Results 91 to 100 of about 1,418,143 (292)

Risperidone induces osteoporosis and neuropsychiatric treatment resistance via SMPD1-lysosome-mediated ferroptosis: dual rescue by active vitamin D analog ED-71

Journal of Advanced Research
Introduction: Risperidone (RIS), a second-generation antipsychotic for schizophrenia (SZ), is linked to osteoporosis and suboptimal symptom resolution. The shared cellular mechanisms underlying these cross-tissue toxicities (bone and hippocampus) remain ...
Yajun Cui, Ke Ma, Lingshuang Li, Xuejie Lin, Yu Ji, Haipeng Si, Hongrui Liu, Minqi Li   +7 more
doaj   +1 more source

Harnessing Nanotopography to Enhance Osseointegration of Clinical Orthopedic Titanium Implants—An in Vitro and in Vivo Analysis

Frontiers in Bioengineering and Biotechnology, 2018
Despite technological advancements, further innovations in the field of orthopedics and bone regeneration are essential to meet the rising demands of an increasing aging population and associated issues of disease, injury and trauma.
Vitali Goriainov, Gry Hulsart-Billstrom, Terje Sjostrom, Douglas G. Dunlop, Bo Su, Richard O. C. Oreffo   +5 more
doaj   +1 more source

Dynamic Loading Regulates Meniscus‐Like Matrix Production in Human Mesenchymal Stromal Cell‐Seeded PET Scaffolds

Advanced Healthcare Materials, EarlyView.
Dynamic compression enhances mesenchymal stromal cell proliferation in nonwoven PET scaffolds under chondrogenic differentiation conditions and triggers mechanosensitive transcriptional programs associated with extracellular matrix remodeling. These findings highlight the potential of mechanically stimulated PET scaffolds as a promising platform for ...
Graciosa Quelhas Teixeira, Luisa de Roy, Anna‐Lotta Feldmeier, Mubashir Ahmad, Sofia Pilão, Maria Ahrens, Anita Ignatius, Carsten Linti, Andreas Martin Seitz   +8 more
wiley   +1 more source

Implantation of silicon dioxide-based nanocrystalline hydroxyapatite and pure phase beta-tricalciumphosphate bone substitute granules in caprine muscle tissue does not induce new bone formation [PDF]

, 2013
Background: Osteoinductive bone substitutes are defined by their ability to induce new bone formation even at heterotopic implantation sites. The present study was designed to analyze the potential osteoinductivity of two different bone substitute ...
Künzel, Oliver, Shahram Ghanaati, Ines Willershausen, Ghanaati, Shahram Michael, Samuel E. Udeabor, Robert A. Sader, Oliver Kuenzel, Sader, Robert Alexander, Udeabor, Samuel Ebele, Kirkpatrick, Charles James, C. James Kirkpatrick, Willershausen, Ines Bettina Anne, Mike Barbeck, Barbeck, Mike   +13 more
core   +2 more sources

AGEs impair osteogenesis in orthodontic force-induced periodontal ligament stem cells through the KDM6B/Wnt self-reinforcing loop

Stem Cell Research & Therapy
Background Diabetes, occasionally diagnosed in orthodontic patients, can impede orthodontic tooth movement (OTM) by accumulating advanced glycation end products (AGEs) in the periodontium.
Qiaohui Ying, Yujun Jiang, Changyun Sun, Yaoguang Zhang, Ruihan Gao, Hongrui Liu, Hongrui Liu, Jie Guo, Minqi Li   +8 more
doaj   +1 more source

Trends in Fracture-Related Hospitalizations and Mortality in Brazil, 2015–2024

Epidemiologia
Background/Objectives: Bone fractures represent a growing public health concern worldwide, yet national epidemiological assessments remain limited in Brazil.
Palloma Porto Almeida, Danielle Cabral Bonfim   +1 more
doaj   +1 more source

How is Nanoarchitectonics Shaping Extracellular Vesicle Research?

Advanced Healthcare Materials, EarlyView.
The convergence of nanoarchitectonics and extracellular vesicle biology is reshaping next‐generation nanomedicine by enabling rationally designed nanostructures for enhanced EVs detection, engineering, and therapy. ABSTRACT Extracellular vesicles (EVs) have gained recognition as crucial mediators of cell‐to‐cell communication, holding immense potential
Madushani Dahanayake, Md Shahriar A. Hossain, Chia‐Hung Liu, Carlos Salomon, Yusuke Yamauchi, Mostafa Kamal Masud   +5 more
wiley   +1 more source

Targeting CD300a Signaling With a Phosphatidylserine‐Presenting Hydrogel Rescues Macrophage Dysfunction and Accelerates Diabetic Wound Healing

Advanced Healthcare Materials, EarlyView.
Schematic illustration of the proposed mechanism: PEG/RGD‐PSLs mimic apoptotic cells to engage PS receptors (notably CD300a), transducing an inhibitory signal that suppresses the MyD88/NF‐κB pathway, leading to global anti‐inflammatory and pro‐reparative effects.
Lele Wu, Xuetong Hao, Yang Zou, Xinglin Chen, Junyan Kong, Chunning Gu, Wenjie Ma, Zhongjun Yang, Huifen Liu, Mengmeng Liu, Xin Tong   +10 more
wiley   +1 more source

IMP2 enhances M2 macrophage polarization via LKB1-AMPK-mediated mitochondrial dynamics and fatty acid β-oxidation to ameliorate diabetic osteoporosis

Cellular and Molecular Life Sciences
A reduction in M2 macrophage polarization is a key pathogenic contributor to diabetic osteoporosis (DOP). In this study, we revealed that IMP2 affects mitochondrial dynamics and fatty acid β-oxidation (FAO) via the LKB1-AMPK pathway, influencing the M2 ...
Lingshuang Li, Yajun Cui, Yu Ji, Ke Ma, Xuejie Lin, Ting Liu, Junyang Sun, Hongrui Liu, Jie Guo, Minqi Li   +9 more
doaj   +1 more source

Advancing Human Skin Equivalents: The Crucial Role of Neurovascular Integration

Advanced Healthcare Materials, EarlyView.
This review discusses the importance of integrating vascular and peripheral nerve systems into human skin equivalents (HSEs) to better recapitulate native skin physiology. Recent advances in vascularized, innervated, and neurovascularized HSEs are highlighted, together with emerging bioengineering strategies, current challenges, and future ...
Hao Wu, Lorenzo Moroni, Nicolas Lebonvallet, Vincent Flacher, Paul Wieringa   +4 more
wiley   +1 more source