Results 51 to 60 of about 1,917,572 (398)
P38 mitogen-activated protein kinase inhibitor, FR167653, inhibits parathyroid hormone related protein-induced osteoclastogenesis and bone resorption. [PDF]
PLoS ONE, 2011 p38 mitogen-activated protein kinase (MAPK) acts downstream in the signaling pathway that includes receptor activator of NF-κB (RANK), a powerful inducer of osteoclast formation and activation.
Huiren Tao +4 more
doaj +1 more source
Focus ion beam/scanning electron microscopy characterization of osteoclastic resorption of calcium phosphate substrates [PDF]
, 2017 This article presents the application of dual focused ion beam/scanning electron microscopy (FIB-SEM) imaging for preclinical testing of calcium phosphates with osteoclast precursor cells and how this high-resolution imaging technique is able to reveal ...
Baldini, Nicola +6 more
core +2 more sources
Journal of Pharmacological Sciences, 2008 The vertebrate skeleton is richly innervated with adrenergic and peptidergic nerve terminals, and these play important roles in bone remodeling. Recent studies have generally shown that increased sympathetic nervous activity causes bone loss via an ...
Akifumi Togari, Michitsugu Arai
doaj +1 more source
Osteoclast biology in bone resorption: a review
STEMedicine, 2020 What we know about bone resorption has changed a lot in the last few decades. The osteoclast is the only cell to nibble and break down the bone, and in the formation and resorption of bone tissue, osteoclasts play an important role.
Chao Fu, Ruyi Shi
doaj +1 more source
Podosome organization drives osteoclast-mediated bone resorption
Cell Adhesion & Migration, 2014 Osteoclasts are the cells responsible for physiological bone resorption. A specific organization of their most prominent cytoskeletal structures, podosomes, is crucial for the degradation of mineralized bone matrix.
D. Georgess +3 more
semanticscholar +1 more source
CELLULAR BIOLOGY OF BONE RESORPTION
Biological Reviews, 1993 SummaryPast knowledge and the recent developments on the formation, activation and mode of action of osteoclasts, with particular reference to the regulation of each individual step, have been reviewed. The following conclusions of consensus have emerged.1.
Mone Zaidi +10 more
openaire +4 more sources
Advanced Engineering Materials, EarlyView.This study reports the fabrication of trabecular bioactive glass scaffolds (composition “1d”: 46.1SiO2‐28.7CaO‐8.8MgO‐6.2P2O5‐5.7CaF2‐4.5Na2O wt%) through vat photopolymerization and the relevant results from mechanical testing and in vivo implantation procedures in rabbit femora, showing great promise for bone tissue engineering applications.
Dilshat Tulyaganov +8 more
wiley +1 more source
Transient Local Bone Remodeling Effects of rhBMP-2 in an Ovine Interbody Spine Fusion Model [PDF]
, 2016 Background: Recombinant human bone morphogenetic protein-2 (rhBMP-2) is a powerful osteoinductive morphogen capable of stimulating the migration of mesenchymal stem cells (MSCs) to the site of implantation and inducing the proliferation and ...
Badura, Jeffrey +7 more
core +1 more source
Toddaculin, Isolated from of Toddalia asiatica (L.) Lam., Inhibited Osteoclastogenesis in RAW 264 Cells and Enhanced Osteoblastogenesis in MC3T3-E1 Cells. [PDF]
PLoS ONE, 2015 Osteoporosis with bone loss is widely recognized as a major health problem. Bone homeostasis is maintained by balancing bone formation and bone resorption.
Akio Watanabe +13 more
doaj +1 more source
BioMed Research International, 2014 Periodontitis and other bone loss diseases, decreasing bone volume and strength, have a significant impact on millions of people with the risk of tooth loss and bone fracture.
Qian Zhang +6 more
semanticscholar +1 more source