Results 61 to 70 of about 4,056,235 (345)

In Vitro Evaluation of a Nanoparticle-Based mRNA Delivery System for Cells in the Joint

Biomedicines, 2021
Biodegradable and bioresponsive polymer-based nanoparticles (NPs) can be used for oligonucleotide delivery, making them a promising candidate for mRNA-based therapeutics.
Lisa Sturm, Bettina Schwemberger, Ursula Menzel, Sonja Häckel, Christoph E. Albers, Christian Plank, Jaap Rip, Mauro Alini, Andreas Traweger, Sibylle Grad, Valentina Basoli   +10 more
doaj   +1 more source

Neurovascular coupling in bone regeneration

Experimental and Molecular Medicine, 2022
The mammalian skeletal system is densely innervated by both neural and vascular networks. Peripheral nerves in the skeleton include sensory and sympathetic nerves. The crosstalk between skeletal and neural tissues is critical for skeletal development and
Q. Qin, Seung-Yong Lee, Nirali Patel, Kalah Walden, M. Gomez-Salazar, Benjamin Levi, A. James   +6 more
semanticscholar   +1 more source

Injectable Scaffolds for Bone Regeneration [PDF]

Langmuir, 2014
Clinical treatments of significant bone defects involve invasive procedures such as the application of auto- and allografts. These procedures present many limitations including the potential for infection and rejection. There is therefore a need to develop novel therapeutic strategies able to exploit the natural regenerative potential of bone and that ...
Yasmeen, Sabina, Lo, Man Kit, Bajracharya, Salina, Roldo, Marta   +3 more
openaire   +4 more sources

Vertical bone regeneration with synthetic biomimetic calcium phosphate onto the calvaria of rats [PDF]

, 2019
International audienceBone regeneration is often required to provide adequate oral rehabilitation before dental implants. Vertical ridge augmentation is the most challenging of all situations, and often requires the use of autologous bone grafting ...
Maazouz, Yassine, Pastorino, David, Fellah, Borhane, Ginebra, Maria-Pau, Fellah, Borhane, H., Layrolle, Pierre, Fellah, Borhane,, Hoornaert, Alain, de Pinieux, Gonzague, Aparicio, Carlos, Ginebra Molins, Maria Pau, Layrolle, P, Pastorino Carraz, David   +12 more
core   +1 more source

Dynamic hydrogel–metal–organic framework system promotes bone regeneration in periodontitis through controlled drug delivery

Journal of Nanobiotechnology
Periodontitis is a prevalent chronic inflammatory disease, which leads to gradual degradation of alveolar bone. The challenges persist in achieving effective alveolar bone repair due to the unique bacterial microenvironment’s impact on immune responses ...
Qi-Pei Luo, Yuxin Yang, Chingchun Ho, Zongtai Li, Weicheng Chiu, Anqi Li, Yu Dai, Wei-Chang Li, Xinchun Zhang   +8 more
semanticscholar   +1 more source

Perfluorodecalin and bone regeneration

European Cells and Materials, 2013
Perfluorodecalin (PFD) is a chemically and biologically inert biomaterial and, as many perfluorocarbons, is also hydrophobic, radiopaque and has a high solute capacity for gases such as oxygen. In this article we have demonstrated, both in vitro and in vivo, that PFD may significantly enhance bone regeneration. Firstly, the potential benefit of PFD was
F Tamimi, P Comeau, D Le Nihouannen, YL Zhang, DC Bassett, S Khalili, U Gbureck, SD Tran, S Komarova, JE Barralet   +9 more
openaire   +3 more sources

Composite Hydrogels for Bone Regeneration [PDF]

Materials, 2016
Over the past few decades, bone related disorders have constantly increased. Among all pathological conditions, osteoporosis is one of the most common and often leads to bone fractures. This is a massive burden and it affects an estimated 3 million people only in the UK. Furthermore, as the population ages, numbers are due to increase. In this context,
Gianluca Tozzi, Arianna De Mori, Antero Oliveira, Marta Roldo   +3 more
openaire   +4 more sources

Early Stage Foreign Body Reaction against Biodegradable Polymer Scaffolds Affects Tissue Regeneration during the Autologous Transplantation of Tissue-Engineered Cartilage in the Canine Model

Cell Transplantation, 2012
To overcome the weak points of the present cartilage regenerative medicine, we applied a porous scaffold for the production of tissue-engineered cartilage with a greater firmness and a 3D structure.
Yukiyo Asawa, Tomoaki Sakamoto, Makoto Komura, Makoto Watanabe, Satoru Nishizawa, Yutaka Takazawa, Tsuyoshi Takato, Kazuto Hoshi M.D., Ph.D.   +7 more
doaj   +1 more source

Periosteum-bone inspired hierarchical scaffold with endogenous piezoelectricity for neuro-vascularized bone regeneration

Bioactive Materials
The development of scaffolds for repairing critical-sized bone defects heavily relies on establishing a neuro-vascularized network for proper penetration of nerves and blood vessels.
Yao Zhao, Yunfan Cai, Wenkai Wang, Yong-Kang Bai, Mingyi Liu, Yan Wang, Wen Niu, Zhi-Xiao Luo, Ling-yun Xia, Juanfang Zhu, Fei Zhao, Franklin R. Tay, L. Niu   +12 more
semanticscholar   +1 more source

Piezoresistive MXene/Silk fibroin nanocomposite hydrogel for accelerating bone regeneration by Re-establishing electrical microenvironment

Bioactive Materials, 2022
The electrical microenvironment plays an important role in bone repair. However, the underlying mechanism by which electrical stimulation (ES) promotes bone regeneration remains unclear, limiting the design of bone microenvironment–specific electroactive
Z. Hu, Jiaqi Lu, Tai-Wei Zhang, Haifeng Liang, Hao Yuan, Di-Han Su, Wang Ding, Rui-Xian Lian, Yueyang Ge, Bing-Chiang Liang, Jian Dong, Xiao-Gang Zhou, Li-Bo Jiang   +12 more
semanticscholar   +1 more source