Results 41 to 50 of about 1,831,965 (356)

Bone matrix components activate the NLRP3 inflammasome and promote osteoclast differentiation [PDF]

, 2017
The NLRP3 inflammasome senses a variety of signals referred to as danger associated molecular patterns (DAMPs), including those triggered by crystalline particulates or degradation products of extracellular matrix. Since some DAMPs confer tissue-specific
Abu-Amer, Yousef, Alippe, Yael, Civitelli, Roberto, Mbalaviele, Gabriel, Novack, Deborah V, Qu, Chao, Ricci, Biancamaria, Wang, Chun, Xiao, Jianqiu, Zou, Wei   +9 more
core   +2 more sources

ELMO1 Regulates RANKL-Stimulated Differentiation and Bone Resorption of Osteoclasts

Frontiers in Cell and Developmental Biology, 2021
Bone homeostasis is a metabolic balance between the new bone formation by osteoblasts and old bone resorption by osteoclasts. Excessive osteoclastic bone resorption results in low bone mass, which is the major cause of bone diseases such as rheumatoid ...
Xinyue Liang, Yafei Hou, Lijuan Han, Shuxiang Yu, Yunyun Zhang, Xiumei Cao, Jianshe Yan, Jianshe Yan   +7 more
doaj   +1 more source

Circadian Clock Regulates Bone Resorption in Mice

Journal of Bone and Mineral Research, 2016
The circadian clock controls many behavioral and physiological processes beyond daily rhythms. Circadian dysfunction increases the risk of cancer, obesity, and cardiovascular and metabolic diseases.
Cheng Xu, H. Ochi, T. Fukuda, Shingo Sato, Satoko Sunamura, T. Takarada, E. Hinoi, A. Okawa, S. Takeda   +8 more
semanticscholar   +1 more source

Factors associated with implant marginal bone resorption after implant restoration in elderly patients with severe periodontitis [PDF]

Xin yixue
Objective To analyze the factors related to implant marginal bone resorption after implant restoration in elderly patients with severe periodontitis. Methods One hundred and ninety-five elderly patients with severe periodontitis who underwent implant ...
LI Yue, MA Yanru
doaj   +1 more source

Resorption controls bone anabolism driven by PTH receptor signaling in osteocytes [PDF]

, 2013
The contribution of remodeling-based bone formation coupled to osteoclast activity versus modeling-based bone formation that occurs independently of resorption, to the anabolic effect of PTH remains unclear.
Allen, Matthew R., Bellido, Teresita, Condon, Keith W., Lee, Eun-Young, Lezcano, Virginia, Plotkin, Lilian I., Rhee, Yumie, Ronda, Ana C.   +7 more
core   +1 more source

Osteoclast TGF‐β Receptor Signaling Induces Wnt1 Secretion and Couples Bone Resorption to Bone Formation

Journal of Bone and Mineral Research, 2016
Osteoblast‐mediated bone formation is coupled to osteoclast‐mediated bone resorption. These processes become uncoupled with age, leading to increased risk for debilitating fractures.
Megan M. Weivoda, M. Ruan, Larry Pederson, Christine M. Hachfeld, R. Davey, J. Zajac, J. Westendorf, S. Khosla, M. Oursler   +8 more
semanticscholar   +1 more source

Osteocyte Apoptosis Caused by Hindlimb Unloading is Required to Trigger Osteocyte RANKL Production and Subsequent Resorption of Cortical and Trabecular Bone in Mice Femurs

Journal of Bone and Mineral Research, 2016
Osteocyte apoptosis is essential to activate bone remodeling in response to fatigue microdamage and estrogen withdrawal, such that apoptosis inhibition in vivo prevents the onset of osteoclastic resorption.
Pamela Cabahug-Zuckerman, Dorra Frikha‐Benayed, R. Majeska, Alyssa Tuthill, S. Yakar, S. Judex, M. Schaffler   +6 more
semanticscholar   +1 more source

Aplidin (plitidepsin) is a novel anti-myeloma agent with potent anti-resorptive activity mediated by direct effects on osteoclasts [PDF]

, 2019
Despite recent progress in its treatment, Multiple Myeloma (MM) remains incurable and its associated bone disease persists even after complete remission.
Atkinson, Emily G., Bellido, Teresita, Delgado-Calle, Jesus, Galmarini, Carlos Maria, Kurihara, Noriyoshi, Miyagawa, Kazuaki, Nelson, Jessica, Roodman, G. David   +7 more
core   +1 more source

Hypoxic regulation of osteoclast differentiation and bone resorption activity

Hypoxia, 2015
Bone integrity is maintained throughout life via the homeostatic actions of bone cells, namely, osteoclasts, which resorb bone, and osteoblasts, which produce bone. Disruption of this balance in favor of osteoclast activation results in pathological bone
H. Knowles
semanticscholar   +1 more source

Repair of microdamage in osteonal cortical bone adjacent to bone screw.

PLoS ONE, 2014
Up to date, little is known about the repair mode of microdamage in osteonal cortical bone resulting from bone screw implantation. In this study, self-tapping titanium cortical bone screws were inserted into the tibial diaphyses of 24 adult male rabbits.
Lei Wang, Tingjun Ye, Lianfu Deng, Jin Shao, Jin Qi, Qi Zhou, Li Wei, Shijing Qiu   +7 more
doaj   +1 more source