Investigation of bone resorption within a cortical basic multicellular unit using a lattice-based computational model [PDF]
Bone 50, 378-389 (2012), 2011 In this paper we develop a lattice-based computational model focused on bone resorption by osteoclasts in a single cortical basic multicellular unit (BMU). Our model takes into account the interaction of osteoclasts with the bone matrix, the interaction of osteoclasts with each other, the generation of osteoclasts from a growing blood vessel, and the ...
Anderson +74 more
arxiv +4 more sources
Control of bone resorption by semaphorin 4D is dependent on ovarian function. [PDF]
PLoS ONE, 2011 Osteoporosis is one of the most common bone pathologies, which are characterized by a decrease in bone mass. It is well established that bone mass, which results from a balanced bone formation and bone resorption, is regulated by many hormonal ...
Romain Dacquin +5 more
doaj +9 more sources
Bio-Protocol, 2014 The Bone resorption assay provides an easy to use protocol for quantitatively measuring in vitro osteoclast-mediated bone resorption. Osteoclasts can be seeded onto the bone slices and formation of resorption pits can be quantified via toluidinblue ...
Carina Scholtysek +2 more
doaj +2 more sources
Experimental model in vivo for quantitative assessment of bone resorption inhibition [PDF]
, 1993 Quantitative assessment of bone resorption inhibition in vivo is not easily accomplished; methods relying on a count of osteoclasts are questionable, and histomorphometric evaluation of the bone mass presents several technical problems as well.
Ugo E. Pazzaglia +4 more
openalex +3 more sources
P38 mitogen-activated protein kinase inhibitor, FR167653, inhibits parathyroid hormone related protein-induced osteoclastogenesis and bone resorption. [PDF]
PLoS ONE, 2011 p38 mitogen-activated protein kinase (MAPK) acts downstream in the signaling pathway that includes receptor activator of NF-κB (RANK), a powerful inducer of osteoclast formation and activation.
Huiren Tao +4 more
doaj +4 more sources
Sphingomyelinase and ceramide inhibit formation of F‐actin ring in and bone resorption by rabbit mature osteoclasts [PDF]
, 1998 Recent studies have demonstrated that ceramide plays an important role as a second messenger in many kinds of cells. However, it is not known whether apoptosis of and bone resorption by mature osteoclasts are mediated via sphingomyelinase (SMase) and ...
Hiroyuki Takeda +5 more
openalex +3 more sources
Local mechanical stimuli regulate bone formation and resorption in mice at the tissue level. [PDF]
PLoS ONE, 2013 Bone is able to react to changing mechanical demands by adapting its internal microstructure through bone forming and resorbing cells. This process is called bone modeling and remodeling.
Friederike A Schulte +6 more
doaj +2 more sources
Alterations in osteoclast function and phenotype induced by different inhibitors of bone resorption - implications for osteoclast quality [PDF]
BMC Musculoskeletal Disorders, 2010 Background Normal osteoclasts resorb bone by secretion of acid and proteases. Recent studies of patients with loss of function mutations affecting either of these processes have indicated a divergence in osteoclastic phenotypes.
Leeming Diana J +6 more
doaj +5 more sources
Roles of hyaluronan in bone resorption [PDF]
BMC Musculoskeletal Disorders, 2004 Background Hyaluronan, an unsulfated glycosaminoglycan, while being closely linked to osteoclast function several years ago, has received little attention lately. Given recent new knowledge of hyaluronan's possible cell binding abilities, it is important
Prince Charles W
doaj +4 more sources
Roles of Toll-like Receptor Signaling in Inflammatory Bone Resorption [PDF]
BiologyToll-like receptors (TLRs) are pattern recognition receptors expressed in immune cells, including neutrophils, macrophages, and dendritic cells. Microbe-associated molecular patterns, including bacterial components, membranes, nucleic acids, and flagella
Tsukasa Tominari +12 more
doaj +2 more sources