Results 11 to 20 of about 2,265,392 (399)
Frontiers in Immunology, 2022 In response to mechanical forces and the aging process, bone in the adult skeleton is continuously remodeled by a process in which old and damaged bone is removed by bone-resorbing osteoclasts and subsequently is replaced by new bone by bone-forming ...
T. Bordukalo-Nikšić +2 more
semanticscholar +1 more source
Subchondral Bone Remodeling: A Therapeutic Target for Osteoarthritis
Frontiers in Cell and Developmental Biology, 2021 There is emerging awareness that subchondral bone remodeling plays an important role in the development of osteoarthritis (OA). This review presents recent investigations on the cellular and molecular mechanism of subchondral bone remodeling, and ...
Xiaobo Zhu +4 more
semanticscholar +1 more source
The Role of Osteocytes in Targeted Bone Remodeling: A Mathematical Model [PDF]
, 2013 Until recently many studies of bone remodeling at the cellular level have focused on the behavior of mature osteoblasts and osteoclasts, and their respective precursor cells, with the role of osteocytes and bone lining cells left largely unexplored. This
Ayati, Bruce P. +3 more
core +6 more sources
Genetics and Epigenetics of Bone Remodeling and Metabolic Bone Diseases
International Journal of Molecular Sciences, 2022 Bone metabolism consists of a balance between bone formation and bone resorption, which is mediated by osteoblast and osteoclast activity, respectively.
L. Otòn-Gonzalez +9 more
semanticscholar +1 more source
Annals of the New York Academy of Sciences, 2006 Abstract: The skeleton is a metabolically active organ that undergoes continuous remodeling throughout life. Bone remodeling involves the removal of mineralized bone by osteoclasts followed by the formation of bone matrix through the osteoblasts that subsequently become mineralized.
Hadjidakis, D.J., Androulakis, I.I.
openaire +5 more sources
Autophagy in Bone Remodeling: A Regulator of Oxidative Stress
Frontiers in Endocrinology, 2022 Bone homeostasis involves bone formation and bone resorption, which are processes that maintain skeletal health. Oxidative stress is an independent risk factor, causing the dysfunction of bone homeostasis including osteoblast-induced osteogenesis and ...
Chenyu Zhu +5 more
semanticscholar +1 more source
Advances of exosomes in periodontitis treatment
Journal of Translational Medicine, 2022 Periodontitis is an inflammatory disease initiated by dysbiosis of the local microbial community. Periodontitis can result in destruction of tooth-supporting tissue; however, overactivation of the host immune response is the main reason for alveolar bone
Hongbing Lin +8 more
doaj +1 more source
Trabecular bone organoid model for studying the regulation of localized bone remodeling
Science Advances, 2021 A tissue-engineered model of the trabecular bone microenvironment elucidates spatiotemporal aspects of bone remodeling processes. Trabecular bone maintains physiological homeostasis and consistent structure and mass through repeated cycles of bone ...
Yongkuk Park +5 more
semanticscholar +1 more source
Osteoclast-derived apoptotic bodies couple bone resorption and formation in bone remodeling
Bone Research, 2021 Bone remodeling is precisely coordinated by bone resorption and formation. Apoptotic osteoclasts generate large amounts of apoptotic bodies (ABs) marking the end of the bone resorption phase, whereas the functions of osteoclast-derived ABs remain largely
Qinyu Ma +7 more
semanticscholar +1 more source
Cellular and molecular mediators of bone metastatic lesions [PDF]
, 2018 Bone is the preferential site of metastasis for breast and prostate tumor. Cancer cells establish a tight relationship with the host tissue, secreting factors that stimulate or inhibit bone cells, receiving signals generated from the bone remodeling ...
Battafarano, Giulia +3 more
core +5 more sources