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Bio-Protocol, 2014 The Bone resorption assay provides an easy to use protocol for quantitatively measuring in vitro osteoclast-mediated bone resorption. Osteoclasts can be seeded onto the bone slices and formation of resorption pits can be quantified via toluidinblue ...
Carina Scholtysek +2 more
doaj +4 more sources
Mechanisms of Bone Resorption in Periodontitis [PDF]
Journal of Immunology Research, 2015 Alveolar bone loss is a hallmark of periodontitis progression and its prevention is a key clinical challenge in periodontal disease treatment. Bone destruction is mediated by the host immune and inflammatory response to the microbial challenge. However, the mechanisms by which the local immune response against periodontopathic bacteria disturbs the ...
Stefan A. Hienz +2 more
openaire +6 more sources
Roles of hyaluronan in bone resorption [PDF]
BMC Musculoskeletal Disorders, 2004 Background Hyaluronan, an unsulfated glycosaminoglycan, while being closely linked to osteoclast function several years ago, has received little attention lately. Given recent new knowledge of hyaluronan's possible cell binding abilities, it is important
Prince Charles W
doaj +4 more sources
Local mechanical stimuli regulate bone formation and resorption in mice at the tissue level. [PDF]
PLoS ONE, 2013 Bone is able to react to changing mechanical demands by adapting its internal microstructure through bone forming and resorbing cells. This process is called bone modeling and remodeling.
Friederike A Schulte +6 more
doaj +2 more sources
An In Vitro Model of Murine Osteoclast-Mediated Bone Resorption [PDF]
Bio-ProtocolOsteoclasts are terminally differentiated multinucleated giant cells that mediate bone resorption and regulate skeletal homeostasis under physiological and pathological states.
Xiaoyue Sun +4 more
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Osteoclast-derived apoptotic bodies couple bone resorption and formation in bone remodeling
Bone Research, 2021 Bone remodeling is precisely coordinated by bone resorption and formation. Apoptotic osteoclasts generate large amounts of apoptotic bodies (ABs) marking the end of the bone resorption phase, whereas the functions of osteoclast-derived ABs remain largely
Qinyu Ma +7 more
semanticscholar +1 more source
Relationship between the Height of Alveolar Bone Resorption and Sex and Age in Adolescents
Fayixue Zazhi, 2022 ObjectiveTo explore the relationship between the height of alveolar bone resorption and sex and age in the adolescent dentition.MethodsMulti-slice computed tomography （MSCT） was used to measure the height of alveolar bone resorption at labial, lingual ...
MA Jing-jing +7 more
doaj +1 more source
The Mechanism Switching the Osteoclast From Short to Long Duration Bone Resorption
Frontiers in Cell and Developmental Biology, 2021 The current models of osteoclastic bone resorption focus on immobile osteoclasts sitting on the bone surface and drilling a pit into the bone matrix.
Jean-Marie Delaisse +11 more
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Osteocyte-Related Cytokines Regulate Osteoclast Formation and Bone Resorption
International Journal of Molecular Sciences, 2020 The process of bone remodeling is the result of the regulated balance between bone cell populations, namely bone-forming osteoblasts, bone-resorbing osteoclasts, and the osteocyte, the mechanosensory cell type.
H. Kitaura +9 more
semanticscholar +1 more source
Science Translational Medicine, 2020 Independent of cathepsin K, the osteoclast-derived matrix metalloproteinases MMP9 and MMP14 codependently drive bone resorption. Codependent deconstruction Bone homeostasis encompasses a balancing act between formation of new bone and remodeling and ...
Lingxin Zhu +7 more
semanticscholar +1 more source