Results 101 to 110 of about 217,854 (311)

A review of mathematical modeling of bone remodeling from a systems biology perspective

Bone remodeling is an essential physiological process in the adult skeleton. Due to the complex nature of this process, many mathematical models of bone remodeling have been developed.
Carley V., Cook, Ashlee N., Ford Versypt, Brenda J., Smith, Ariel M., Lighty   +3 more
core   +1 more source

Tissue-specific calibration of extracellular matrix material properties by transforming growth factor-beta and Runx2 in bone is required for hearing

, 2010
Publisher version: http://www.nature.com/embor/journal/v11/n10/full/embor2010135.htmlDA - 20100917 IS - 1469-3178 (Electronic) IS - 1469-221X (Linking) LA - ENG PT - JOURNAL ARTICLEDA - 20100917 IS - 1469-3178 (Electronic) IS - 1469-221X (Linking) LA ...
Anil Lalwani, Chin, EN, Carol G Chen, Derynck, R, Marshall, GW, Butcher, K, Guive Balooch, Lawrence Lustig, Akil, O, Porter, AE, Robert O Ritchie, Grayson W Marshall, Jacob Johnson, Lalwani, A, Sally J Marshall, Omar Akil, Emily N Chin, Balooch, G, Humphrey, MB, Lustig, L, Delia S Brauer, Rik Derynck, Kristin Butcher, Marshall, SJ, Richard A Schneider, Tamara Alliston, Alliston, T, Chen, CG, Johnson, J, Jolie L Chang, Brauer, DS, Alexandra E Porter, Schneider, RA, Chang, JL, Ritchie, RO, Mary Beth Humphrey   +35 more
core   +1 more source

Design and Synthesis of Peptide‐Polyester Conjugates for Cell‐Mediated Scaffold Degradation

Advanced Healthcare Materials, EarlyView.
This work describes polycaprolactone (PCL)‐based biomaterials engineered to degrade in response to cell‐secreted proteases. A fast‐degrading peptide (Fast) sequence is integrated into a PCL conjugate backbone to produce a biomaterial that is selectively degraded by multiple cell types compared to its scrambled control (ScrFast).
Korina Vida G. Sinad, Natasha K. Hunt, Srujan Singh, Kelly B. Seims, Yingjie Wu, E. Thomas Pashuck, Warren L. Grayson, Lesley W. Chow   +7 more
wiley   +1 more source

Advances in amino acid metabolism in bone remodeling and osteoporosis

Kouqiang hemian waike zazhi
Bone is a metabolically active organ that undergoes continuous bone remodeling throughout life to maintain bone homeostasis. Amino acids are the basic units of proteins, which play an important role in the regulation of material metabolism and ...
ZHANG Shuyu, YANG Zhenming, QIANG Jinbiao, SHI Ce   +3 more
doaj   +1 more source

Packed for Ossification: High‐Density Bioprinting of hPDC Spheroids in HAMA Toward Endochondral Ossification

Advanced Healthcare Materials, EarlyView.
Human periosteum‐derived cell spheroids bioprinted at high density within a hyaluronic acid matrix promote fusion and hypertrophic cartilage formation in vitro. Early encapsulation enhances spheroid interaction and matrix maturation, generating scalable cartilage templates intended for endochondral bone regeneration.
Ane Albillos Sanchez, Maria Paula Marks, Paula Casademunt, Adrián Seijas‐Gamardo, Ioannis Papantoniou, Lorenzo Moroni, Carlos Mota   +6 more
wiley   +1 more source

Targeted Regeneration of Bone in the Osteoporotic Human Femur

, 2011
We have recently developed image processing techniques for measuring the cortical thicknesses of skeletal structures in vivo, with resolution surpassing that of the underlying computed tomography system.
Gerard R. Ridgway, Poole, KES, Kenneth E. S. Poole, Borggrefe, J, Paul M Mayhew, Treece, GM, Ridgway, GR, Paul M. Mayhew, Andrew H. Gee, Graham M Treece, Mayhew, PM, Gee, AH, Graham M. Treece, Andrew H Gee, Gerard R Ridgway, Jan Borggrefe, Kenneth E S Poole   +16 more
core   +1 more source

A Fully Human Engineered Bone Niche With Endogenous Osteoclastogenesis Reveals Osteoclast‐Dependent Osteomimicry in Prostate Cancer Cells

Advanced Healthcare Materials, EarlyView.
A human 3D bone niche integrating osteoblasts and osteoclasts enables co‐culture with prostate cancer cell lines and patient‐derived organoids. The engineered niche (i) models aspects of reciprocal phenotypic regulation between osteoblasts and cancer cells, (ii) captures osteoclast‐enhanced osteomimicry in tumor cells, and (iii) establishes a ...
Andrea Mazzoleni, Robin Dolgos, Thomas Menter, Boris Dasen, Arnaud Scherberich, Clémentine Le Magnen, Manuele G. Muraro, Ivan Martin   +7 more
wiley   +1 more source

Influence of the mechanical environment upon the healing of segmental bone defects in the rat femur [PDF]

Loss of large segments of bone creates critical size defects (CSDs). These fail to heal spontaneously and present major clinical challenges to orthopaedic surgeons. The research described in this thesis is based upon the hypothesis that the healing of
Glatt, Vaida
core  

A Systematic Study of GelMA‐Carbopol Bioinks for High‐Fidelity Extrusion 3D Bioprinting at Physiological Temperatures

Advanced Healthcare Materials, EarlyView.
Gonzalez Martinez and collaborators develop a strategy to formulate high performance GelMA‐based bioinks with low solids contents. The resulting bioinks enable 3D bioprinting at 37 °C of high‐fidelity structures with tunable mechanical properties that support high cell viability and function.
David A. González‐Martínez, Aidee V. Arizpe Tafoya, Eduardo González‐Martínez, Mabel Barreiro Carpio, Laura Daniela Serrano Andrade, Christopher T. N. Chow, Mohammadhossein Dabaghi, Jeremy A. Hirota, Jose M. Moran‐Mirabal   +8 more
wiley   +1 more source

Polymorphisms in genes involved in the NF-κB signalling pathway are associated with bone mineral density, geometry and turnover in men [PDF]

, 2011
<p><b>Introduction:</b> In this study, we aimed to investigate the association between single nucleotide polymorphisms (SNPs) within two genes involved in the NF-kappa B cascade (GPR177 and MAP3K14) and bone mineral density (BMD ...
Wu, Frederick C., O'Neill Terence W., Wu Frederick C., Pendleton Neil, Casanueva, Felipe F., Judith E. Adams, Giwercman, Aleksander, Vanderschueren, Dirk, Holliday, Kate L., Frederick C Wu, Boonen, Steven, Thang S Han, Bartfai, G., Gyorgy Bartfai, Giwercman Aleksander, Ilpo T Huhtaniemi, Terence W. O'Neill, Punab Margus, Adams, J.E., null null, Pendleton, Neil, Pye Stephen R., Kate L. Holliday, Boonen, S., Han, T.S., Michael E. Lean, Holliday, K.L., Stephen R Pye, Huhtaniemi, Ilpo T., Lean, M.E., Dirk Vanderschueren, Adams, Judith E., Margus Punab, Borghs Herman, Felipe F. Casanueva, Judith E Adams, Lean Michael E., Wu, F.C., Herman Borghs, Kula, K., Forti, Gianni, Punab, Margus, Lean, Michael E., Finn, Joseph D., EMAS Study Group, O'Neill, T.W., Finn, J.D., Borghs, Herman, Kula Krzysztof, Joseph D Finn, Thomson, W., Delnaz Roshandel, Huhtaniemi, I.T., Stephen R. Pye, Terence W O'Neill, Giwercman, A., Holliday Kate L., Punab, M., Ward, Kate A., Neil Pendleton, Pye, Stephen R., Casanueva, F.F., Roshandel, Delnaz, Forti Gianni, Kula, Krzysztof, Casanueva Felipe F., Krzysztof Kula, O'Neill, Terence W., Borghs, H., Thang S. Han, Frederick C. Wu, Boonen Steven, Huhtaniemi Ilpo T., Casanueva Freijo, Felipe, Vanderschueren, D., Pendleton, N., Vanderschueren Dirk, Ward, K.A., Forti, G., Han, Thang S., Kate A Ward, Pye, S.R., Ward Kate A., Aleksander Giwercman, Han Thang S., Finn Joseph D., Gianni Forti, Steven Boonen, Bartfai, Gyorgy, Roshandel, D., Adams Judith E., Kate L Holliday, Kate A. Ward, Thomson Wendy, Bartfai Gyorgy, Michael E Lean, Wendy Thomson, Ilpo T. Huhtaniemi, Thomson, Wendy, Joseph D. Finn, Felipe F Casanueva, Roshandel Delnaz   +101 more
core   +1 more source