Results 211 to 220 of about 177,216 (256)
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Minimally Invasive Therapy & Allied Technologies, 2002
Despite well-established bone-grafting techniques, large bone defects still represent a challenge for orthopaedic and reconstructive surgeons. Efforts have therefore been made to develop osteoconductive, osteoinductive and osteogenic bone-replacement systems.
Kneser, Ulrich +5 more
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Despite well-established bone-grafting techniques, large bone defects still represent a challenge for orthopaedic and reconstructive surgeons. Efforts have therefore been made to develop osteoconductive, osteoinductive and osteogenic bone-replacement systems.
Kneser, Ulrich +5 more
openaire +3 more sources
Tissue-engineered bone regeneration
Nature Biotechnology, 2000Bone lesions above a critical size become scarred rather than regenerated, leading to nonunion. We have attempted to obtain a greater degree of regeneration by using a resorbable scaffold with regeneration-competent cells to recreate an embryonic environment in injured adult tissues, and thus improve clinical outcome.
H, Petite +8 more
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Electrospinning for Bone Tissue Engineering
Recent Patents on Nanotechnology, 2008Bone tissue engineering is a field of significant research interest owing to the large number of bone defects and the limitations in the present techniques to effectively reconstitute the defects. Cell-based bone graft technique has shown promise in overcoming the limitations of the other bone graft techniques currently used.
Koushik, Ramachandran +1 more
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Peptides for bone tissue engineering
Journal of Controlled Release, 2016Molecular signals in the form of growth factors are the main modulators of cell behavior. However, the use of growth factors in tissue engineering has several drawbacks, including their costs, difficult production, immunogenicity and short half-life. Furthermore, many of them are pleiotropic and, since a single growth factor can have different active ...
Rick, Visser +3 more
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Perspectives on Tissue Engineering of Bone
Clinical Orthopaedics and Related Research, 1999The normal repair and regeneration of bone occurs through an ordered and regulated sequence of cellular events. Successful replacement of bone through tissue engineering likely will be dependent on the recapitulation of this cascade of events. This report presents some of the principles to be considered in the design of engineered bone constructs.
S A, Goldstein, P V, Patil, M R, Moalli
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An Overview of Tissue Engineered Bone
Clinical Orthopaedics and Related Research, 1999Numerous important developments in tissue engineering of new bone during the last 10 years are reviewed. Early efforts to combine cells with biocompatible materials are described and applications of this technology are presented with particular focus on uses in orthopaedics and maxillofacial surgery.
C A, Vacanti, L J, Bonassar
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Bone Marrow Tissue Engineering
Tissue Engineering, 2002The creation of mixed hematopoietic chimerism has become an important clinical strategy for tolerance induction for cellular and organ transplantation, and for the treatment of numerous hematopoietic diseases. Clinical success has been limited however, by host immune response and by competition from host hematopoiesis. Recent data suggests that limited
Alexander S, Krupnick +3 more
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Osteoblasts in bone tissue engineering
Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine, 2010Osteoblasts are integral to the development, growth, function, repair and maintenance of bone. The osteoblast forms organic, non-mineralized bone matrix and is involved in complex interactions with a variety of factors, mediators and cell types. Degeneration, pathology, and trauma cause disruption and destruction of the normal skeletal environment and ...
Jayakumar, P., Di Silvio, L.
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Craniofacial Bone Tissue Engineering
Dental Clinics of North America, 2006Repair and reconstruction of the craniofacial skeleton represents a significant biomedical burden, with thousands of procedures per-formed annually secondary to injuries and congenital malformations. Given the multitude of current approaches, the need for more effective strategies to repair these bone deficits is apparent.
Derrick C, Wan +2 more
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Bioreactors for Bone Tissue Engineering
The International Journal of Artificial Organs, 2011Bone tissue engineering is a promising solution for patients with bone defects that require reconstruction. This regenerative therapy consists in culturing osteogenic cells on a biodegradable substrate to obtain a bio-hybrid construct that will stimulate bone healing after implantation.
Benoît, Carpentier +2 more
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