Results 91 to 100 of about 1,831,965 (356)
Physiologic osteoclasts are not sufficient to induce skeletal pain in mice [PDF]
, 2020 Background: Increased bone resorption is driven by augmented osteoclast activity in pathological states of the bone, including osteoporosis, fracture and metastatic bone cancer.
De Clauser, L +3 more
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BoneKEy Reports, 2014 The reversal phase couples bone resorption to bone formation by generating an osteogenic environment at remodeling sites. The coupling mechanism remains poorly understood, despite the identification of a number of ‘coupling' osteogenic molecules.
J. Delaissé
semanticscholar +1 more source
RANKL biology: bone metabolism, the immune system, and beyond
Inflammation and Regeneration, 2020 Receptor activator of NF-κB (RANK) ligand (RANKL) induces the differentiation of monocyte/macrophage–lineage cells into the bone–resorbing cells called osteoclasts.
T. Ono +3 more
semanticscholar +1 more source
Universal Hydrogel Carrier Enhances Bone Graft Success: Preclinical and Clinical Evaluation
Advanced Healthcare Materials, EarlyView.TX hydrogel improves the delivery of different types of particulate bone grafts, maintaining them at the implantation sites, and resulting in favorable bone regenerative outcomes. Abstract Orthopedic, maxillofacial, and complex dentoalveolar bone grafting procedures that require donor‐site bone harvesting can be associated with post‐surgical ...
Dax Calder +9 more
wiley +1 more source
Nature Communications, 2020 Anti-resorptive bone therapies also inhibit bone formation, as osteoclasts secrete factors that stimulate bone formation by osteoblasts. Here, the authors identify osteoclast-secreted factors that couple bone resorption to bone formation in healthy ...
Megan M. Weivoda +19 more
doaj +1 more source
Mechanical sensing protein PIEZO1 regulates bone homeostasis via osteoblast-osteoclast crosstalk
Nature Communications, 2020 Wolff’s law and the Utah Paradigm of skeletal physiology state that bone architecture adapts to mechanical loads. These models predict the existence of a mechanostat that links strain induced by mechanical forces to skeletal remodeling.
Lijun Wang +5 more
semanticscholar +1 more source
Advanced Healthcare Materials, EarlyView.NeoCast is a next‐generation, solvent‐free, non‐adhesive liquid embolic designed for indications where deep occlusion is desired (e.g., tumors and chronic subdural hematoma). This novel agent offers ideal embolic properties: injectability, controllability, excellent visibility, and biocompatibility.
Quynh P. Pham +16 more
wiley +1 more source
Journal of Pharmacological Sciences, 2006 .: Bone formation in adults determines the basic mass of bone and hence it is crucial to understand the mechanisms of its regulation. As remodeling is proceeding, bone resorption is determined by the physical conditions.
Masaki Noda
doaj
Endocortical bone loss in osteoporosis: The role of bone surface availability [PDF]
Int J Numer Meth Biomed Engng (2013) 29:1307-1322, 2012 Age-related bone loss and postmenopausal osteoporosis are disorders of bone remodelling, in which less bone is reformed than resorbed. Yet, this dysregulation of bone remodelling does not occur equally in all bone regions. Loss of bone is more pronounced near and at the endocortex, leading to cortical wall thinning and medullary cavity expansion, a ...
arxiv +1 more source
Strontium ranelate: A novel mode of action leading to renewed bone quality [PDF]
, 2018 Various bone resorption inhibitors and bone stimulators have been shown to decrease the risk of osteoporotic fractures. However, there is still a need for agents promoting bone formation by inducing positive uncoupling between bone formation and bone ...
Ammann, Patrick
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