Chronic administration of Glucagon-like peptide-1 receptor agonists improves trabecular bone mass and architecture in ovariectomised mice [PDF]
, 2015 Some anti-diabetic therapies can have adverse effects on bone health and increase fracture risk. In this study, we tested the skeletal effects of chronic administration of two Glucagon-like peptide-1 receptor agonists (GLP-1RA), increasingly used for ...
Al-Jazzar, A +9 more
core +2 more sources
Methods for evaluation of early bone healing at titanium implants [PDF]
, 2007 Titanium has for a long time been the implant material of choice when in need for abilities as strength, biocompatibility and stability. Although numbers of studies have been made, little is known about the early events in implant healing.
Hederstierna, Karin
core +1 more source
BMC Musculoskeletal Disorders, 2002 Background Avascular necrosis of bone (osteonecrosis) can cause structural failure and subsequent deformation, leading to joint dysfunction and pain. Structural failure is the result of resorption of necrotic bone during revascularization, before new ...
Aspenberg Per, Åstrand Jörgen
doaj +1 more source
Modelling the anabolic response of bone using a cell population model [PDF]
J Theor Biol 307 (2012) 42-52, 2011 To maintain bone mass during bone remodelling, coupling is required between bone resorption and bone formation. This coordination is achieved by a network of autocrine and paracrine signalling molecules between cells of the osteoclast lineage and cells of the osteoblastic lineage.
arxiv +1 more source
ELMO1 Regulates RANKL-Stimulated Differentiation and Bone Resorption of Osteoclasts
Frontiers in Cell and Developmental Biology, 2021 Bone homeostasis is a metabolic balance between the new bone formation by osteoblasts and old bone resorption by osteoclasts. Excessive osteoclastic bone resorption results in low bone mass, which is the major cause of bone diseases such as rheumatoid ...
Xinyue Liang +7 more
doaj +1 more source
Bone matrix components activate the NLRP3 inflammasome and promote osteoclast differentiation [PDF]
, 2017 The NLRP3 inflammasome senses a variety of signals referred to as danger associated molecular patterns (DAMPs), including those triggered by crystalline particulates or degradation products of extracellular matrix. Since some DAMPs confer tissue-specific
Abu-Amer, Yousef +9 more
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The fungal metabolite (+)-terrein abrogates osteoclast differentiation via suppression of the RANKL signaling pathway through NFATc1 [PDF]
, 2020 Pathophysiological bone resorption is commonly associated with periodontal disease and involves the excessive resorption of bone matrix by activated osteoclasts.
Hirai, Kimito +15 more
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Resorption controls bone anabolism driven by PTH receptor signaling in osteocytes [PDF]
, 2013 The contribution of remodeling-based bone formation coupled to osteoclast activity versus modeling-based bone formation that occurs independently of resorption, to the anabolic effect of PTH remains unclear.
Allen, Matthew R. +7 more
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Factors associated with implant marginal bone resorption after implant restoration in elderly patients with severe periodontitis [PDF]
Xin yixueObjective To analyze the factors related to implant marginal bone resorption after implant restoration in elderly patients with severe periodontitis. Methods One hundred and ninety-five elderly patients with severe periodontitis who underwent implant ...
LI Yue, MA Yanru
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Aplidin (plitidepsin) is a novel anti-myeloma agent with potent anti-resorptive activity mediated by direct effects on osteoclasts [PDF]
, 2019 Despite recent progress in its treatment, Multiple Myeloma (MM) remains incurable and its associated bone disease persists even after complete remission.
Atkinson, Emily G. +7 more
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