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Annals of the New York Academy of Sciences, 2006 Abstract: The skeleton is a metabolically active organ that undergoes continuous remodeling throughout life. Bone remodeling involves the removal of mineralized bone by osteoclasts followed by the formation of bone matrix through the osteoblasts that subsequently ...
Hadjidakis, D.J., Androulakis, I.I.
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Disorders of Bone Remodeling [PDF]
Annual Review of Pathology: Mechanisms of Disease, 2011 The skeleton provides mechanical support for stature and locomotion, protects vital organs, and controls mineral homeostasis. A healthy skeleton must be maintained by constant bone modeling to carry out these crucial functions throughout life. Bone remodeling involves the removal of old or damaged bone by osteoclasts (bone resorption) and the ...
Xu, Feng, Jay M, McDonald
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Epigenetics and Bone Remodeling [PDF]
Current Osteoporosis Reports, 2017 Bone remodeling is a diverse field of study with many direct clinical applications; past studies have implicated epigenetic alterations as key factors of both normal bone tissue development and function and diseases of pathologic bone remodeling. The purpose of this article is to review the most important recent advances that link epigenetic changes to
Ali, Husain, Matlock A, Jeffries
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SHH Signaling Pathway Drives Pediatric Bone Sarcoma Progression
Cells, 2020 Primary bone tumors can be divided into two classes, benign and malignant. Among the latter group, osteosarcoma and Ewing sarcoma are the most prevalent malignant primary bone tumors in children and adolescents.
Frédéric Lézot +4 more
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Frontiers in Bioengineering and Biotechnology, 2023 Dental caries is a chronic, progressive disease caused by plaque, influenced by multiple factors and can damage the hard tissues of the teeth. In severe cases, it can also lead to the onset and development of other oral diseases, seriously affecting ...
Shanlin Qu +7 more
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Ribosomopathies: New Therapeutic Perspectives
Cells, 2020 Ribosomopathies are a group of rare diseases in which genetic mutations cause defects in either ribosome biogenesis or function, given specific phenotypes.
Emilien Orgebin +6 more
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Frontiers in Nutrition, 2023 “Medicine food homology” (MFH) is a term with a lengthy history. It refers to the fact that a lot of traditional natural products have both culinary and therapeutic benefits.
Shanlin Qu +7 more
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Bone remodelling at a glance [PDF]
Journal of Cell Science, 2011 The bone remodelling cycle (see Poster panel “The bone remodelling cycle”) maintains the integrity of the skeleton through the balanced activities of its constituent cell types. These are the bone-forming osteoblast, a cell that produces the organic bone matrix and aids its mineralisation ([
Julie C, Crockett +4 more
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The Osteosarcoma Microenvironment: A Complex but Targetable Ecosystem
Cells, 2020 Osteosarcomas are the most frequent primary bone sarcomas, affecting mainly children, adolescents, and young adults, and with a second peak of incidence in elderly individuals.
Isabelle Corre +4 more
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Frontiers in Endocrinology, 2023 BackgroundDexamethasone (DEX) exerts anti-inflammatory and osteogenic effects. Hydroxyapatite is commonly used in bone repair due to its osteoconductivity, osseointegration, and osteogenesis induction. Hollow hydroxyapatite (HHAM) is often used as a drug
Xiaoli Liu +6 more
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