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La résorption des tissus minéralisés comme l'os est accomplie par un type cellulaire unique : l'ostéoclaste. Cette cellule multinucléée a la capacité de dissoudre le minéral en abaissant le pH. Par la suite, la libération de certaines enzymes protéolytiques, en particulier la cathepsine K, entraîne la digestion de la matrice organique constituée ...
Vincent Everts+2 more
openaire +4 more sources
Bone matrix components activate the NLRP3 inflammasome and promote osteoclast differentiation [PDF]
The NLRP3 inflammasome senses a variety of signals referred to as danger associated molecular patterns (DAMPs), including those triggered by crystalline particulates or degradation products of extracellular matrix. Since some DAMPs confer tissue-specific
Abu-Amer, Yousef+9 more
core +2 more sources
SummaryOsteocyte lacunae were measured in normal rats and in rats in which periosteal hypertrophy had been induced at the adductor longus-pectineus insertion. Lacunae in the cortex beneath the periosteal hypertrophy were significantly larger than lacunae in the cortex of the opposite side of the femur from the hypertrophy.
J. F. Shea+3 more
openaire +3 more sources
Effects of material properties of femoral hip components on bone remodeling [PDF]
Bone loss around femoral hip stems is one of the problems threatening the long-term fixation of uncemented stems. Many believe that this phenomenon is caused by reduced stresses in the bone (stress shielding).
Grootenboer, H.J.+2 more
core +8 more sources
Nanotechnology and Dental Implants
The long-term clinical success of dental implants is related to their early osseointegration. This paper reviews the different steps of the interactions between biological fluids, cells, tissues, and surfaces of implants.
Sandrine Lavenus+2 more
doaj +1 more source
Resorption controls bone anabolism driven by PTH receptor signaling in osteocytes [PDF]
The contribution of remodeling-based bone formation coupled to osteoclast activity versus modeling-based bone formation that occurs independently of resorption, to the anabolic effect of PTH remains unclear.
Allen, Matthew R.+7 more
core +1 more source
The Role of Calcium in Inflammation-Associated Bone Resorption
The aim of this mini-review is to discuss the role of calcium in the process of cytokine-mediated bone resorption in an effort to understand the role circulating calcium may play in the resorption of bone.
Gordon L. Klein
doaj +1 more source
Bone resorption goes green [PDF]
In this issue of Cell, McDonald et al. show that giant multinucleated, bone-resorbing osteoclasts dissolve into smaller cells, termed "osteopmorhs," which re-form into osteoclasts at distal bone sites (McDonald et al., 2021). These findings overturn the long-standing premise that osteoclasts differentiate solely from hematopoietic precursors and ...
Mone Zaidi, Jameel Iqbal, Jameel Iqbal
openaire +3 more sources
Aplidin (plitidepsin) is a novel anti-myeloma agent with potent anti-resorptive activity mediated by direct effects on osteoclasts [PDF]
Despite recent progress in its treatment, Multiple Myeloma (MM) remains incurable and its associated bone disease persists even after complete remission.
Atkinson, Emily G.+7 more
core +1 more source
Finite Element Analysis of Bone Resorption Around Dental Implant
Previously, a few models have been proposed to predict bone resorption process due to stress shielding in long bones such as proximal femur; however, there are almost no reports on finite element analysis of loss of marginal dental bone that is caused ...
Lihe QIAN+3 more
doaj +1 more source