Results 21 to 30 of about 1,847,810 (404)

Malignant melanoma and bone resorption [PDF]

British Journal of Cancer, 2006
The cellular and humoral mechanisms accounting for osteolysis in skeletal metastases of malignant melanoma are uncertain. Osteoclasts, the specialised multinucleated cells that carry out bone resorption, are derived from monocyte/macrophage precursors.
Lau, Y, Sabokbar, A, Giele, H, Cerundolo, V, Hofstetter, W, Athanasou, N   +5 more
openaire   +2 more sources

Three‐Dimensional Distribution of Bone‐Resorption Lesions in Osteonecrosis of the Femoral Head Based on the Three‐Pillar Classification

Orthopaedic Surgery, 2021
Objective To investigate three‐dimensional distribution of bone‐resorptive lesions based on the three‐pillar classification and its effect on the disease progression of osteonecrosis of the femoral head (ONFH).
Guang‐bo Liu, Qiang Lu, Hao‐ye Meng, Qi Quan, Yu‐xuan Zhang, Huo Li, Hai‐yang Ma, Jun Zhao, Peng Wang, Xue‐feng Zhou, Jiang Peng   +10 more
doaj   +1 more source

p38α MAPK regulates proliferation and differentiation of osteoclast progenitors and bone remodeling in an aging-dependent manner. [PDF]

, 2017
Bone mass is determined by the balance between bone formation, carried out by mesenchymal stem cell-derived osteoblasts, and bone resorption, carried out by monocyte-derived osteoclasts.
Ao, Junping, Cong, Qian, Jia, Hao, Li, Baojie, Li, Ping, Liu, Huijuan, Qiu, Shoutao, Wang, Yibin, Yeh, James, Zhang, Zhen-Lin   +9 more
core   +1 more source

Mechanisms of bone resorption

Bone, 2022
La résorption des tissus minéralisés comme l'os est accomplie par un type cellulaire unique : l'ostéoclaste. Cette cellule multinucléée a la capacité de dissoudre le minéral en abaissant le pH. Par la suite, la libération de certaines enzymes protéolytiques, en particulier la cathepsine K, entraîne la digestion de la matrice organique constituée ...
Vincent Everts, Ineke D.C. Jansen, Teun J. de Vries   +2 more
openaire   +4 more sources

Bone resorption goes green [PDF]

Cell, 2021
In this issue of Cell, McDonald et al. show that giant multinucleated, bone-resorbing osteoclasts dissolve into smaller cells, termed "osteopmorhs," which re-form into osteoclasts at distal bone sites (McDonald et al., 2021). These findings overturn the long-standing premise that osteoclasts differentiate solely from hematopoietic precursors and ...
Mone Zaidi, Jameel Iqbal, Jameel Iqbal
openaire   +3 more sources

Inhibited Maternal Bone Resorption Suppress Fetal Rat Bone Development During Pregnancy

Frontiers in Cell and Developmental Biology, 2020
ObjectiveTo determine the relationship between maternal bone resorption and bone development in fetuses.MethodsFemale SD rats were injected with either fluorescent calcium indicator calcein alone or together with tetracycline 1 week before pregnancy ...
Huanhuan Jia, Huanhuan Jia, Li Rao, Kai Kei Miu, Shuangjie Tang, Wei Chen, Guozhu Yang, Yuying Li, Qingnan Li, Qingnan Li, Jun Chen, Li Lu   +11 more
doaj   +1 more source

An $\textit{in vivo}$ comparison study between strontium nanoparticles and rhBMP2 [PDF]

Frontiers in Bioengineering and Biotechnology 2020;8:499, 2020
The osteoinductive property of strontium was repeatedly proven in the last decades. Compelling $\textit{in vitro}$ data demonstrated that strontium hydroxyapatite nanoparticles exert a dual action, by promoting osteoblasts-driven matrix secretion and inhibiting osteoclasts-driven matrix resorption. Recombinant human bone morphogenetic protein 2 (rhBMP2)
arxiv   +1 more source

Bone Resorption by Osteocytes

Experimental Biology and Medicine, 1968
SummaryOsteocyte lacunae were measured in normal rats and in rats in which periosteal hypertrophy had been induced at the adductor longus-pectineus insertion. Lacunae in the cortex beneath the periosteal hypertrophy were significantly larger than lacunae in the cortex of the opposite side of the femur from the hypertrophy.
J. F. Shea, J. J. Taylor, V. L. Yeager, J. J. Taylor   +3 more
openaire   +3 more sources

Nanotechnology and Dental Implants

International Journal of Biomaterials, 2010
The long-term clinical success of dental implants is related to their early osseointegration. This paper reviews the different steps of the interactions between biological fluids, cells, tissues, and surfaces of implants.
Sandrine Lavenus, Guy Louarn, Pierre Layrolle   +2 more
doaj   +1 more source

The Role of Calcium in Inflammation-Associated Bone Resorption

Biomolecules, 2018
The aim of this mini-review is to discuss the role of calcium in the process of cytokine-mediated bone resorption in an effort to understand the role circulating calcium may play in the resorption of bone.
Gordon L. Klein
doaj   +1 more source