Results 281 to 290 of about 178,667 (323)

The Role of Bone Morphogenetic Protein 4 in Lung Diseases

Current Molecular Medicine, 2023
: Bone morphogenetic protein 4 (BMP4) is a multifunctional secretory protein that belongs to the transforming growth factor β superfamily. BMPs transduce their signaling to the cytoplasm by binding to membrane receptors of the serine/threonine kinase family, including BMP type I and type II receptors. BMP4 participates in various biological processes,
Xiaoxiao, Dong, Yimin, Mao, Pengfei, Gao
openaire   +2 more sources

Bone Morphogenetic Protein-4 Regulation in Fibrodysplasia Ossificans Progressiva

Clinical Orthopaedics and Related Research, 2003
Fibrodysplasia ossificans progressiva is a rare genetic disorder in which connective tissues are replaced with heterotopic bone through an endochondral process. Bone morphogenetic protein-4 messenger ribonucleic acid and protein levels are elevated in the cells of patients with fibrodysplasia ossificans progressiva, but the molecular mechanism of this ...
Elizabeth A, Olmsted, Frederick S, Kaplan, Eileen M, Shore   +2 more
openaire   +2 more sources

Bone Morphogenetic Protein-4 Control of Pituitary Pathophysiology

2006
Bone morphogenetic protein-4 (BMP-4), a member of the transforming growth factor-Beta(TGF-Beta) family, is overexpressed in different prolactinoma models and induces the development of these lineage adenomas. SMAD proteins activated by growth factors of the TGF-Beta and BMP family interact with estrogen receptors to stimulate the proliferation of ...
Giacomini, D., Páez-Pereda, M., Theodoropoulou, M., Gerez, J., Nagashima, A., Chervin, A., Berner, S., Labeur, M., Refojo, D., Renner, U., Stalla, G., Arzt, E.   +11 more
openaire   +3 more sources

Potent Ectopic Bone-Inducing Activity of Bone Morphogenetic Protein-4/7 Heterodimer

Biochemical and Biophysical Research Communications, 1995
We have purified and characterized recombinant Xenopus bone morphogenetic proteins (xBMPs): homodimers of xBMP-4, 7 and heterodimers (xBMP-4/7) produced by a baculovirus expression system. Highly purified xBMPs had homogeneous NH2-termini predicted from a consensus motif, Arg-X-X-Arg, while they possessed diverse sugar chains.
A, Aono, M, Hazama, K, Notoya, S, Taketomi, H, Yamasaki, R, Tsukuda, S, Sasaki, Y, Fujisawa   +7 more
openaire   +2 more sources

Ectopic bone formation by electroporatic transfer of bone morphogenetic protein-4 gene

Bone, 2002
Orthopedic surgeons have long awaited the clinical application of bone morphogenetic proteins (BMPs) for bone regeneration. However, such possible applications involving proteins or genes transferred with virus vectors have encountered many problems, including high cost, immunological reactions, viral infection, etc.
K N, Kishimoto, Y, Watanabe, H, Nakamura, S, Kokubun   +3 more
openaire   +2 more sources

Use of Monoclonal Antibody to Detect Bone Morphogenetic Protein-4 (BMP-4)

Bone, 1995
A monoclonal antibody that reacts with murine and human bone morphogenetic protein-4 (BMP-4) has been developed using recombinant BMP-4 as an immunogen. The antibody that bound most tightly to recombinant murine (rm)BMP-4 was selected, subcloned, and characterized.
K, Masuhara, T, Nakase, S, Suzuki, K, Takaoka, M, Matsui, H C, Anderson   +5 more
openaire   +2 more sources

The role of bone morphogenetic protein 4 in corneal injury repair

Experimental Eye Research, 2021
Corneal injury may cause neovascularization and lymphangiogenesis in cornea which have a detrimental effect to vision and even lead to blindness. Bone morphogenetic protein 4 (BMP4) regulates a variety of biological processes, which is closely relevant to the regulation of corneal epithelium and angiogenesis.
Huicong Hu, Shurong Wang, Yuxi He, Sitong Shen, Boyuan Yao, Duo Xu, Xin Liu, Yan Zhang   +7 more
openaire   +2 more sources

Bone morphogenetic protein 4 inhibits liposaccharide‐induced inflammation in the airway

European Journal of Immunology, 2014
Bone morphogenetic protein 4 (BMP4) is a multifunctional growth factor that belongs to the TGF‐β superfamily. The role of BMP4 in lung diseases is not fully understood. Here, we demonstrate that BMP4 was upregulated in lungs undergoing lipopolysaccharide (LPS)‐induced inflammation, and in airway epithelial cells treated with LPS or TNF‐α.
Zhengtu Li, Jian Wang, Yan Wang, Hua Jiang, Xiaoming Xu, Chenting Zhang, Defu Li, Chuyi Xu, K. Zhang, Ya-fei Qi, Xuefang Gong, Chunfang Tang, N. Zhong, Wenju Lu   +13 more
semanticscholar   +3 more sources

Bone morphogenetic protein‐4 regulates its own expression in cultured osteoblasts

Journal of Cellular Physiology, 2000
During development, bone morphogenetic proteins (BMPs) induce the differentiation of mesenchymal progenitor cells to enter into the osteoblastic lineage, and BMPs enhance osteoblastic function. BMPs and noggin, a specific binding protein that blocks BMP actions, are expressed by osteoblastic cells but there is limited information about regulation of ...
R C, Pereira, S, Rydziel, E, Canalis
openaire   +2 more sources

Regulating the Role of Bone Morphogenetic Protein 4 in Tooth Bioengineering

Journal of Oral and Maxillofacial Surgery, 2007
Culture of the whole organ and regulation of its development using biologic and engineering principles can be used to produce structures and organs for reconstructing defects. The application of these bioengineering approaches in artificial tooth development may be the alternative way to replace missing dentition.For the artificial bioengineering of a ...
Il-Hyuk, Chung, Pill-Hoon, Choung, Hyun-Jeong, Ryu, Young-Ho, Kang, Han-Wool, Choung, Jong-Hoon, Chung, Yun-Hoon, Choung   +6 more
openaire   +2 more sources