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Annals of the New York Academy of Sciences, 2006 Abstract: The skeleton is a metabolically active organ that undergoes continuous remodeling throughout life. Bone remodeling involves the removal of mineralized bone by osteoclasts followed by the formation of bone matrix through the osteoblasts that subsequently become mineralized.
Hadjidakis, D.J., Androulakis, I.I.
exaly +7 more sources
Tiludronate and clodronate do not affect bone structure or remodeling kinetics over a 60 day randomized trial [PDF]
, 2018 Background Tiludronate and clodronate are FDA-approved bisphosphonate drug therapies for navicular disease in horses. Although clinical studies have determined their ability to reduce lameness associated with skeletal disorders in horses, data regarding
Gillett, Ashley N. +3 more
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Disorders of Bone Remodeling [PDF]
Annual Review of Pathology: Mechanisms of Disease, 2011 The skeleton provides mechanical support for stature and locomotion, protects vital organs, and controls mineral homeostasis. A healthy skeleton must be maintained by constant bone modeling to carry out these crucial functions throughout life. Bone remodeling involves the removal of old or damaged bone by osteoclasts (bone resorption) and the ...
Xu, Feng, Jay M, McDonald
openaire +4 more sources
The Role of Osteocytes in Targeted Bone Remodeling: A Mathematical Model [PDF]
, 2013 Until recently many studies of bone remodeling at the cellular level have focused on the behavior of mature osteoblasts and osteoclasts, and their respective precursor cells, with the role of osteocytes and bone lining cells left largely unexplored. This
Ayati, Bruce P. +3 more
core +10 more sources
Cells, 2021 Osteosarcoma (OS) is the most common malignant bone tumor in children and teenagers. In many cases, such as poor response to treatment or the presence of metastases at diagnosis, the survival rate of patients remains very low. Although in the literature,
Mélanie Lavaud +14 more
doaj +1 more source
Effects of material properties of femoral hip components on bone remodeling [PDF]
, 1992 Bone loss around femoral hip stems is one of the problems threatening the long-term fixation of uncemented stems. Many believe that this phenomenon is caused by reduced stresses in the bone (stress shielding).
Grootenboer, H.J. +2 more
core +14 more sources
LIM Kinases in Osteosarcoma Development
Cells, 2021 Tumorigenesis is a long-term and multistage process that often leads to the formation of metastases. During this pathological course, two major events appear to be crucial: primary tumour growth and metastatic expansion. In this context, despite research
Régis Brion +5 more
doaj +1 more source
Arthritis Research & Therapy, 2021 Background Calcific tendonitis of the rotator cuff is due to carbonated apatite deposits in the shoulder tendons. During the evolution of the disease, an acute inflammatory episode may occur leading to the disappearance of the calcification.
Julien Herman +6 more
doaj +1 more source
Advances of exosomes in periodontitis treatment
Journal of Translational Medicine, 2022 Periodontitis is an inflammatory disease initiated by dysbiosis of the local microbial community. Periodontitis can result in destruction of tooth-supporting tissue; however, overactivation of the host immune response is the main reason for alveolar bone
Hongbing Lin +8 more
doaj +1 more source
Cells, 2020 The formation of the skeleton occurs throughout the lives of vertebrates and is achieved through the balanced activities of two kinds of specialized bone cells: the bone-forming osteoblasts and the bone-resorbing osteoclasts. Impairment in the remodeling
Camille Jacques +6 more
doaj +1 more source