BMC Musculoskeletal Disorders, 2002 Background Avascular necrosis of bone (osteonecrosis) can cause structural failure and subsequent deformation, leading to joint dysfunction and pain. Structural failure is the result of resorption of necrotic bone during revascularization, before new ...
Aspenberg Per, Åstrand Jörgen
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Sympathetic Innervation Regulates Osteocyte‐Mediated Cortical Bone Resorption during Lactation
Advanced Science, 2023 Bone undergoes constant remodeling by osteoclast bone resorption coupled with osteoblast bone formation at the bone surface. A third major cell type in the bone is osteocytes, which are embedded in the matrix, are well‐connected to the lacunar network ...
Qiaoyue Guo +9 more
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The Bone Resorption Inhibitors Odanacatib and Alendronate Affect Post-Osteoclastic Events Differently in Ovariectomized Rabbits [PDF]
, 2013 Odanacatib (ODN) is a bone resorption inhibitor which differs from standard antiresorptives by its ability to reduce bone resorption without decreasing bone formation. What is the reason for this difference?
Andersen, Thomas Levin +4 more
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Governing equations of tissue modelling and remodelling: A unified generalised description of surface and bulk balance [PDF]
, 2016 Several biological tissues undergo changes in their geometry and in their bulk material properties by modelling and remodelling processes. Modelling synthesises tissue in some regions and removes tissue in others.
Buenzli, Pascal R.
core +8 more sources
A theory for bone resorption based on the local rupture of osteocytes cells connections: A finite element study [PDF]
, 2015 In this work, a bone damage resorption finite element model based on the disruption of the inhibitory signal transmitted between osteocytes cells in bone due to damage accumulation is developed and discussed. A strain-based stimulus function coupled to a
Abdessalem Chamekh +4 more
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Factors associated with implant marginal bone resorption after implant restoration in elderly patients with severe periodontitis [PDF]
Xin yixueObjective To analyze the factors related to implant marginal bone resorption after implant restoration in elderly patients with severe periodontitis. Methods One hundred and ninety-five elderly patients with severe periodontitis who underwent implant ...
LI Yue, MA Yanru
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Macrophages and Bone Remodeling
Journal of Bone and Mineral Research, 2023 Bone remodeling in the adult skeleton facilitates the removal and replacement of damaged and old bone to maintain bone quality. Tight coordination of bone resorption and bone formation during remodeling crucially maintains skeletal mass.
Megan M. Weivoda, E. Bradley
semanticscholar +1 more source
Vav1 inhibits RANKL-induced osteoclast differentiation and bone resorption [PDF]
, 2019 Vav1 is a Rho/Rac guanine nucleotide exchange factor primarily expressed in hematopoietic cells. In this study, we investigated the potential role of Vav1 in osteoclast (OC) differentiation by comparing the ability of bone marrow mononuclear cells (BMMCs)
Cha, Young-Nam +6 more
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International Journal of Molecular Sciences, 2022 Osteoporosis is a serious health issue among aging postmenopausal women. The majority of postmenopausal women with osteoporosis have bone loss related to estrogen deficiency. The rapid bone loss results from an increase in bone turnover with an imbalance
Chui H Cheng, Li-Ru Chen, Kuo-Hu Chen
semanticscholar +1 more source
Dual targeting of salt inducible kinases and CSF1R uncouples bone formation and bone resorption
eLife, 2021 Bone formation and resorption are typically coupled, such that the efficacy of anabolic osteoporosis treatments may be limited by bone destruction. The multi-kinase inhibitor YKL-05–099 potently inhibits salt inducible kinases (SIKs) and may represent a ...
Cheng-Chia Tang +25 more
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