Results 71 to 80 of about 360,243 (347)

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

In Situ Valence Engineering of Copper Silicate Nanozymes with Enhanced Peroxidase‐Like Catalytic Activity for Oral Disease Detection

Advanced Science
As a series of attractive nanomaterials, nanozymes with great catalytic activity and specificity are well developed in the field of biosensors. Although promising, the lack of appropriate structural design strategy and limitation of sensing performance ...
Xiaocan Liu, Zhen Ding, Chengjing Xu, Jinming Zhang, Yufu Liu, Tianyan Chen, Shuang Dai, Xingfu Bao, Min Hu, Zhen Liu   +9 more
doaj   +1 more source

Osteocyte dysfunction promotes osteoarthritis through MMP13-dependent suppression of subchondral bone homeostasis. [PDF]

, 2019
Osteoarthritis (OA), long considered a primary disorder of articular cartilage, is commonly associated with subchondral bone sclerosis. However, the cellular mechanisms responsible for changes to subchondral bone in OA, and the extent to which these ...
Acevedo, Claire, Alliston, Tamara, Bailey, Karsyn N, Dang, Alexis, Fields, Aaron J, Fowler, Tristan W, Kaya, Serra, Kuo, Alfred C, Lotz, Jeffrey C, Mazur, Courtney M, Vail, Thomas P, Woo, Jonathon J, Yee, Cristal S   +12 more
core  

Materials for Biomedical Applications [PDF]

, 1998
This paper discusses two ceramic material systems for selective laser sintering (SLS) that are being developed for biomedical applications for use in repair of bone defects.
Aufdemorte, T. B., Barlow, J. W, Fox, W. C, Lee, G., Swain, L.D., Vail, N.K   +5 more
core   +1 more source

Innate Immune Reprogramming Mediated by Endogenous Retroelement Dysregulation Drives Multiple Sclerosis Progression

Annals of Clinical and Translational Neurology, EarlyView.
Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao, Qiu‐Ping Zhao, Run‐Yun Li, Wei Chen, Huan‐Huan Song, Wan‐Jin Chen, Ying Fu   +6 more
wiley   +1 more source

Transient Local Bone Remodeling Effects of rhBMP-2 in an Ovine Interbody Spine Fusion Model [PDF]

, 2016
Background: Recombinant human bone morphogenetic protein-2 (rhBMP-2) is a powerful osteoinductive morphogen capable of stimulating the migration of mesenchymal stem cells (MSCs) to the site of implantation and inducing the proliferation and ...
Badura, Jeffrey, Bae, Hyun W., Patel, Vikas V., Pradhan, Ben B., Sardar, Zeeshan M., Seim, Howard, Toth, Jeffrey M., Turner, Anthony S.   +7 more
core   +1 more source

Influence of cementless hip stems on femoral cortical strain pattern depending on their extent of porous coating [PDF]

, 2012
The extent of porous coating of cementless total hip stems is held responsible for radiological periprosthetic changes, the rate of thigh pain, and even its long-term success.
Bader, Rainer, Ellenrieder, Martin, Mittelmeier, Wolfram, Steinhauser, Erwin   +3 more
core   +1 more source

Biopsychosocial determinants of hand function and its trajectories over five years in patients with hand osteoarthritis

Arthritis Care &Research, Accepted Article.
Objectives This study aimed to investigate hand function trajectories over 5 years in primary hand osteoarthritis. Additionally, determinants of baseline and longitudinal hand function were assessed. Methods 538 patients with both baseline and 5‐year study visits were analyzed.
Annemiek V.E.M. Olde Meule, Coen van der Meulen, Jos Runhaar, Frits R. Rosendaal, Margreet Kloppenburg   +4 more
wiley   +1 more source