Results 101 to 110 of about 1,418,143 (292)

Computer-aided scaffold design optimization towards enhanced bone regeneration

Large bone defects remain a clinical challenge, with a gold standard treatment - autologous bone graft - that presents many drawbacks. Design optimized scaffolds appear as a promising alternative [1]; however, bone scaffold design remains a trial and ...
Checa Esteban, Sara
core   +1 more source

Magnetically Driven Biofabrication for Tissue Engineering: From Nanoparticle Design to Mag‐ATMP Translation

Advanced Healthcare Materials, EarlyView.
Magnetically responsive nanoparticles enable remote control over biomaterials, cells, and engineered tissues. This review summarizes material design, biological safety, fabrication and actuation strategies, computational validation, and translational pathways that support the development of magnetic tissue‐engineering platforms and future magnetically ...
Konstantinos Ioannidis, Dimitrios Lefas, Maya Guilliams, Jackie Van Grootenbril, Isaak Decoene, Dimitrios Sakellariou, Bart Smeets, Stefanos Mourdikoudis, Ioannis Papantoniou   +8 more
wiley   +1 more source

Zwitterionic Polymer Coating Enabled Chronic Dopamine Sensing and Electrophysiology Recording in Free‐Moving Mice

Advanced Healthcare Materials, EarlyView.
Application of a zwitterionic poly(sulfobetaine methacrylate) (PSB) coating to microelectrode arrays and Ag/AgCl reference electrodes effectively inhibits biofouling and structural degradation. This strategy successfully enables simultaneous, long‐term electrophysiological recording and dopamine sensing in freely behaving mice, facilitating ...
Bingchen Wu, Cort Thompson, Thomas Deakin, Yan Xu, Colleen A. McClung, Xinyan Tracy Cui   +5 more
wiley   +1 more source

PLL‐g‐HPA Hydrogel Microneedles Loaded With Rhoifolin Target Macrophages to Alleviate Fibroblast Senescence for Diabetic Wound Healing

Advanced Healthcare Materials, EarlyView.
Diabetic wound healing is hindered by a pathological crosstalk wherein elevated IL‐11 induces M1 macrophage polarization, leading to IL‐1β/IL‐6 release and subsequent fibroblast senescence via RAS/p38MAPK/p53/E2F1 signaling. Here, we develop a Gel@M‐Rho microneedle patch that delivers rhoifolin‐loaded, macrophage membrane‐coated nanoparticles to target
Jiewen Liao, Lin Gan, Li Lu, Lizhi Ouyang, Yuan Xiong, Fawwaz Al‐Smadi, Guandong Dai, Mohammad‐Ali Shahbazi, Bobin Mi, Mengfei Liu, Guohui Liu   +10 more
wiley   +1 more source

Análise do padrão de regeneração óssea guiada por membranas de ácido polilático co-glicólico (PLGA) associado ou não à hidroxiapatia (PLGA+HA) em defeitos ósseos na calota craniana de ratos [PDF]

, 2014
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Odontologia, Florianópolis, 2014.Abstract : Objective: To evaluate in vivo the bone repair in the use of poly lactic acid co ...
Alécio, Artur Breno Wanderley
core  

Engineering Niches for Bone Tissue Regeneration

, 2017
This chapter places the topics from previous chapters into the context of bone tissue regeneration. The chapter introduces bone as a tissue and as a complex organ and discusses the clinical need for bone regeneration strategies.
Habibovic, Pamela; id_orcid, Van Blitterswijk, Clemens, Angad Malhotra, Clemens van Blitterswijk, Pamela Habibovic, Malhotra, Angad, Habibovic, Pamela   +6 more
core   +1 more source

Author Correction: Combination of IL-6 and sIL-6R differentially regulate varying levels of RANKL-induced osteoclastogenesis through NF-κB, ERK and JNK signaling pathways

Scientific Reports, 2022
Wei Feng, Hongrui Liu, Tingting Luo, Di Liu, Juan Du, Jing Sun, Wei Wang, Xiuchun Han, Kaiyun Yang, Jie Guo, Norio Amizuka, Minqi Li   +11 more
doaj   +1 more source

Spatial Control of Light‐Responsive Proteins and Optogenetics Within Hydrogels via Volumetric Bioprinting

Advanced Materials, EarlyView.
Spatiotemporal control over cell behavior within bioprinted constructs remains a key challenge in biofabrication. Volumetric bioprinting using multi‐wavelength light sources permits to activate light‐sensitive intracellular proteins as well as optogenetic gene and protein expression circuits in bioprinted cells, in addition to enabling fast printing of
Davide Ribezzi, Pere Català, Gabriel Größbacher, Paulina Nuñez Bernal, Olaf Nijssen, Sammy Florczak, Wilco Nijenhuis, Nuria Crusellas‐Villorbina, Bram Nijhoff, Paul Delrot, Jos Malda, Andreas Hierholzer, Martin Fussenegger, Lukas C. Kapitein, Riccardo Levato   +14 more
wiley   +1 more source

Breaking the Surface: Buoyant Metal–Polymer Open–Cell Hybrid Lattice Metamaterials

Advanced Materials, EarlyView.
Open‐cell metal–polymer lattice metamaterials that defy sinking. (a) Injection process of the polyurethane (PU) foam into the titanium (Ti‐6Al‐4V) hollow‐strut lattice creating the open‐cell Ti‐6Al‐4V+PU hybrid lattice, (b) flotation test of a hybrid lattice specimen, and (c) a digital representation and experimental validation of a marine buoy ...
Jordan Noronha, Joey Tallon, Raad Omar, Jason Dash, Andrey Molotnikov, Martin Leary, Milan Brandt, Ma Qian   +7 more
wiley   +1 more source

Human bone tissue-derived ECM hydrogels: Controlling physicochemical, biochemical, and biological properties through processing parameters

Bioactive Materials
Decellularized tissues offer significant potential as biological materials for tissue regeneration given their ability to preserve the complex compositions and architecture of the native extracellular matrix (ECM).
Yang-Hee Kim, Gianluca Cidonio, Janos M. Kanczler, Richard OC. Oreffo, Jonathan I. Dawson   +4 more
doaj   +1 more source