Results 51 to 60 of about 217,854 (311)

Robots and Tools for Remodeling Bone

IEEE Reviews in Biomedical Engineering, 2020
The field of robotic surgery has progressed from small teams of researchers repurposing industrial robots, to a competitive and highly innovative subsection of the medical device industry. Surgical robots allow surgeons to perform tasks with greater ease, accuracy, or safety, and fall under one of four levels of autonomy; active, semi-active, passive ...
Dave Hill, Tom Williamson, Chow Yin Lai, Martin Leary, Milan Brandt   +4 more
openaire   +3 more sources

Contribution of atypical chemokine receptor 2/ackr2 in bone remodeling

, 2017
Introduction: Bone remodeling is a tightly regulated process influenced by chemokines. ACKR2 is a decoy receptor for CC chemokines functioning as regulator of inflammatory response.
Sandra Yasuyo Fukada, Remo Castro Russo, Angélica Cristina Fonseca, Tarcília Aparecida da Silva, Davidson Frois Madureira, Janine Mayra da Silva, Letícia Fernanda Duffles Rodrigues, Izabella Lucas de Abreu Lima, Gustavo Pompermaier Garlet, Mauro Martins Teixeira   +9 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Gallium and gallium compounds: New insights into the “Trojan horse” strategy in medical applications

Materials & Design, 2023
Infection, inflammation, tumors, and other illnesses have for a long time posed a major danger to human health and have developed into a global public health issue.
Wenyue Sun, Manlin Qi, Shi Cheng, Chunyan Li, Biao Dong, Lin Wang   +5 more
doaj   +1 more source

Prevention of bone loss during 56 days of strict bed rest by side-alternating resistive vibration exercise

, 2010
Bed rest is a recognized model for muscle atrophy and bone loss in space flight and in clinical medicine. We hypothesized that whole body vibration in combination with resistive exercise (RVE) would be an effective countermeasure.
Schubert, Harald, Gast, Ulf, Beller, G., Stegeman, Dick F., Stegeman, D.F., Schiessl, Hans, Mulder, Edwin, de Haan, A., Felsenberg, D., de Haan, Arnold, Armbrecht, G., Buehring, Björn, Haan, A. de, Rittweger, J., Rittweger, Jörn, Buehring, B., Armbrecht, Gabriele, Mulder, E., Schiessl, H., Gast, U., Beller, Gisela, Mulder, Edwin R., Dimeo, Fernando C., Schubert, H., Dimeo, F., Felsenberg, Dieter, Dimeo, Fernando   +26 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Regulation of FN1 degradation by the p62/SQSTM1-dependent autophagy–lysosome pathway in HNSCC

International Journal of Oral Science, 2020
Epithelial–mesenchymal transition (EMT) is involved in both physiological and pathological processes. EMT plays an essential role in the invasion, migration and metastasis of tumours.
Xinchen Liu, Lin Meng, Xing Li, Daowei Li, Qilin Liu, Yumeng Chen, Xiangwei Li, Wenhuan Bu, Hongchen Sun   +8 more
doaj   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Identification of cross-talk pathways and PANoptosis-related genes in periodontitis and Alzheimer’s disease by bioinformatics analysis and machine learning

Frontiers in Aging Neuroscience
Background and objectivesPeriodontitis (PD), a chronic inflammatory disease, is a serious threat to oral health and is one of the risk factors for Alzheimer’s disease (AD).
Xiantao Chen, Xiantao Chen, Yifei Dai, Yifei Dai, Yushen Li, Yushen Li, Jiajun Xin, Jiajun Xin, Jiatong Zou, Jiatong Zou, Rui Wang, Rui Wang, Hao Zhang, Hao Zhang, Zhihui Liu, Zhihui Liu   +15 more
doaj   +1 more source

Nanomaterials-mediated on-demand and precise antibacterial therapies

Materials & Design, 2023
Bacterial infection is a series of pathological changes caused by bacteria invading the host and interacting with the body. Nowadays, bacterial infection remains a major public health issue and a severe threat to human life and health.
Shi Cheng, Qihui Wang, Manlin Qi, Wenyue Sun, Kun Wang, Wen Li, Jinying Lin, Biao Dong, Lin Wang   +8 more
doaj   +1 more source