Results 131 to 140 of about 1,336,774 (305)

In Situ Stress‐Dispersing Hydrogel Millispheres via Load Redistribution to Restore Nucleus Pulposus Metabolic Homeostasis

Advanced Science, EarlyView.
Local stress concentration disrupts metabolic homeostasis and induces inflammation in the nucleus pulposus (NP), thereby accelerating intervertebral disc degeneration (IDD). A biomimetic HA/ChS hydrogel millimeter sphere (ChS@HM) is developed to enable synergistic stress dispersion and sustained hydration lubrication.
Ang Li, Hui Yuan, Honglei Xiao, Xiaodong Liu, Wenguo Cui   +4 more
wiley   +1 more source

Fibroblast–immune crosstalk in oral squamous cell carcinoma: from tumor promotion to immune evasion

Frontiers in Immunology
Oral squamous cell carcinoma (OSCC) is a highly invasive malignancy marked by poor prognosis and therapeutic resistance. Within its tumor microenvironment (TME), cancer-associated fibroblasts (CAFs) and immune cells form a dynamic network that drives ...
Xiao Liu, Xiao Liu, Dandan Wang, Dandan Wang, Xue Cheng, Xue Cheng, Yining Ma, Yining Ma, Siya Li, Jinhai Deng, Chunyan Qiao, Chunyan Qiao   +11 more
doaj   +1 more source

Dynamics of bone volume during a single event of targeted bone remodeling.

, 2013
Dynamics of bone volume during a single event of targeted bone remodeling.
Bruce P. Ayati (414570), Jason M. Graham (414569), James A. Martin (414572), Sarah A. Holstein (414571)   +3 more
core   +1 more source

Ultrasound‐Activatable Piezoelectric Hydrogel Reprograms Mitochondrial Epigenetics for Osteoarthritis Therapy via the mTOR/GATD3A Axis

Advanced Science, EarlyView.
An ultrasound‐activatable piezoelectric hydrogel reprograms chondrocyte mitochondrial epigenetics via the mTOR/GATD3A axis, clearing damaged mitochondria and alleviating osteoarthritis progression in both mouse models and human cartilage explants. ABSTRACT The avascular nature of cartilage hinders drug delivery for osteoarthritis (OA) therapy.
Hui Zheng, Pengfei Yan, Peng Liu, Chang Yan, Mengqi Zhao, Zuyong Wang, Chao Ma, Rongkai Zhang, Xi Cui, Swee Hin Teoh   +9 more
wiley   +1 more source

Cell membrane biomimetic nanoplatforms: a new strategy for immune escape and precision targeted therapy

Materials Today Bio
Cell membrane biomimetic nanoplatforms represent an innovative approach to addressing key challenges in nanodrug delivery systems by encapsulating natural cell membranes onto nanomaterials. This strategy confers unique biological properties that overcome
Jian Feng, Dixin He, Jingxia Chen, Mucong Li, Jiaxin Luo, Yuzhu Han, Xuyan Wei, Sicong Ren, Zhibo Wang, Yunxiao Wu, Hanchi Wang, Yidi Zhang, Yanmin Zhou   +12 more
doaj   +1 more source

A Rare De Novo Missense Mutation in IFT122 Confers a Genetic Susceptibility Factor of Idiopathic Pediatric Uveitis Via Trio‐based Whole‐Exome Sequencing

Advanced Science, EarlyView.
A rare de novo IFT122‐A773E variant is identified in idiopathic pediatric uveitis and shown to exacerbate retinal inflammation and barrier dysfunction. Mechanistically, the variant enhances IFT43 interaction, elevates calcium signaling, and activates the MEK/ERK/FRA1 axis, revealing a previously unrecognized cilia‐associated pathway that may increase ...
Qian Zhou, Jiaxing Huang, Yilin Wang, Xingran Li, Xianyang Liu, Lingyu Dai, Hongshun Li, Qingfeng Wang, Jiangyi Liu, Guannan Su, Wanyun Zhang, Yang Deng, Qingfeng Cao, Yujie Lai, Xiang Luo, Changwei Huang, Ling Chen, Shengping Hou, Peizeng Yang   +18 more
wiley   +1 more source

Energy-harvesting conductive materials: a material-structure synergy framework for self-powered chronic wound healing

Materials & Design
Chronic wounds, especially diabetic ulcers, are sustained by persistent inflammation, infection, impaired angiogenesis, delayed re-epithelialization, extracellular matrix dysregulation, and metabolic imbalance.
Zhibo Wang, Jian Feng, Yuzhu Han, Yunxiao Wu, Liangqi Zhang, Jiameng Zhang, Boying Xiao, Jiaxin Luo, Hanchi Wang, Yanmin Zhou   +9 more
doaj   +1 more source

Effects of Optical Radiation on the Healing of Bone Defect in Rabbits

Hypothesis, that optical radiation is able to alter surface electrochemical potential and due to this affect bone remodeling processes have been proposed.
Ozolanta, Iveta, Kataševs, Aleksejs, Katasheva, Julia, Dehtjars, Jurijs   +3 more
core  

Machine Learning‐Driven Design of Multicomponent Bone Inorganic Matrix Mimicking Scaffolds for Osteogenesis Enhanced by Neurogenesis

Advanced Science, EarlyView.
Schematic illustration of development of experimental datasets and algorithm models, screening and preparation of the scaffolds and their applications in vivo. ABSTRACT Bone defects require materials with osteogenic, neurogenic, and angiogenic activity, yet designing such materials within high‐dimensional compositional spaces remains challenging. Here,
Kunlu Lin, Ying Yang, Chuyao Zhou, Hanyue Mao, Zhiquan Zhang, Libangxi Liu, Xiaoying Yu, Haoming Liu, Long Liu, Xiaoyan Wang   +9 more
wiley   +1 more source

Regulating Cells Fate and Function to Facilitate Bone Regeneration via Designing Programmable Bio‐Interactive Materials

Advanced Science, EarlyView.
This article aims to elucidate the biological mechanisms of bone repair and the evolution of material design, highlighting key cellular and molecular processes. It further proposes strategies and prospects for programmable bio‐interactive materials, which enable precisely guided bone tissue regeneration by dynamically regulating cell behavior and the ...
Qingrui Fan, Fuming Cao, Junqiang Mao, Pengbin Yin, Licheng Zhang, Jianjun Wang, Peifu Tang   +6 more
wiley   +1 more source