Results 121 to 130 of about 1,336,774 (305)

Bone Tissue Remodeling Features in Patients with Systemic Lupus Erythematosus Depending on the Degree of Bone Tissue Mineral Density Reduction

, 2014
Introduction. Osteoporosis is a systemic disease of the skeleton characterized by a decrease in bone mass and a violation of the microarchitectonics of bone tissue, which leads to increased bone fragility and fractures.
Abrahamovych U.
core   +1 more source

Targeted Restoration of the Microbial Tryptophan Oxidative Pathway Ameliorates Autism‐Like Behavioral and Synaptic Deficits

Advanced Science, EarlyView.
ABSTRACT Autism Spectrum Disorder (ASD) is associated with gut microbiota dysbiosis, yet the contribution of specific microbial metabolic pathways remains unclear. Reanalysis of a public ASD cohort revealed reduced functional potential in microbial tryptophan oxidative metabolism.
Rui Guo, Caian He, Xiao Xiao, Jingmeng Li, Zilong Zhang, Ying He, Chuanchuan Wang, Jiale Zhao, Jun Gong, Jiarui Liang, Tian Yuan, Haiting Sun, Xuebo Liu, Chao Gao, Zhigang Liu   +14 more
wiley   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Mesalazine: a novel therapeutic agent for periodontitis via regulation of periodontal microbiota and inhibiting Porphyromonas gingivalis

Frontiers in Microbiology
IntroductionPeriodontitis and inflammatory bowel disease are chronic inflammatory diseases with shared epidemiological, biological, and therapeutic associations. Given the similarities in their pathogenic factors, this study hypothesized that mesalazine,
Yuqi Wang, Yuqi Wang, Jun Ma, Haoyu Wang, Haoyu Wang, Jingzheng Yi, Yuxin Bai, Yuxin Bai, Min Hu, Min Hu, Jiaqing Yan, Jiaqing Yan   +11 more
doaj   +1 more source

A Clinical Study of Decellularized Tissue Engineering Hyaline Cartilage Graft (dLhCG) for Articular Cartilage Repair

Advanced Science, EarlyView.
ABSTRACT Current clinical approaches for knee cartilage repair are often limited by hypertrophy and fibrosis in the regenerated tissues. A decellularized tissue‐engineered hyaline cartilage graft (dLhCG), composed of a type II collagen‐based extracellular matrix, has been developed to overcome this limitation.
Zhen Zhang, Gong Cheng, Wenyong Fei, Qiuzhen Liang, Liang Zhang, Kegui Liu, Jihang Dai, Bo Cong, Xu Hu, Zhonglian Wu, Jialu Zhang, Jinlan Cui, Hang Yao, Dong‐An Wang, Jingcheng Wang, Tao Sun, Jiang Zheng   +16 more
wiley   +1 more source

Lactiplantibacillus Plantarum GUANKE Alleviates Allergic Asthma by Restricting Monocyte‐to‐DC Differentiation Via Microbiota‐Associated IAA

Advanced Science, EarlyView.
Lactiplantibacillus plantarum GUANKE remodels the indigenous gut microbiota and is associated with microbiota‐dependent restoration of circulating IAA. IAA treatment attenuates JAK3‐STAT3 and Jag1‐Notch4‐Hey1 signaling and reduces CX3CR1+Ly6C− monocytic precursor generation and pulmonary CD11b+ DC accumulation, together with reduced Th2 inflammation ...
Yujia He, Jielan Mi, Zhiping Zhao, Xiao Zhang, Zhihan Yang, Kun Yue, Yuanming Huang, Liqiong Song, Xiaoting Wen, Jianguo Xu, Zhihong Ren   +10 more
wiley   +1 more source

Functional Disorder at the Neural Interface: How Disordered Nanostructures Promote Proper Growth and Differentiation in In Vitro Neural Cultures

Advanced Science, EarlyView.
This work provides a practical guide for neuroengineers to design advanced neural interfaces, embracing and tailoring the concept of functional disorder. By bridging 2D and 3D in vitro models, this work highlights how non‐periodic, spatially heterogeneous, multiscale nanotopography can enable more physiologically relevant platforms for studying neural ...
F. Maita, E. Palmieri, I. Lucarini, L. Montaina, L. Maiolo   +4 more
wiley   +1 more source

Precise management of thick skin flaps after mandibular fibula muscle flap transplantation and implant restoration: a case report

Frontiers in Oral Health
Implant-supported restorations are critical for rehabilitating jawbone defects and restoring patients' occlusal function. Achieving proper fit and occlusal relationship with opposing teeth, as well as establishing a healthy peri-implant soft tissue seal,
Zhen Ci, Zhen Ci, Jingxia Chen, Jingxia Chen, Jiaxin Luo, Jiaxin Luo, Chuqiao Wei, Chuqiao Wei, Jian Feng, Jian Feng, Hanchi Wang, Hanchi Wang, Yanmin Zhou, Yanmin Zhou   +13 more
doaj   +1 more source

Harnessing Phase Separation for the Development of High‐Performance Hydrogels

Advanced Science, EarlyView.
ABSTRACT Hydrogels are indispensable for the development of next‐generation bioelectronics, soft robotics, and biomedical devices, where their mechanical properties determine performance and reliability. Among strategies to enhance hydrogel mechanics, phase separation enables controlled heterogeneity resulting in gel networks that are reinforced by ...
Yue Shao, Yiming Ma, Baihao Shao, Molly M. Stevens   +3 more
wiley   +1 more source

Bioceramic bone tissue-engineered substitutes with anti-inflammatory effects in periodontitis

Frontiers in Bioengineering and Biotechnology
Periodontitis is a chronic inflammatory oral disease characterized by irreversible alveolar bone resorption, which severely impairs oral health and even leads to tooth loss.
Boying Xiao, Boying Xiao, Yuzhu Han, Yuzhu Han, Chuqiao Wei, Chuqiao Wei, Yangfan Pei, Yangfan Pei, Yunxiao Wu, Yunxiao Wu, Zhibo Wang, Zhibo Wang, Hanchi Wang, Hanchi Wang, Yanmin Zhou, Yanmin Zhou   +15 more
doaj   +1 more source