Results 31 to 40 of about 1,831,965 (356)

Dual targeting of salt inducible kinases and CSF1R uncouples bone formation and bone resorption

eLife, 2021
Bone formation and resorption are typically coupled, such that the efficacy of anabolic osteoporosis treatments may be limited by bone destruction. The multi-kinase inhibitor YKL-05–099 potently inhibits salt inducible kinases (SIKs) and may represent a ...
Cheng-Chia Tang, Christian D Castro Andrade, Maureen J O'Meara, Sung-Hee Yoon, Tadatoshi Sato, Daniel J Brooks, Mary L Bouxsein, Janaina da Silva Martins, Jinhua Wang, Nathanael S Gray, Barbara Misof, Paul Roschger, Stephane Blouin, Klaus Klaushofer, Annegreet Velduis-Vlug, Yosta Vegting, Clifford J Rosen, Daniel O'Connell, Thomas B Sundberg, Ramnik J Xavier, Peter Ung, Avner Schlessinger, Henry M Kronenberg, Rebecca Berdeaux, Marc Foretz, Marc N Wein   +25 more
doaj   +1 more source

Sympathetic Innervation Regulates Osteocyte‐Mediated Cortical Bone Resorption during Lactation

Advanced Science, 2023
Bone undergoes constant remodeling by osteoclast bone resorption coupled with osteoblast bone formation at the bone surface. A third major cell type in the bone is osteocytes, which are embedded in the matrix, are well‐connected to the lacunar network ...
Qiaoyue Guo, Ningrong Chen, Cheng Qian, Cheng Qi, Kathleen Noller, Mei Wan, Xiaonan Liu, Weixin Zhang, Patrick Cahan, Xu Cao   +9 more
doaj   +1 more source

Chronic administration of Glucagon-like peptide-1 receptor agonists improves trabecular bone mass and architecture in ovariectomised mice [PDF]

, 2015
Some anti-diabetic therapies can have adverse effects on bone health and increase fracture risk. In this study, we tested the skeletal effects of chronic administration of two Glucagon-like peptide-1 receptor agonists (GLP-1RA), increasingly used for ...
Al-Jazzar, A, Chavassieux, P, Chenu, C, Cleasby, M E, Hopkinson, M, Jeyabalan, J, Jorgensen, C S, Orriss, I R, Pereira, M, Roux, J P   +9 more
core   +2 more sources

Bone Resorption Is Regulated by Circadian Clock in Osteoblasts

Journal of Bone and Mineral Research, 2017
We have previously shown that endochondral ossification is finely regulated by the Clock system expressed in chondrocytes during postnatal skeletogenesis.
T. Takarada, Cheng Xu, H. Ochi, Ryota Nakazato, D. Yamada, Saki Nakamura, Ayumi Kodama, S. Shimba, Michihiro Mieda, Kazuya Fukasawa, Kakeru Ozaki, Takashi Iezaki, Koichi Fujikawa, Y. Yoneda, R. Numano, A. Hida, H. Tei, S. Takeda, E. Hinoi   +18 more
semanticscholar   +1 more source

Coupling of Bone Resorption and Formation in Real Time: New Knowledge Gained From Human Haversian BMUs

Journal of Bone and Mineral Research, 2017
It is well known that bone remodeling starts with a resorption event and ends with bone formation. However, what happens in between and how resorption and formation are coupled remains mostly unknown.
Nicolai Ernlund Lassen, T. L. Andersen, G. Pløen, K. Søe, E. Hauge, S. Harving, G. Eschen, J. Delaissé   +7 more
semanticscholar   +1 more source

Mechanical regulation of bone remodeling

Bone Research, 2022
Bone remodeling is a lifelong process that gives rise to a mature, dynamic bone structure via a balance between bone formation by osteoblasts and resorption by osteoclasts.
Lijun Wang, Xiuling You, Lingli Zhang, Changqing Zhang, Weiguo Zou   +4 more
semanticscholar   +1 more source

Systemic alendronate prevents resorption of necrotic bone during revascularization. A bone chamber study in rats

BMC Musculoskeletal Disorders, 2002
Background Avascular necrosis of bone (osteonecrosis) can cause structural failure and subsequent deformation, leading to joint dysfunction and pain. Structural failure is the result of resorption of necrotic bone during revascularization, before new ...
Aspenberg Per, Åstrand Jörgen
doaj   +1 more source

Modelling the anabolic response of bone using a cell population model [PDF]

J Theor Biol 307 (2012) 42-52, 2011
To maintain bone mass during bone remodelling, coupling is required between bone resorption and bone formation. This coordination is achieved by a network of autocrine and paracrine signalling molecules between cells of the osteoclast lineage and cells of the osteoblastic lineage.
arxiv   +1 more source

Methods for evaluation of early bone healing at titanium implants [PDF]

, 2007
Titanium has for a long time been the implant material of choice when in need for abilities as strength, biocompatibility and stability. Although numbers of studies have been made, little is known about the early events in implant healing.
Hederstierna, Karin
core   +1 more source

Mechanisms of Bone Resorption in Periodontitis

Journal of Immunological Research, 2015
Alveolar bone loss is a hallmark of periodontitis progression and its prevention is a key clinical challenge in periodontal disease treatment. Bone destruction is mediated by the host immune and inflammatory response to the microbial challenge.
S. Hienz, Sweta Paliwal, S. Ivanovski
semanticscholar   +1 more source