Results 41 to 50 of about 1,917,572 (398)
A theory for bone resorption based on the local rupture of osteocytes cells connections: A finite element study [PDF]
, 2015 In this work, a bone damage resorption finite element model based on the disruption of the inhibitory signal transmitted between osteocytes cells in bone due to damage accumulation is developed and discussed. A strain-based stimulus function coupled to a
Abdessalem Chamekh +4 more
core +1 more source
Cellular and molecular mediators of bone metastatic lesions [PDF]
, 2018 Bone is the preferential site of metastasis for breast and prostate tumor. Cancer cells establish a tight relationship with the host tissue, secreting factors that stimulate or inhibit bone cells, receiving signals generated from the bone remodeling ...
Battafarano, Giulia +3 more
core +5 more sources
Dual targeting of salt inducible kinases and CSF1R uncouples bone formation and bone resorption
eLife, 2021 Bone formation and resorption are typically coupled, such that the efficacy of anabolic osteoporosis treatments may be limited by bone destruction. The multi-kinase inhibitor YKL-05–099 potently inhibits salt inducible kinases (SIKs) and may represent a ...
Cheng-Chia Tang +25 more
doaj +1 more source
OSTEOBLASTS MEDIATE INTERLEUKIN-1 STIMULATION OF BONE-RESORPTION BY RAT OSTEOCLASTS [PDF]
, 1986 A monocyte-derived factor with IL-1-like properties has recently been shown to cause resorption of bone in organ culture. We have investigated the action of IL-1 on disaggregated populations of osteoclasts, incubated alone or in the presence of ...
Chambers, TJ, Saklatvala, J, Thomson, BM
core +2 more sources
Repair of microdamage in osteonal cortical bone adjacent to bone screw.
PLoS ONE, 2014 Up to date, little is known about the repair mode of microdamage in osteonal cortical bone resulting from bone screw implantation. In this study, self-tapping titanium cortical bone screws were inserted into the tibial diaphyses of 24 adult male rabbits.
Lei Wang +7 more
doaj +1 more source
ELMO1 Regulates RANKL-Stimulated Differentiation and Bone Resorption of Osteoclasts
Frontiers in Cell and Developmental Biology, 2021 Bone homeostasis is a metabolic balance between the new bone formation by osteoblasts and old bone resorption by osteoclasts. Excessive osteoclastic bone resorption results in low bone mass, which is the major cause of bone diseases such as rheumatoid ...
Xinyue Liang +7 more
doaj +1 more source
Journal of Pharmacological Sciences, 2011 Nobiletin, a polymethoxy flavonoid, prevents cancer and inflammation, but the roles of nobiletin in bone are unclear. We examined the effects of nobiletin on bone resorption in vitro and on bone mass in ovariectomized (OVX) mice in vivo.
Suguru Harada +6 more
doaj +1 more source
Hypoxic regulation of osteoclast differentiation and bone resorption activity
Hypoxia, 2015 Bone integrity is maintained throughout life via the homeostatic actions of bone cells, namely, osteoclasts, which resorb bone, and osteoblasts, which produce bone. Disruption of this balance in favor of osteoclast activation results in pathological bone
H. Knowles
semanticscholar +1 more source
Drugs, 2015 Bone remodeling, the fundamental process for bone renewal, is targeted by treatments of osteoporosis to correct the imbalance between bone resorption and bone formation and reduce the risk of fractures and associated clinical consequences.
N. Appelman‐Dijkstra, S. Papapoulos
semanticscholar +1 more source
BiomedicinesAims: This study was conducted to systematically evaluate the biomechanical impact of varying degrees of root and bone resorption resulting from periodontitis and orthodontic tooth movement (OTM) on the mandibular anterior teeth.
Jana Flatten +4 more
doaj +1 more source