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Characterization of Bone Morphogenetic Protein 4 Receptor in Fibrodysplasia Ossificans Progressiva
Clinical Orthopaedics and Related Research, 1998Bone morphogenetic protein 4, a potent osteogenic morphogen, has been implicated in fibrodysplasia ossificans progressiva because it is uniquely overexpressed in lymphoblastoid cells and preosseous fibroproliferative lesional cells of patients with fibrodysplasia ossificans progressiva. Bone morphogenetic protein 4 signals through a heteromeric complex
T F, Lanchoney +6 more
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Steroids, 2013
Imbalanced functions of osteoclasts and osteoblasts are involved in various types of bone damage including postmenopausal osteoporosis. In the present study, we investigated the cellular mechanism by which estrogen interacts in the process of osteoblastic differentiation regulated by BMP-4 using mouse MC3T3-E1 cells that express estrogen receptors (ER)
Yoshinori, Matsumoto +8 more
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Imbalanced functions of osteoclasts and osteoblasts are involved in various types of bone damage including postmenopausal osteoporosis. In the present study, we investigated the cellular mechanism by which estrogen interacts in the process of osteoblastic differentiation regulated by BMP-4 using mouse MC3T3-E1 cells that express estrogen receptors (ER)
Yoshinori, Matsumoto +8 more
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Bone morphogenetic protein-2 and -4 expression during murine orofacial development
Archives of Oral Biology, 1995In the developing orofacial region, epithelial-mesenchymal interactions induce a differentiation cascade leading to bone and cartilage formation. Although the nature of this interaction is unknown, bone morphogenetic proteins (BMP)-2 and -4 have been suggested as putative signalling molecules.
J H, Bennett, P, Hunt, P, Thorogood
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[Bone morphogenetic protein-4 regulates embryonic tongue morphogenesis].
Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences, 2010To analyze the effect of Bone morphogenesis 4 and its antagonist Noggin on morphogenesis of tongue.Dissected rats to get embryonic day 13 (E13) tongues; fed E13 tongues in standard medium, BMP4 (0.03 mg/L, 0.3 mg/L, 1 mg/L), and the antgonist Noggin(1 mg/L, 3 mg/L, 10 mg/L) medium; cultured for 3 days; fixed samples, observed tongues with scanning ...
Yan-qiu, Zhou, Jiu-xiang, Lin
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Bone morphogenetic protein 4—a fascinating regulator of cancer cell behavior
Cancer Genetics, 2012Bone morphogenetic proteins (BMPs) are extracellular signaling molecules that belong to the transforming growth factor β (TGFβ) superfamily and are well-known for their indispensable roles in vertebrate development. In recent years, important new information has been generated on the contribution of BMP family members, such as BMP4, in cancer ...
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The contemporary management of cancers of the sinonasal tract in adults
Ca-A Cancer Journal for Clinicians, 2023Rajat Thawani
exaly