Results 11 to 20 of about 2,247,449 (357)

Overexpression of the Ubiquitin Specific Proteases USP43, USP41, USP27x and USP6 in Osteosarcoma Cell Lines: Inhibition of Osteosarcoma Tumor Growth and Lung Metastasis Development by the USP Antagonist PR619

open access: yesCells, 2021
Osteosarcoma (OS) is the most common malignant bone tumor in children and teenagers. In many cases, such as poor response to treatment or the presence of metastases at diagnosis, the survival rate of patients remains very low. Although in the literature,
Mélanie Lavaud   +14 more
doaj   +1 more source

The effect of cytokines on osteoblasts and osteoclasts in bone remodeling in osteoporosis: a review

open access: yesFrontiers in Immunology, 2023
The complicated connections and cross talk between the skeletal system and the immune system are attracting more attention, which is developing into the field of Osteoimmunology.
Jie Xu,   +4 more
semanticscholar   +1 more source

Modulation of bone remodeling by the gut microbiota: a new therapy for osteoporosis

open access: yesBone Research, 2023
The gut microbiota (GM) plays a crucial role in maintaining the overall health and well-being of the host. Recent studies have demonstrated that the GM may significantly influence bone metabolism and degenerative skeletal diseases, such as osteoporosis ...
Zhengtian Lyu   +3 more
semanticscholar   +1 more source

Macrophages and Bone Remodeling

open access: yesJournal of Bone and Mineral Research, 2023
Bone remodeling in the adult skeleton facilitates the removal and replacement of damaged and old bone to maintain bone quality. Tight coordination of bone resorption and bone formation during remodeling crucially maintains skeletal mass.
Megan M. Weivoda, E. Bradley
semanticscholar   +1 more source

Mechanical regulation of bone remodeling

open access: yesBone Research, 2022
Bone remodeling is a lifelong process that gives rise to a mature, dynamic bone structure via a balance between bone formation by osteoblasts and resorption by osteoclasts.
Lijun Wang   +4 more
semanticscholar   +1 more source

Bone remodeling: an operational process ensuring survival and bone mechanical competence

open access: yesBone Research, 2022
Bone remodeling replaces old and damaged bone with new bone through a sequence of cellular events occurring on the same surface without any change in bone shape.
S. Bolamperti, I. Villa, A. Rubinacci
semanticscholar   +1 more source

Roles of osteoclasts in alveolar bone remodeling

open access: yesGenesis, 2022
Osteoclasts are large multinucleated cells from hematopoietic origin and are responsible for bone resorption. A balance between osteoclastic bone resorption and osteoblastic bone formation is critical to maintain bone homeostasis. The alveolar bone, also
Maiko Omi, Y. Mishina
semanticscholar   +1 more source

LIM Kinases in Osteosarcoma Development

open access: yesCells, 2021
Tumorigenesis is a long-term and multistage process that often leads to the formation of metastases. During this pathological course, two major events appear to be crucial: primary tumour growth and metastatic expansion. In this context, despite research
Régis Brion   +5 more
doaj   +1 more source

The Role Of BMPs in the Regulation of Osteoclasts Resorption and Bone Remodeling: From Experimental Models to Clinical Applications

open access: yesFrontiers in Immunology, 2022
In response to mechanical forces and the aging process, bone in the adult skeleton is continuously remodeled by a process in which old and damaged bone is removed by bone-resorbing osteoclasts and subsequently is replaced by new bone by bone-forming ...
T. Bordukalo-Nikšić   +2 more
semanticscholar   +1 more source

Pro-inflammatory effects of human apatite crystals extracted from patients suffering from calcific tendinopathy

open access: yesArthritis Research & Therapy, 2021
Background Calcific tendonitis of the rotator cuff is due to carbonated apatite deposits in the shoulder tendons. During the evolution of the disease, an acute inflammatory episode may occur leading to the disappearance of the calcification.
Julien Herman   +6 more
doaj   +1 more source

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