Results 111 to 120 of about 1,336,774 (305)

Knee loading protects against osteonecrosis of the femoral head by enhancing vessel remodeling and bone healing

, 2015
Osteonecrosis of the femoral head is a serious orthopedic problem. Moderate loads with knee loading promote bone formation, but their effects on osteonecrosis have not been investigated.
Liu, Daquan, Li, Xinle, Li, Jie, Yokota, Hiroki, Yang, Jing, Zhang, Ping   +5 more
core   +1 more source

Extrusion‐Based Bioprinting of Living Bioinks for Tissue and Organ Engineering

Advanced Materials Technologies, EarlyView.
Extrusion‐based bioprinting is presented as the most versatile route for fabricating living, heterogeneous tissues. Its ability to combine diverse bioinks, support matrices, and advanced printhead geometries transforms familiar constraints into powerful biofabrication opportunities.
Eric Silberman, Ester Sapir Baruch, Roni Cohen, Assaf Shapira, Tal Dvir   +4 more
wiley   +1 more source

Prevention of bone loss during 56 days of strict bed rest by side-alternating resistive vibration exercise [PDF]

, 2010
Bed rest is a recognized model for muscle atrophy and bone loss in space flight and in clinical medicine. We hypothesized that whole body vibration in combination with resistive exercise (RVE) would be an effective countermeasure.
Schubert, Harald, Gast, Ulf, Beller, G., Stegeman, Dick F., Stegeman, D.F., Schiessl, Hans, Mulder, Edwin, de Haan, A., Felsenberg, D., de Haan, Arnold, Armbrecht, G., Buehring, Björn, Haan, A. de, Rittweger, J., Rittweger, Jörn, Buehring, B., Armbrecht, Gabriele, Mulder, E., Schiessl, H., Gast, U., Beller, Gisela, Mulder, Edwin R., Dimeo, Fernando C., Schubert, H., Dimeo, F., Felsenberg, Dieter, Dimeo, Fernando, Fernando Dimeo, Gisela Beller, Hans Schiessl, Jörn Rittweger, Edwin Mulder, Dick F. Stegeman, Ulf Gast, Arnold de Haan, Harald Schubert, Gabriele Armbrecht, Björn Buehring, Dieter Felsenberg   +38 more
core   +1 more source

Combating Inflammation and Promoting Anabolism in Osteoarthritic Cartilage Defect With an MMP13‐Sensing Dual‐Drug Scaffold

Advanced Science, EarlyView.
ABSTRACT Osteoarthritis (OA) is a widespread degenerative joint condition marked by progressive cartilage breakdown, and a chronic inflammatory microenvironment, where conventional therapies largely fail to halt disease progression. To address this unmet need, an intra‐articularly implantable, disease‐responsive scaffold was developed for combinatorial
Zhen Zhang, Bangheng Liu, Yulei Mu, Huiqun Zhou, Liang Ma, Chenjie Xu, Dong‐An Wang   +6 more
wiley   +1 more source

Research progress on the regulation and mechanism of osteocytes on osteoblasts and osteoclasts

Kouqiang hemian waike zazhi
With the continuous explorations and researches of osteocytes, osteocytes are no longer mistaken for a kind of quiescent and passive cells, but active and positive cells, which play important regulatory roles in osteoblasts and osteoclasts.
YANG Zhenming, ZHANG Shuyu, QIANG Jinbiao, SHI Yan, WANG Xiaoling, SHI Ce   +5 more
doaj   +1 more source

BAP31 Drives Cartilage Calcification through Disruption of Autophagosome–Lysosome Fusion in Osteoarthritis

Advanced Science, EarlyView.
Mechanical stress activates BAP31 in chondrocytes. BAP31 competes with ATG14 for binding to STX17, disrupting the STX17–ATG14 complex required for autophagosome–lysosome fusion. The resultant autophagic flux blockade drives the generation of autophagy‐derived exosomes, which mediate pathological cartilage calcification in OA. Chondrocyte‐targeted BAP31
Zhi‐hua Xu, Ruo‐xin Wang, Feng He, Qian Liu, Fu‐yin Li, Min Hui, Yu‐qian Shi, Yu Jiang, Qing‐hua Li, Jun‐wen Jing, Shi‐bin Yu, Li‐tian Ma, Qian‐nan Niu, Mian Zhang   +13 more
wiley   +1 more source

Osteogenic mechanism of chlorogenic acid and its application in clinical practice

Frontiers in Pharmacology
Natural polyphenols may have a role in counteracting oxidative stress, which is associated with aging and several bone-related diseases. Chlorogenic acid (CGA) is a naturally occurring polyphenolic compound formed by the esterification of caffeic and ...
Jiayu Shen, Jiayu Shen, Shichen Zhang, Shichen Zhang, Jiayu Zhang, Jiayu Zhang, Xin Wei, Xin Wei, Zilin Wang, Zilin Wang, Bing Han, Bing Han   +11 more
doaj   +1 more source

Densitometric evaluation of periprosthetic bone remodeling

, 2014
The application of Dual-energy X-ray absorptiometry (DEXA) in orthopaedic surgery gradually has been ex- tended from the study of osteoporosis to different areas of interest like the study of the relation between bone and prosthetic implants. Aim of this
ANDREANI, LORENZO, POGGETTI, ANDREA, Gianluca Ciapini, Iacopo Castellini, PIOLANTI, NICOLA, LISANTI, MICHELE, Valentina Cervi, PARCHI, PAOLO DOMENICO   +7 more
core  

An Adipocyte MKK3–p38β Axis Preserves Insulin Responsiveness in Mice and Is Reciprocally Altered in Human Obesity

Advanced Science, EarlyView.
The adipocyte MKK3–p38β axis emerges as an adaptive stress‐response pathway during obesity. Human visceral adipose tissue analyses, adipocyte‐specific mouse models, and primary adipocytes show that the MKK3–p38β axis supports insulin responsiveness by restraining p70S6K‐dependent inhibitory IRS1 feedback and preserving AKT–GLUT4 signaling. This pathway
Edgar Bernardo, Nuria Matesanz, Jorge‐Luis Torres, Alba C. Arcones, Juan Ignacio Jiménez‐Loygorri, Alfonso Mora, Leticia Herrera‐Melle, Luis Leiva‐Vega, Maria Elena Rodriguez, Lourdes Hernández‐Cosido, Marta Leon, Paula Yong González, Teresa Durán, Tamara Parracho, Francisca Mulero, Rubén Nogueiras, J. Simon C. Arthur, Angel R. Nebreda, Roger J. Davis, Miguel Marcos, Guadalupe Sabio   +20 more
wiley   +1 more source

Pre‐Regenerative Endothelial Cells Empowered by Antler Blood Exosomes Orchestrate Peripheral Nerve Repair

Advanced Science, EarlyView.
The pre‐regenerative vascular niche (PVN) is essential for nerve repair, yet its endothelial blueprint remains unclear. We identified angiogenic ECs (AECs) as the dominant pre‐regenerative subset and found that antler blood–derived exosomes (AB‐EXO) promote repair via IMP3.
Jinsheng Huang, Qiang Chen, Aihua Jin, Xiaoqi Yang, Hui Zhou, Weiquan Gong, Jin Cheng, Jun Dai, Minjin Wang, Meihua Piao, Yuanyi Wang, Nan Zhou   +11 more
wiley   +1 more source