Drugs, 2015 Bone remodeling, the fundamental process for bone renewal, is targeted by treatments of osteoporosis to correct the imbalance between bone resorption and bone formation and reduce the risk of fractures and associated clinical consequences.
N. Appelman‐Dijkstra, S. Papapoulos
semanticscholar +1 more source
BiomedicinesAims: This study was conducted to systematically evaluate the biomechanical impact of varying degrees of root and bone resorption resulting from periodontitis and orthodontic tooth movement (OTM) on the mandibular anterior teeth.
Jana Flatten +4 more
doaj +1 more source
Governing equations of tissue modelling and remodelling: A unified generalised description of surface and bulk balance [PDF]
Buenzli PR (2016) PLoS ONE 11(4):e0152582, 2015 Several biological tissues undergo changes in their geometry and in their bulk material properties by modelling and remodelling processes. Modelling synthesises tissue in some regions and removes tissue in others. Remodelling overwrites old tissue material properties with newly formed, immature tissue properties.
arxiv +1 more source
Negative regulation of osteoclastogenesis and bone resorption by cytokines and transcriptional repressors [PDF]
, 2011 Bone remodeling in physiological and pathological conditions represents a balance between bone resorption mediated by osteoclasts and bone formation by osteoblasts.
Ivashkiv, Lionel B, Zhao, Baohong
core +2 more sources
Aging Leads to a Dysregulation in Mechanically Driven Bone Formation and Resorption
Journal of Bone and Mineral Research, 2015 Physical activity is essential to maintain skeletal mass and structure, but its effect seems to diminish with age. To test the hypothesis that bone becomes less sensitive to mechanical strain with age, we used a combined in vivo/in silico approach.
H. Razi +5 more
semanticscholar +1 more source
The Bone Resorption Inhibitors Odanacatib and Alendronate Affect Post-Osteoclastic Events Differently in Ovariectomized Rabbits [PDF]
, 2013 Odanacatib (ODN) is a bone resorption inhibitor which differs from standard antiresorptives by its ability to reduce bone resorption without decreasing bone formation. What is the reason for this difference?
Andersen, Thomas Levin +4 more
core +1 more source
Podosome organization drives osteoclast-mediated bone resorption
Cell Adhesion & Migration, 2014 Osteoclasts are the cells responsible for physiological bone resorption. A specific organization of their most prominent cytoskeletal structures, podosomes, is crucial for the degradation of mineralized bone matrix.
D. Georgess +3 more
semanticscholar +1 more source
BioMed Research International, 2014 Periodontitis and other bone loss diseases, decreasing bone volume and strength, have a significant impact on millions of people with the risk of tooth loss and bone fracture.
Qian Zhang +6 more
semanticscholar +1 more source
The influence of bone surface availability in bone remodelling - A mathematical model including coupled geometrical and biomechanical regulations of bone cells [PDF]
Eng Struct (2013) 47:134-147, 2012 Bone is a biomaterial undergoing continuous renewal. The renewal process is known as bone remodelling and is operated by bone-resorbing cells (osteoclasts) and bone-forming cells (osteoblasts). Both biochemical and biomechanical regulatory mechanisms have been identified in the interaction between osteoclasts and osteoblasts.
arxiv +1 more source
Transient Local Bone Remodeling Effects of rhBMP-2 in an Ovine Interbody Spine Fusion Model [PDF]
, 2016 Background: Recombinant human bone morphogenetic protein-2 (rhBMP-2) is a powerful osteoinductive morphogen capable of stimulating the migration of mesenchymal stem cells (MSCs) to the site of implantation and inducing the proliferation and ...
Badura, Jeffrey +7 more
core +1 more source