Results 71 to 80 of about 4,056,235 (345)

Bone Tissue Engineering and Regeneration [PDF]

BioMed Research International, 2014
Bone tissue engineering and regeneration constitutes a burgeoning new area of investigation, incorporating scientists, engineers, and clinicians with diverse academic backgrounds. With an aging global population, the need to engineer and regenerate mesenchymal tissues becomes even more pressing.
Levi, Benjamin, Péault, Bruno, James, Aaron W   +2 more
openaire   +2 more sources

Synergistic effect of umbilical cord extracellular vesicles and rhBMP-2 to enhance the regeneration of a metaphyseal femoral defect in osteoporotic rats

Stem Cell Research & Therapy
Background The aim of this study was to evaluate potential synergistic effects of a single, local application of human umbilical cord MSC-derived sEVs in combination with a low dose of recombinant human rhBMP-2 to promote the regeneration of a ...
Amelie Deluca, Andrea Wagner, Patrick Heimel, Christian Deininger, Florian Wichlas, Heinz Redl, Eva Rohde, Herbert Tempfer, Mario Gimona, Andreas Traweger   +9 more
doaj   +1 more source

Comparison of bone formation mediated by bone morphogenetic protein delivered by nanoclay gels with clinical techniques (autograft and InductOs) in an ovine bone model

Journal of Tissue Engineering, 2022
Development of a growth factor delivery vehicle providing appropriate temporal-spatial release together with an appropriate preclinical large animal model to evaluate bone formation is critical in the development of delivery strategies for bone tissue ...
Cameron Black, David Gibbs, Josephine McEwan, Janos Kanczler, Marta Peña Fernández, Gianluca Tozzi, Jonathan Dawson, Richard Oreffo   +7 more
doaj   +1 more source

Strategies of functionalized GelMA-based bioinks for bone regeneration: Recent advances and future perspectives

Bioactive Materials
Gelatin methacryloyl (GelMA) hydrogels is a widely used bioink because of its good biological properties and tunable physicochemical properties, which has been widely used in a variety of tissue engineering and tissue regeneration. However, pure GelMA is
Yaru Zhu, Xing-Ge Yu, Hao Liu, Junjun Li, M. Gholipourmalekabadi, Kai-Li Lin, Chang-Yong Yuan, Penglai Wang   +7 more
semanticscholar   +1 more source

Resolution of inflammation in bone regeneration: from understandings to therapeutic applications

Biomaterials, 2021
Impaired bone healing occurs in 5–10% of cases following injury, leading to a significant economic and clinical impact. While an inflammatory response upon injury is necessary to facilitate healing, its resolution is critical for bone tissue repair as ...
Hunter Newman, Y. Shih, S. Varghese
semanticscholar   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Cell‐Laden Scaffolds for Vascular‐Innervated Bone Regeneration

, 2023
For regeneration of highly vascularized and innervated tissues, like bone, simultaneous ingrowth of blood vessels and nerves is essential but largely neglected.
Lei Chen, Hui Zhuang, Meng Zhang, Chen, Lei, Xiao, Yin, Wu, Chengtie, Chen Qin, Zhiguang Huan, Zhang, Hongjian, Qin, Chen, Jingge Ma, Zhuang, Hui, Yin Xiao, Huan, Zhiguang, Hongjian Zhang, Zhang, Meng, Chengtie Wu, Ma, Jingge   +17 more
core   +1 more source

Hydrothermal Synthesis of Fluorapatite Coatings over Titanium Implants for Enhanced Osseointegration—An In Vivo Study in the Rabbit

Journal of Functional Biomaterials, 2022
This work aims at the development and characterization of fluorapatite coatings, innovatively prepared by the hydrothermal method, aiming for enhanced osseointegration of titanium implants.
Eduardo Santiago, Victor Martin, Bruno Colaço, Maria Helena Fernandes, Catarina Santos, Pedro S. Gomes   +5 more
doaj   +1 more source

Angiogenesis is uncoupled from osteogenesis during calvarial bone regeneration

Nature Communications
Bone regeneration requires a well-orchestrated cellular and molecular response including robust vascularization and recruitment of mesenchymal and osteogenic cells.
M. G. Bixel, K. Sivaraj, M. Timmen, V. Mohanakrishnan, Anusha Aravamudhan, Susanne Adams, Bong-Ihn Koh, H. Jeong, Kai Kruse, R. Stange, R. Adams   +10 more
semanticscholar   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source