importance of Liver‐Lung Communication in Pulmonary Vascular Diseases

Comprehensive Physiology, Volume 16, Issue 2, April 2026.
Schematic depicting the key drivers of liver‐lung communication in pulmonary vascular diseases, including hepatic dysfunction, portosystemic shunting, and gut microbial dysbiosis, which together drive pulmonary vascular remodeling. ABSTRACT In normal health, the liver and lungs enjoy a close anatomic, physiologic, and functional relationship.
Navneet Singh, Hilary M. DuBrock, Sasha Z. Prisco, Zhiyu Dai, Qi Zheng, Michael B. Fallon, Thenappan Thenappan, Corey E. Ventetuolo, Arun Jose   +8 more
wiley   +1 more source

Roles of bone morphogenetic protein 4 in liver fibrogenesis

, 2007
openaire   +1 more source

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Bone Morphogenetic Protein‐2 Antagonizes Bone Morphogenetic Protein‐4 Induced Cardiomyocyte Hypertrophy and Apoptosis

Journal of Cellular Physiology, 2014
Our previous work showed that the expression of bone morphogenetic protein‐4 (BMP4) was up‐regulated in pathological cardiac hypertrophy models and BMP4 induced cardiomyocyte hypertrophy and apoptosis. Bone morphogenetic protein‐2 (BMP2) and BMP4 share greater than 80% amino acid homology and there exists an interaction between BMP2 and BMP4, so the ...
Jing Lu, Bo Sun, Rong Huo, Yu-Chun Wang, Di Yang, Yue Xing, Xiao-Lin Xiao, Xin Xie, De-Li Dong   +8 more
semanticscholar   +3 more sources

Bone morphogenetic protein 4 inhibits liposaccharide‐induced inflammation in the airway

European Journal of Immunology, 2014
Bone morphogenetic protein 4 (BMP4) is a multifunctional growth factor that belongs to the TGF‐β superfamily. The role of BMP4 in lung diseases is not fully understood. Here, we demonstrate that BMP4 was upregulated in lungs undergoing lipopolysaccharide (LPS)‐induced inflammation, and in airway epithelial cells treated with LPS or TNF‐α.
Zhengtu Li, Jian Wang, Yan Wang, Hua Jiang, Xiaoming Xu, Chenting Zhang, Defu Li, Chuyi Xu, K. Zhang, Ya-fei Qi, Xuefang Gong, Chunfang Tang, N. Zhong, Wenju Lu   +13 more
semanticscholar   +3 more sources

Bone morphogenetic protein 4 alleviates pulmonary fibrosis by regulating macrophages

International Immunopharmacology, 2023
Fibrosis is a pathological change mainly characterized by an increase of fibrous connective tissue and decrease of parenchymal cells. Its continuous progress may lead to the destruction of organ structure and function decline. An excess of alternatively activated M2 macrophages have been considered crucial candidates in the progression of fibrosis ...
Yiyang Jiang, Yingyi Chen, Jingfei Fu, Rui Zhao, Junji Xu, Yi Liu   +5 more
openaire   +2 more sources

Bone morphogenetic protein-4

The International Journal of Biochemistry & Cell Biology, 1996
Bone morphogenic protein-4 (BMP-4) is one of nine structurally related BMPs belonging to the transforming growth factor-beta (TGF-beta) superfamily of secreted proteins. Mature BMP-4 is a dimer that binds to a multimeric transmembrane receptor with serine/threonine kinase activity.
L M, Leong, P M, Brickell
openaire   +2 more sources

The Role of Bone Morphogenetic Protein 4 in Lung Diseases

Current Molecular Medicine, 2023
: Bone morphogenetic protein 4 (BMP4) is a multifunctional secretory protein that belongs to the transforming growth factor β superfamily. BMPs transduce their signaling to the cytoplasm by binding to membrane receptors of the serine/threonine kinase family, including BMP type I and type II receptors. BMP4 participates in various biological processes,
Xiaoxiao, Dong, Yimin, Mao, Pengfei, Gao
openaire   +2 more sources