Results 71 to 80 of about 1,336,774 (305)

The clock genes Period 2 and Cryptochrome 2 differentially balance bone formation [PDF]

, 2010
Background: Clock genes and their protein products regulate circadian rhythms in mammals but have also been implicated in various physiological processes, including bone formation.
Maronde, E. (Erik), Amling, Michael, Schinke, T. (Thorsten), Schilling, A.F. (Arndt), Schinke Thorsten, Seitz, S. (Sebastian), Albrecht Urs, Arndt F Schilling, Amling Michael, Urs Albrecht, Maronde, Erik, Schmutz, I. (Isabelle), Maronde Erik, Isabelle Schmutz, Horst, Gijsbertus van der, Thorsten Schinke, Schmutz Isabelle, Seitz, Sebastian, Schilling, Arndt F., Schilling Arndt F., Arndt F. Schilling, Seitz Sebastian, Schilling, Arndt, Sebastian Seitz, Schinke, Thorsten, Albrecht, U. (Urs), Schmutz, Isabelle, Amling, M. (Michael), Erik Maronde, Albrecht, Urs, Horst, G.T.J. (Gijsbertus) van der, Gijsbertus van der Horst, Michael Amling, van der Horst Gijsbertus, van der Horst, Gijsbertus   +34 more
core   +1 more source

Cell surface CD11c as a neutrophil aging marker molecule

FEBS Open Bio, EarlyView.
Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki, Fahd Alhamdan, Erik Malm, Marie Bermudez, Samuel Y. Kim, Koichi Yuki   +5 more
wiley   +1 more source

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

FEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao, Leonie Meyer, Madita Braun, Katharina Otte, Celine Bitter, Maite Pawlik, Hartmann Raifer, Frederik Helmprobst, Axel Pagenstecher, Hans Urban, Michael C. Burger, Michael W. Ronellenfitsch, Joachim P. Steinbach, Jarmila Jedelská, Shamim Bagheri, Behrooz H. Yousefi, Pietro Di Fazio, Markus Luster, Andreas H. Mahnken, Andreas Neubauer, Andreas Burchert, Christopher Nimsky, Jörg W. Bartsch, Tillmann Rusch   +23 more
wiley   +1 more source

In Situ Valence Engineering of Copper Silicate Nanozymes with Enhanced Peroxidase‐Like Catalytic Activity for Oral Disease Detection

Advanced Science
As a series of attractive nanomaterials, nanozymes with great catalytic activity and specificity are well developed in the field of biosensors. Although promising, the lack of appropriate structural design strategy and limitation of sensing performance ...
Xiaocan Liu, Zhen Ding, Chengjing Xu, Jinming Zhang, Yufu Liu, Tianyan Chen, Shuang Dai, Xingfu Bao, Min Hu, Zhen Liu   +9 more
doaj   +1 more source

Cellular and molecular mechanisms of bone remodeling

, 2010
Physiological bone remodeling is a highly coordinated process responsible for bone resorption and formation and is necessary to repair damaged bone and to maintain mineral homeostasis.
Raggatt, Liza J., Partridge, Nicola C.
core   +1 more source

YAP and TAZ Mediate Osteocyte Perilacunar/Canalicular Remodeling

, 2020
Bone fragility fractures are caused by low bone mass or impaired bone quality. Osteoblast/osteoclast coordination determines bone mass, but the factors that control bone quality are poorly understood.
Boerckel, Joel D., Daniel J Horan, Virginia L Ferguson, Bellido, Teresita M., Jordan, Kelsey M., Alexander G Robling, Horan, Daniel J., Kegelman, Christopher D., Joel D Boerckel, Robling, Alexander G., Qin, Ling, Jennifer C Coulombe, Teresita M Bellido, Coulombe, Jennifer C., Ferguson, Virginia L., Kelsey M Jordan, Ling Qin, Christopher D Kegelman   +17 more
core   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Osteocyte-Driven Bone Remodeling [PDF]

, 2014
Osteocytes, the most abundant cells in bone, have been long postulated to detect and respond to mechanical and hormonal stimuli and to coordinate the function of osteoblasts and osteoclasts.
Bellido, Teresita
core   +1 more source

Bone‐Inspired Recyclable Composites for Damage‐Tolerant Circular Materials

Advanced Functional Materials, EarlyView.
Bone‐inspired architected composites are developed by combining osteon‐like reinforcements with a recyclable Elium thermoplastic matrix. The hierarchical architecture redirects cracks and promotes energy dissipation, while enabling recovery of intact, aligned, load‐bearing reinforcement units that retain their original stiffness, revealing a route ...
Alessandro Stagni, Nastaran Bahrami Novin, Luigi Benvenuto, Enrico Lertora, Flavia Libonati   +4 more
wiley   +1 more source

ATP-dependent chromatosome remodeling [PDF]

, 2008
Chromatin serves to package, protect and organize the complex eukaryotic genomes to assure their stable inheritance over many cell generations. At the same time, chromatin must be dynamic to allow continued use of DNA during a cell's lifetime.
Chioda, Mariacristina, Becker, Peter B., Maier, Verena K.   +2 more
core   +1 more source